Detalhe da pesquisa
1.
Expression of transduced nucleolin promotes the clearance of accumulated α-synuclein in rodent cells and animal model.
Neurobiol Dis
; 154: 105349, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33781924
2.
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.
Hum Mol Genet
; 26(1): 1-18, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27798112
3.
LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death.
Biochim Biophys Acta Mol Cell Res
; 1864(12): 2356-2368, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28888991
4.
LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase.
Cell Biochem Funct
; 36(8): 431-442, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30411383
5.
Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor α-mediated neurotoxicity.
Biochem Biophys Res Commun
; 482(4): 1088-1094, 2017 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914807
6.
LRRK2 interferes with aggresome formation for autophagic clearance.
Mol Cell Neurosci
; 75: 71-80, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27364102
7.
Effects of mood-stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neurons.
Bipolar Disord
; 17(3): 278-90, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25307211
8.
Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons.
Int J Neuropsychopharmacol
; 17(11): 1831-46, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24901414
9.
Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease.
Acta Neuropathol Commun
; 12(1): 5, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38172953
10.
Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.
Lab Invest
; 93(6): 663-76, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23608757
11.
Effects of antipsychotic drugs on the expression of synaptic proteins and dendritic outgrowth in hippocampal neuronal cultures.
Synapse
; 67(5): 224-34, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23335099
12.
A novel HDAC6 inhibitor, CKD-504, is effective in treating preclinical models of huntington's disease.
BMB Rep
; 56(2): 178-183, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36593104
13.
LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss.
Cells
; 11(5)2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35269482
14.
Direct interaction of α-synuclein and AKT regulates IGF-1 signaling: implication of Parkinson disease.
Neurosignals
; 19(2): 86-96, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21474915
15.
Identification of chemicals to inhibit the kinase activity of leucine-rich repeat kinase 2 (LRRK2), a Parkinson's disease-associated protein.
Bioorg Med Chem Lett
; 21(10): 2953-7, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21474311
16.
LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.
Exp Cell Res
; 316(4): 649-56, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19769964
17.
LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells.
Oxid Med Cell Longev
; 2021: 9969842, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34306319
18.
Analysis of α-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson's disease.
Anim Cells Syst (Seoul)
; 25(1): 28-36, 2021 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33717414
19.
Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons.
Exp Neurobiol
; 30(3): 232-243, 2021 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34230223
20.
Astrocytes in injury states rapidly produce anti-inflammatory factors and attenuate microglial inflammatory responses.
J Neurochem
; 115(5): 1161-71, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21039520