Detalhe da pesquisa
1.
Next-generation bromodomain inhibitors of the SWI/SNF complex enhance DNA damage and cell death in glioblastoma.
J Cell Mol Med
; 27(18): 2770-2781, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37593885
2.
Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets.
J Chem Inf Model
; 63(13): 4070-4078, 2023 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37350740
3.
Genetic Variability of the SARS-CoV-2 Pocketome.
J Proteome Res
; 20(8): 4212-4215, 2021 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34180678
4.
Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.
Proteins
; 86(8): 833-843, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29569753
5.
Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474.
Biochem Biophys Res Commun
; 483(1): 502-508, 2017 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28007597
6.
A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.
Bioorg Med Chem
; 21(17): 5618-28, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23810672
7.
Retraction of "Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies".
ACS Med Chem Lett
; 14(10): 1482, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37849532
8.
Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.
Bioorg Med Chem
; 19(5): 1823-38, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21216604
9.
Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease.
Sci Rep
; 11(1): 23315, 2021 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34857794
10.
Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein.
Biochem Cell Biol
; 87(6): 825-33, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19935868
11.
Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics.
Front Oncol
; 7: 273, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29184849
12.
Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.
Chembiochem
; 10(12): 1959-64, 2009 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19644994
13.
Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma.
ACS Med Chem Lett
; 4(11): 1102-7, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900612
14.
Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies.
ACS Med Chem Lett
; 2(1): 79-84, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21243039
15.
Identification of NAE Inhibitors Exhibiting Potent Activity in Leukemia Cells: Exploring the Structural Determinants of NAE Specificity.
ACS Med Chem Lett
; 2(8): 577-82, 2011 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900352