Detalhe da pesquisa
1.
Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones.
Malar J
; 20(1): 107, 2021 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33608015
2.
Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
Bioorg Med Chem
; 37: 116116, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33799173
3.
An in vitro toolbox to accelerate anti-malarial drug discovery and development.
Malar J
; 19(1): 1, 2020 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31898492
4.
Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations.
Mol Pharm
; 15(12): 5678-5696, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30376336
5.
Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds.
Pharm Res
; 35(11): 210, 2018 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30225649
6.
SAR of a new antischistosomal urea carboxylic acid.
Bioorg Med Chem Lett
; 28(23-24): 3648-3651, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30389288
7.
Progress in antischistosomal N,N'-diaryl urea SAR.
Bioorg Med Chem Lett
; 28(3): 244-248, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29317164
8.
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
Bioorg Med Chem
; 26(11): 2996-3005, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779669
9.
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
Proc Natl Acad Sci U S A
; 111(50): E5455-62, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453091
10.
Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior.
J Pharmacol Exp Ther
; 359(2): 354-365, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27630144
11.
Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties.
Antimicrob Agents Chemother
; 59(6): 3645-7, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25845874
12.
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Antimicrob Agents Chemother
; 58(8): 4362-70, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841257
13.
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Proc Natl Acad Sci U S A
; 108(11): 4400-5, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300861
14.
3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy.
Bioorg Med Chem Lett
; 23(24): 6868-73, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24169234
15.
Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties.
Bioorg Med Chem Lett
; 23(2): 455-9, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23245512
16.
Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.
Bioorg Med Chem
; 21(7): 1756-63, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23462713
17.
Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus.
Pharmaceutics
; 15(7)2023 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37514160
18.
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Eur J Med Chem
; 258: 115588, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37423123
19.
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
Sci Transl Med
; 15(726): eadh9902, 2023 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091406
20.
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Antimicrob Agents Chemother
; 56(9): 4914-21, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22777048