Pesquisa | Portal de Pesquisa da BVS

1.

The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone.

Rao, V Ashutosh; Klein, Sarah R; Bonar, Spencer J; Zielonka, Jacek; Mizuno, Naoko; Dickey, Jennifer S; Keller, Paul W; Joseph, Joy; Kalyanaraman, Balaraman; Shacter, Emily.

J Biol Chem ; 285(45): 34447-59, 2010 Nov 05.

Artigo em Inglês | MEDLINE | ID: mdl-20805228

2.

Chronic inflammation and cancer: the role of the mitochondria.

Kamp, David W; Shacter, Emily; Weitzman, Sigmund A.

Oncology (Williston Park) ; 25(5): 400-10, 413, 2011 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-21710835

3.

The FDA's assessment of follow-on protein products: a historical perspective.

Woodcock, Janet; Griffin, Joseph; Behrman, Rachel; Cherney, Barry; Crescenzi, Terrie; Fraser, Blair; Hixon, Dena; Joneckis, Christopher; Kozlowski, Steven; Rosenberg, Amy; Schrager, Lewis; Shacter, Emily; Temple, Robert; Webber, Keith; Winkle, Helen.

Nat Rev Drug Discov ; 6(6): 437-42, 2007 06.

Artigo em Inglês | MEDLINE | ID: mdl-17633790

4.

PDA Biosimilars Workshop Report (September 27-28, 2018)-Getting It Right the First Time for Biosimilar Marketing Applications.

Krause, Stephan; Lacana, Emanuela; Welch, Joel; Shapiro, Marjorie; Downey, Christopher; Chung, Jee; Zhou, Qing; Van Der Plas, Martijn; Depatie, Chantal; Ingram, Bev; Srebalus-Barnes, Catherine; Polozova, Alla; Rellahan, Barbara; Choi, Daeseok; Burdick, Richard; Stangler, Thomas; Shacter, Emily.

PDA J Pharm Sci Technol ; 73(4): 401-416, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31004040

5.

Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75.

Zhang, Baolin; Zhang, Yaqin; Shacter, Emily.

Mol Cell Biol ; 24(14): 6205-14, 2004 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-15226424

6.

Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells.

Zhang, Baolin; Zhang, Yaqin; Shacter, Emily.

Mol Cell Biol ; 23(16): 5716-25, 2003 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-12897143

7.

Rho GDP dissociation inhibitor protects cancer cells against drug-induced apoptosis.

Zhang, Baolin; Zhang, Yaqin; Dagher, Marie-Claire; Shacter, Emily.

Cancer Res ; 65(14): 6054-62, 2005 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-16024605

8.

Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin.

Hoke, Eileen M; Maylock, Caroline A; Shacter, Emily.

Free Radic Biol Med ; 39(3): 403-11, 2005 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-15993339

9.

Natural anticoagulant proteins in the regulation of autoimmunity: potential role of protein S.

Anderson, Howard A; Shacter, Emily.

Curr Pharm Des ; 10(8): 929-37, 2004.

Artigo em Inglês | MEDLINE | ID: mdl-15032696

10.

Chronic inflammation and cancer.

Shacter, Emily; Weitzman, Sigmund A.

Oncology (Williston Park) ; 16(2): 217-26, 229; discussion 230-2, 2002 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-11866137

11.

Taurine chloramine-induced inactivation of cofilin protein through methionine oxidation.

Luo, Shen; Uehara, Hiroshi; Shacter, Emily.

Free Radic Biol Med ; 75: 84-94, 2014 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-25058340

12.

Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model.

Dickey, Jennifer S; Gonzalez, Yanira; Aryal, Baikuntha; Mog, Steven; Nakamura, Asako J; Redon, Christophe E; Baxa, Ulrich; Rosen, Elliot; Cheng, Gang; Zielonka, Jacek; Parekh, Palak; Mason, Karen P; Joseph, Joy; Kalyanaraman, Balaraman; Bonner, William; Herman, Eugene; Shacter, Emily; Rao, V Ashutosh.

PLoS One ; 8(8): e70575, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23940596

13.

The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats.

Rao, V Ashutosh; Zhang, Jun; Klein, Sarah R; Espandiari, Parvaneh; Knapton, Alan; Dickey, Jennifer S; Herman, Eugene; Shacter, Emily B.

Cancer Chemother Pharmacol ; 68(5): 1125-34, 2011 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-21373894

14.

CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer.

Castro, Mauro Antonio Alves; Dal-Pizzol, Felipe; Zdanov, Stephanie; Soares, Marcio; Müller, Carolina Beatriz; Lopes, Fernanda Martins; Zanotto-Filho, Alfeu; da Cruz Fernandes, Marilda; Moreira, Jose Claudio Fonseca; Shacter, Emily; Klamt, Fábio.

Cancer ; 116(15): 3645-55, 2010 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-20564088

15.

The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells.

Rao, V Ashutosh; Klein, Sarah R; Agama, Keli K; Toyoda, Eriko; Adachi, Noritaka; Pommier, Yves; Shacter, Emily B.

Cancer Res ; 69(3): 948-57, 2009 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-19176392

16.

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin.

Klamt, Fábio; Zdanov, Stéphanie; Levine, Rodney L; Pariser, Ashley; Zhang, Yaqin; Zhang, Baolin; Yu, Li-Rong; Veenstra, Timothy D; Shacter, Emily.

Nat Cell Biol ; 11(10): 1241-6, 2009 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-19734890

17.

Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells.

Uehara, Hiroshi; Shacter, Emily.

J Immunol ; 180(4): 2522-30, 2008 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-18250462

18.

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

Chen, Qi; Espey, Michael Graham; Sun, Andrew Y; Lee, Je-Hyuk; Krishna, Murali C; Shacter, Emily; Choyke, Peter L; Pooput, Chaya; Kirk, Kenneth L; Buettner, Garry R; Levine, Mark.

Proc Natl Acad Sci U S A ; 104(21): 8749-54, 2007 May 22.

Artigo em Inglês | MEDLINE | ID: mdl-17502596

19.

Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage.

Klamt, Fabio; Shacter, Emily.

J Biol Chem ; 280(22): 21346-52, 2005 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-15799967

20.

Importance of cofilin oxidation for oxidant-induced apoptosis.

Zdanov, Stéphanie; Klamt, Fábio; Shacter, Emily.

Cell Cycle ; 9(9): 1675-7, 2010 May.

Artigo em Inglês | MEDLINE | ID: mdl-20404500

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