Detalhe da pesquisa
1.
Triazolopyridazine LRRK2 kinase inhibitors.
Bioorg Med Chem Lett
; 23(7): 1967-73, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23454015
2.
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Bioorg Med Chem Lett
; 23(7): 1974-7, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23453068
3.
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg Med Chem Lett
; 23(7): 2181-6, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23465612
4.
Novel cinnoline-based inhibitors of LRRK2 kinase activity.
Bioorg Med Chem Lett
; 23(1): 71-4, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23219325
5.
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Bioorg Med Chem Lett
; 23(10): 3075-80, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23570791
6.
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(4): 996-1000, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23312944
7.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Bioorg Med Chem Lett
; 23(16): 4674-9, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856050
8.
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett
; 23(9): 2743-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23522834
9.
Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.
Bioorg Med Chem Lett
; 21(12): 3726-9, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21570836
10.
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg Med Chem Lett
; 21(6): 1838-43, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316234
11.
Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Bioorg Med Chem Lett
; 21(19): 5791-4, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21885276
12.
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorg Med Chem Lett
; 21(18): 5521-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813278
13.
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Bioorg Med Chem Lett
; 21(1): 315-9, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21112785
14.
Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2148-50, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20206516
15.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2195-9, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207136
16.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
Bioorg Med Chem Lett
; 20(12): 3502-6, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20529683
17.
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Bioorg Med Chem Lett
; 20(24): 7303-7, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21071223
18.
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Bioorg Med Chem Lett
; 20(21): 6231-6, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833041
19.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Bioorg Med Chem Lett
; 20(20): 6034-9, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20822903
20.
Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.
Bioorg Med Chem Lett
; 20(16): 4789-94, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20634069