RESUMO
The relationship between immune thrombocytopenia (ITP) and Helicobacterpylori infection has largely been an unexplored entity. This review article aims at focusing on the role of H. pylori in secondary ITP. We also elucidated the importance of diagnostic workup and treatment of H. pylori in this article. The mechanisms of H. pylori-associated ITP have been covered in this article. The factors determining platelet response to H. pylori eradication therapy have been mentioned. It is extremely crucial to be aware that H. pylori is a major causative pathogen for new-onset ITP as well as chronic ITP. Upper gastrointestinal endoscopic biopsy is the best invasive method for the diagnosis of the same. Further studies need to be conducted across larger, more diverse groups to validate our observation that eradication of H. pylori could aid platelet recovery in ITP.
RésuméObjectif: La relation entre ITP et l'infection à Helicobacterpylori a largement été un domaine inexploré. Cet article de revue vise à SE concentrer sur le rôle de H. pylori dans l'ITP secondaire. Nous avons également élucidé l'importance du bilan diagnostique et du traitement de H. pylori dans cet article. Les mécanismes de l'ITP associée à H. pylori ont été abordés dans cet article. Les facteurs déterminant la réponse des plaquettes à la thérapie d'éradication de H. pylori ont été mentionnés. Il est extrêmement crucial de prendre conscience que H. pylori est un pathogène causal majeur pour l'ITP de novo ainsi que pour l'ITP chronique. La biopsie endoscopique du tractus gastro-intestinal supérieur est la meilleure méthode invasive pour le diagnostic de la même pathologie. Des études ultérieures doivent être menées auprès de groupes plus vastes et plus diversifiés pour valider notre observation selon laquelle l'éradication de H. pylori pourrait favoriser la récupération des plaquettes dans l'ITP.
Assuntos
Antibacterianos , Infecções por Helicobacter , Helicobacter pylori , Púrpura Trombocitopênica Idiopática , Humanos , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/tratamento farmacológico , Infecções por Helicobacter/complicações , Helicobacter pylori/isolamento & purificação , Púrpura Trombocitopênica Idiopática/diagnóstico , Púrpura Trombocitopênica Idiopática/terapia , Antibacterianos/uso terapêutico , Resultado do TratamentoRESUMO
Acute interstitial nephritis (AIN) is a rare but serious adverse effect reported with proton pump inhibitors (PPIs). Only one report (2 cases) of AIN with lansoprazole is published in literature. A case of lansoprazole induced interstitial nephritis (biopsy supported) was reported in an elderly female patient admitted to the hospital with non specific symptoms after 45 days of treatment with the drug. A recovery was noticed upon withdrawal of the drug and treatment with corticosteroids. We consider this report as a valuable addition to the existing literature on this rare adverse effect with lansoprazole. This potentially serious adverse effect with PPIs including lansoprazole has to be given due consideration, especially taking into account the wide spread use of this group of agents.