Detalhe da pesquisa
1.
Interdisciplinary model-informed drug development for extending duration of elagolix treatment in patients with uterine fibroids.
Br J Clin Pharmacol
; 88(12): 5257-5268, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35695781
2.
Physiologically based pharmacokinetic modeling and simulations to inform dissolution specifications and clinical relevance of release rates on elagolix exposure.
Biopharm Drug Dispos
; 43(3): 98-107, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35405765
3.
Accelerating drug development in pediatric cancer: a novel Phase I study design of venetoclax in relapsed/refractory malignancies.
Future Oncol
; 14(21): 2115-2129, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29595064
4.
Guiding dose adjustment of amlodipine after co-administration with ritonavir containing regimens using a physiologically-based pharmacokinetic/pharmacodynamic model.
J Pharmacokinet Pharmacodyn
; 45(3): 443-456, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29427135
5.
Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir.
Drug Metab Dispos
; 45(7): 755-764, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28483778
6.
Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective.
Drug Metab Dispos
; 44(10): 1720-30, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27422672
7.
Ubrogepant: Mechanism of action, clinical and translational science.
Clin Transl Sci
; 17(1): e13675, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266060
8.
Atogepant: Mechanism of action, clinical and translational science.
Clin Transl Sci
; 17(1): e13707, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266063
9.
Bioequivalence of Elagolix/Estradiol/Norethindrone Acetate Fixed-Dose Combination Product: Phase 1 Results in Healthy Pre- and Postmenopausal Women.
Clin Pharmacol Drug Dev
; 13(6): 601-610, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593267
10.
Phase 2, double-blind, randomized, placebo-controlled study of the safety and efficacy of elagolix in women with polycystic ovary syndrome.
F S Rep
; 4(2): 206-212, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398623
11.
Virtual Bioequivalence Assessment of Elagolix Formulations Using Physiologically Based Pharmacokinetic Modeling.
AAPS J
; 25(3): 30, 2023 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36949256
12.
Phase 1 study of safety, pharmacokinetics, and antiviral activity of SARS-CoV-2 neutralizing monoclonal antibody ABBV-47D11 in patients with COVID-19.
Pharmacol Res Perspect
; 11(1): e01036, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36537346
13.
Effects of elagolix on the pharmacokinetics of omeprazole and its metabolites in healthy premenopausal women.
Clin Transl Sci
; 15(5): 1269-1280, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35137535
14.
Population Pharmacokinetics of Elagolix in Combination with Low-Dose Estradiol/Norethindrone Acetate in Women with Uterine Fibroids.
Clin Pharmacokinet
; 61(4): 577-587, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34878624
15.
A Personalized Medicine Approach Using Clinical Utility Index and Exposure-Response Modeling Informed by Patient Preferences Data.
CPT Pharmacometrics Syst Pharmacol
; 10(1): 40-47, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33200566
16.
Drug-Drug Interaction Studies of Elagolix with Oral and Transdermal Low-Dose Hormonal Add-Back Therapy.
Clin Pharmacokinet
; 60(1): 133-143, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32696440
17.
Mechanistic Modeling of Intra-Tumor Spatial Distribution of Antibody-Drug Conjugates: Insights into Dosing Strategies in Oncology.
Clin Transl Sci
; 14(1): 395-404, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33073529
18.
Bone Mineral Density Changes Associated With Pregnancy, Lactation, and Medical Treatments in Premenopausal Women and Effects Later in Life.
J Womens Health (Larchmt)
; 30(10): 1416-1430, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34435897
19.
Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis.
Clin Transl Sci
; 14(4): 1611-1619, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33963686
20.
Integrating real-world data and modeling to project changes in femoral neck bone mineral density and fracture risk in premenopausal women.
Clin Transl Sci
; 14(4): 1452-1463, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33650259