Detalhe da pesquisa
1.
Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug.
Exp Parasitol
; 260: 108744, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38513971
2.
Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue.
Bioorg Med Chem
; 92: 117424, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37517101
3.
Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors.
Mol Pharmacol
; 101(1): 33-44, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34718224
4.
Junctions in DNA: underexplored targets for therapeutic intervention.
Bioorg Med Chem
; 69: 116897, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35764032
5.
Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds.
Bioorg Med Chem
; 40: 116167, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932713
6.
Active targeting of gold nanoparticles as cancer therapeutics.
Chem Soc Rev
; 49(23): 8774-8789, 2020 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33089858
7.
A Peptide-Duocarmycin Conjugate Targeting the Thomsen-Friedenreich Antigen Has Potent and Selective Antitumor Activity.
Bioconjug Chem
; 31(7): 1745-1749, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32515945
8.
Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction.
Bioorg Med Chem Lett
; 28(16): 2728-2731, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534931
9.
Cytotoxicity of Pyrazine-Based Cyclometalated (C
Inorg Chem
; 56(10): 5728-5740, 2017 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28441013
10.
Unveiling the "Three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach.
Chemistry
; 22(17): 5858-62, 2016 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26864212
11.
Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity.
J Org Chem
; 80(19): 9454-67, 2015 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26356089
12.
Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin.
Bioorg Med Chem Lett
; 25(21): 4878-4880, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26115576
13.
Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).
Biochem Biophys Res Commun
; 447(1): 128-32, 2014 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24699415
14.
Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy.
Org Biomol Chem
; 11(48): 8340-7, 2013 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24158749
15.
The development of potent, competitive CXCR4 antagonists for the prevention of cancer metastasis.
Biochem Pharmacol
; 218: 115921, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37956893
16.
Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition.
Br J Pharmacol
; 178(24): 4859-4872, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34398973
17.
Design and synthesis of threading intercalators to target DNA.
Bioorg Med Chem Lett
; 20(23): 6956-9, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20980148
18.
Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers.
RSC Med Chem
; 12(2): 288-292, 2020 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34041483
19.
Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.
J Am Chem Soc
; 131(15): 5564-72, 2009 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19334711
20.
Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry.
Bioorg Med Chem Lett
; 19(20): 5880-3, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19740660