Erythrocytic membrane anionic charge, sialic acid content, and their correlations with urinary glycosaminoglycans in preeclampsia and eclampsia.

Compared to healthy pregnant women, changes in erythrocytic membrane anionic charge (EAC) and urinary glycosaminoglycans (UGAGS) have been reported in African women with preeclampsia. A single previous study showed a decrease in erythrocytic membrane sialic acid (EMSA) in preeclampsia compared to healthy pregnancy; however, EMSA was not significantly different between women with preeclampsia and non-pregnant women. No study has focused on the relationships between EAC, EMSA, and UGAGS in preeclampsia and eclampsia compared to healthy pregnant and non-pregnant women of reproductive age. Moreover, the erythrocyte membrane contains sialoglycoproteins and proteoglycans involved in creating the negatively charged cell surface, disruption of which leads to erythrocyte aggregation seen in preeclampsia/eclampsia. However, the etiopathogenesis of preeclampsia and eclampsia remains unclear. Therefore, we evaluated the relationship between EAC, UGAGS, and EMSA in preeclampsia and eclampsia. Three groups of 30 women each were enrolled: Group A (non-pregnant women), Group B (healthy pregnant women without complications), and Group C (women with preeclampsia/eclampsia). EMSA was diminished under oxidative stress prevalent in eclampsia and preeclampsia which might have caused a decreased EAC. EAC was negatively correlated with UGAGS and positively correlated with EMSA (p < .001). EMSA was negatively correlated with UGAGS (p < .001). In conclusion, a loss of sialic acid from the erythrocyte membrane causes a significant decrease in the EAC which mirrors the decrease in the negative charge of the renal glomerular basement membrane and might lead to proteinuria and increased UGAGS excretion in preeclampsia and eclampsia.

Rapid spontaneous cerebrospinal fluid leak detected in the gastrointestinal tract.

There are many causes of cerebrospinal (CSF) leaks. Most cases are secondary to blunt trauma and iatrogenic trauma caused by postoperative sequelae. Occasionally, CSF leakage may occur from nontraumatic or "spontaneous" causes, such as benign intracranial hypertension and "empty sella syndrome." Mass effect due to an encephalocele or meningocele may also be seen. Radionuclide cisternography is a sensitive method of determining CSF leak when combined with intranasal cotton pledget placement and analysis. We present a spontaneous CSF fluid leak that was detected when scintigraphic activity appeared first in the gastrointestinal tract.