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1.
Eur Rev Med Pharmacol Sci ; 28(9): 3330-3346, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38766791

RESUMO

OBJECTIVE: Malvidin is a natural, biologically active polyphenol found in several fruits. It exhibits several therapeutic benefits; however, limited studies are available on its effects on neurodegenerative clinical conditions, including Parkinson's disease. The study aimed to investigate the therapeutic properties of malvidin on rotenone-triggered Parkinson's disease in an animal model. MATERIALS AND METHODS: To determine the effects of malvidin, rotenone (1.5 mg/kg) was injected subcutaneously into Wistar rats for 21 days, followed by a dose of malvidin (200 and 100 mg/kg). Behavioral tests were performed on the experimental animals before sacrifice. On the 22nd day of the experiment, biochemical tests were performed, including superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and catalase (CAT). The activity of neurotransmitters and their metabolites, including acetylcholine (ACh), acetylcholinesterase (AChE), dopamine (DA), norepinephrine (NE), serotonin (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) along with neuroinflammatory markers including interleukin-6 (IL-6), interleukin-1ß (IL-1ß), tumor necrosis factor- α (TNF-α), and nuclear factor erythroid 2-related factor 2 (Nrf-2) were estimated. Moreover, the level of the apoptotic marker, caspase-3, was also estimated. In addition, molecular docking was performed. RESULTS: The administration of rotenone resulted in oxidative stress, cholinergic imbalances, dopaminergic alternations, and increased expression of inflammatory compounds. The docking analysis revealed that malvidin displayed a favorable binding affinity for AChE, showcasing a binding energy of -9.329 Kcal/mol. CONCLUSIONS: The investigation concludes that malvidin exhibits neuroprotective effects due to its curative effects against inflammation and oxidative stress. These findings suggest that malvidin possesses therapeutic potential against rotenone-triggered behavioral, oxidative, and inflammatory abnormalities in rodents.


Assuntos
Caspase 3 , Simulação de Acoplamento Molecular , Fator 2 Relacionado a NF-E2 , Rotenona , Fator de Necrose Tumoral alfa , Animais , Masculino , Ratos , Comportamento Animal/efeitos dos fármacos , Caspase 3/metabolismo , Modelos Animais de Doenças , Fármacos Neuroprotetores/farmacologia , Fator 2 Relacionado a NF-E2/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Ratos Wistar , Fator de Necrose Tumoral alfa/metabolismo
2.
Eur Rev Med Pharmacol Sci ; 28(1): 419-432, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38235894

RESUMO

OBJECTIVE: Anxiety and depression are common psychiatric disorders that affect millions of people worldwide. Lipopolysaccharide (LPS) is a bacterial endotoxin that has been demonstrated to cause depression and anxiety-like behaviors in animal models. Fustin is a flavonoid found in various plant species that have been reported to have neuroprotective effects. The study proposed the evaluation of fustin's impact on anxiety and depression in LPS-injected rats. MATERIALS AND METHODS: The efficacy of fustin in higher and lower doses was studied by administering a single dose of LPS-injected anxiety/depression in rodents. Behavioral models like the elevated plus maze test, open field test, marble burying test, force swimming test, tail suspension test, and hyperemotionality behavior were performed to evaluate anxiety/depression in rodents. The neuroinflammatory markers such as interleukin-6 (IL-6), interleukin-1ß (IL-1ß), nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), apoptosis marker caspase-3, and brain-derived neurotrophic factor (BDNF) were also measured as a part of the study. Additionally, biochemical markers of oxidative stress, such as malonaldehyde (MDA) and antioxidants, including superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and nitric oxide (NO), were also evaluated. RESULTS: LPS administration resulted in significant (p<0.001) changes in behavior tests and biochemical markers including IL-1ß, IL-6, NF-κB, TNF-α, NO, caspase-3, BDNF, MDA, CAT, SOD, and GSH. In contrast, treating the rats with fustin significantly improved the behavior tests and restored the changes in biochemical markers. CONCLUSIONS: The current work established the efficacy of fustin with its therapeutic impact on depression and anxiety-like behaviors in rodent experimental models through its modulation of apoptosis markers, oxidative stress, and neuroinflammation.


Assuntos
Depressão , Flavonoides , NF-kappa B , Animais , Ratos , Ansiedade/tratamento farmacológico , Biomarcadores/metabolismo , Fator Neurotrófico Derivado do Encéfalo/metabolismo , Caspase 3/metabolismo , Depressão/induzido quimicamente , Depressão/tratamento farmacológico , Depressão/metabolismo , Flavonoides/farmacologia , Interleucina-6/metabolismo , Lipopolissacarídeos/efeitos adversos , Doenças Neuroinflamatórias , NF-kappa B/metabolismo , Estresse Oxidativo , Roedores/metabolismo , Superóxido Dismutase/metabolismo , Fator de Necrose Tumoral alfa/metabolismo
3.
Eur Rev Med Pharmacol Sci ; 28(3): 981-994, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38375702

RESUMO

OBJECTIVE: Recent research suggests that butin may also exert neuroprotective effects. However, its influence on cognitive performance and, specifically, its potential to mitigate scopolamine-induced memory impairment remains unexplored. The aim of the study is to investigate the effects of butin on the cognitive and behavioral performance of rats with scopolamine-induced memory impairment. MATERIALS AND METHODS: Scopolamine-injected memory-impediment model in rats was used to determine the efficacy of butin in higher and lower doses (10 and 20 mg/kg) for 14 days. Y-maze, along with Morris water, was used to assess the ability to recall spatial and working information. Biochemistry-related functions such as acetylcholinesterase, choline acetyltransferase, superoxide dismutase, glutathione transferase, malonaldehyde, catalase, nitric oxide, and neurotransmitters levels were estimated as indicators of free radical damage. Furthermore, we evaluated neuro-inflammatory responses by assessing tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1ß), interleukin-6 (IL-6), brain-derived neurotrophic factor (BDNF) and caspase-3 immuno-reactive proteins. RESULTS: When assessed through behavioral paradigms, the butin-treated group enhanced the spatial and working memory of rodents. Scopolamine caused a substantial alteration in biochemical-related parameters, neuronal enzymatic, inflammation responses and apoptosis markers prominently restored by butin. CONCLUSIONS: This study concludes that butin protects scopolamine-injected rats from behavioral impairments and neuronal damage by reducing apoptosis and neuroinflammation.


Assuntos
Benzopiranos , Fator Neurotrófico Derivado do Encéfalo , Escopolamina , Animais , Ratos , Acetilcolinesterase/metabolismo , Benzopiranos/farmacologia , Fator Neurotrófico Derivado do Encéfalo/metabolismo , Caspase 3/metabolismo , Hipocampo/metabolismo , Aprendizagem em Labirinto , Transtornos da Memória/induzido quimicamente , Transtornos da Memória/tratamento farmacológico , Transtornos da Memória/metabolismo , Estresse Oxidativo , Escopolamina/efeitos adversos
4.
Braz J Med Biol Res ; 57: e12829, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38359270

RESUMO

This study was conducted to evaluate how sterubin affects rotenone-induced Parkinson's disease (PD) in rats. A total of 24 rats were distributed into 4 equal groups: normal saline control and rotenone control were administered saline or rotenone (ROT), respectively, orally; sterubin 10 received ROT + sterubin 10 mg/kg po; and sterubin alone was administered to the test group (10 mg/kg). Rats of the normal saline and sterubin alone groups received sunflower oil injection (sc) daily, 1 h after receiving the treatments cited above, while rats of the other groups received rotenone injection (0.5 mg/kg, sc). The treatment was continued over the course of 28 days daily. On the 29th day, catalepsy and akinesia were assessed. The rats were then euthanized, and the brain was extracted for estimation of endogenous antioxidants (MDA: malondialdehyde, GSH: reduced glutathione, CAT: catalase, SOD: superoxide dismutase), nitrative (nitrite) stress markers, neuroinflammatory cytokines, and neurotransmitter levels and their metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), dopamine (DA), norepinephrine (NE), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA)). Akinesia and catatonia caused by ROT reduced the levels of endogenous antioxidants (GSH, CAT, and SOD), elevated the MDA level, and altered the levels of nitrites, neurotransmitters, and their metabolites. Sterubin restored the neurobehavioral deficits, oxidative stress, and metabolites of altered neurotransmitters caused by ROT. Results demonstrated the anti-Parkinson's activities of sterubin in ROT-treated rats.


Assuntos
Fármacos Neuroprotetores , Doença de Parkinson , Ratos , Animais , Doença de Parkinson/tratamento farmacológico , Doença de Parkinson/prevenção & controle , Antioxidantes/farmacologia , Rotenona/farmacologia , Solução Salina/farmacologia , Estresse Oxidativo , Neurotransmissores/metabolismo , Neurotransmissores/farmacologia , Superóxido Dismutase , Modelos Animais de Doenças
5.
Eur Rev Med Pharmacol Sci ; 27(24): 12029-12042, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38164865

RESUMO

OBJECTIVE: The objective of the study was to assess the protective effects of barbigerone in ethanol-induced gastric ulcers in rats. MATERIALS AND METHODS: Male Wistar rats (180±20 g) were used in the study (n=06). The rats were randomly divided into different groups, i.e., the normal group, ethanol control, and barbigerone 10 and 20 mg/kg group. Various biochemical parameters were assessed - total acidity and pH values, oxidative stress biomarkers such as superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and catalase (CAT) along with markers, i.e., tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1ß, intercellular adhesion molecule-1 (ICAM-1) and expression of B-Cell Leukemia/Lymphoma 2 (Bcl-2). Also, histopathology was performed. RESULTS: Treatment with barbigerone in the ethanol-induced-ulcer rats restored the levels of biochemical parameters such as SOD, GSH, MDA, CAT, and markers expression, including TNF-α, IL-6, IL-1ß, ICAM-1, and Bcl-2 with protected against cellular necrosis. CONCLUSIONS: Barbigerone protective effects can be attributed to its ability to reduce oxidative stress and inflammation, as well as promote gastroprotection against ethanol-induced ulcers in rats.


Assuntos
Fator de Necrose Tumoral alfa , Úlcera , Ratos , Masculino , Animais , Fator de Necrose Tumoral alfa/metabolismo , Interleucina-6/metabolismo , Molécula 1 de Adesão Intercelular/metabolismo , Etanol/toxicidade , Ratos Wistar , Antioxidantes/farmacologia , Antioxidantes/metabolismo , Estresse Oxidativo , Glutationa/metabolismo , Superóxido Dismutase/metabolismo , Interleucina-1beta/metabolismo
6.
Braz. j. med. biol. res ; 57: e12829, fev.2024. graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1534064

RESUMO

This study was conducted to evaluate how sterubin affects rotenone-induced Parkinson's disease (PD) in rats. A total of 24 rats were distributed into 4 equal groups: normal saline control and rotenone control were administered saline or rotenone (ROT), respectively, orally; sterubin 10 received ROT + sterubin 10 mg/kg po; and sterubin alone was administered to the test group (10 mg/kg). Rats of the normal saline and sterubin alone groups received sunflower oil injection (sc) daily, 1 h after receiving the treatments cited above, while rats of the other groups received rotenone injection (0.5 mg/kg, sc). The treatment was continued over the course of 28 days daily. On the 29th day, catalepsy and akinesia were assessed. The rats were then euthanized, and the brain was extracted for estimation of endogenous antioxidants (MDA: malondialdehyde, GSH: reduced glutathione, CAT: catalase, SOD: superoxide dismutase), nitrative (nitrite) stress markers, neuroinflammatory cytokines, and neurotransmitter levels and their metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), dopamine (DA), norepinephrine (NE), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA)). Akinesia and catatonia caused by ROT reduced the levels of endogenous antioxidants (GSH, CAT, and SOD), elevated the MDA level, and altered the levels of nitrites, neurotransmitters, and their metabolites. Sterubin restored the neurobehavioral deficits, oxidative stress, and metabolites of altered neurotransmitters caused by ROT. Results demonstrated the anti-Parkinson's activities of sterubin in ROT-treated rats.

7.
East Mediterr Health J ; 13(5): 1212-5, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18290416

RESUMO

In February 2004, 4 patients aged 10-15 years presented at the Pakistan Institute of Medical Sciences with non-healing multiple ulcers on exposed parts. On the basis of history, clinical assessment and fine needle aspiration cytology, they were diagnosed as having cutaneous leishmaniasis. We were informed that several similar cases were present in their village. A team of doctors and technicians visited the area. A survey was conducted and another 105 cases with various morphological presentations were identified. The area was visited several times to find the vector, reservoirs and source of infection and to advise on controlling the epidemic.


Assuntos
Surtos de Doenças , Leishmaniose Cutânea , Adolescente , Distribuição por Idade , Animais , Antiprotozoários/uso terapêutico , Biópsia por Agulha , Criança , Efeitos Psicossociais da Doença , Surtos de Doenças/prevenção & controle , Surtos de Doenças/estatística & dados numéricos , Reservatórios de Doenças/parasitologia , Doenças Endêmicas/prevenção & controle , Doenças Endêmicas/estatística & dados numéricos , Humanos , Controle de Insetos , Insetos Vetores , Leishmaniose Cutânea/diagnóstico , Leishmaniose Cutânea/epidemiologia , Leishmaniose Cutânea/prevenção & controle , Leishmaniose Cutânea/transmissão , Meglumina/uso terapêutico , Antimoniato de Meglumina , Avaliação das Necessidades , Compostos Organometálicos/uso terapêutico , Paquistão/epidemiologia , Vigilância da População , Sistema de Registros , Saúde da População Rural/estatística & dados numéricos , Gerenciamento de Resíduos
8.
Pancreas ; 18(3): 316-21, 1999 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10206491

RESUMO

Sclerosing mesenteritis is an uncommon nonneoplastic inflammatory process in the mesentery that is seen as a pseudotumor, usually involving the small bowel mesentery, the mesenteric fat, and less commonly, the mesentery of the large bowel. We report two cases of sclerosing mesenteritis and review the literature on this rare disease. Both patients had pain, profound weight loss, and a mass on computed tomography (CT) scan of the abdomen. The provisional diagnosis was pancreatic neoplasm on the basis of clinical presentation and imaging studies. The diagnosis of sclerosing mesenteritis was established by histologic findings in biopsy material obtained at laparotomy in both cases. Interval histologic studies in one patient who had a high CA 19-9 level, progressive biliary ductal and partial duodenal compression, revealed a transitional histologic pattern from predominant inflammation and fat necrosis to predominant fibrosis. This may explain the varied descriptive terms used in the literature to describe this entity.


Assuntos
Mesentério , Neoplasias Pancreáticas , Peritonite/diagnóstico , Dor Abdominal , Idoso , Biópsia , Antígeno CA-19-9/análise , Diagnóstico Diferencial , Necrose Gordurosa , Fibrose , Humanos , Masculino , Mesentério/patologia , Peritonite/patologia , Tomografia Computadorizada por Raios X , Redução de Peso
9.
J Gastroenterol ; 36(9): 629-32, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11578068

RESUMO

Pseudomembranous colitis usually presents with diarrhea in a clinical setting of recent antibiotic use. It is uncommon to see it as a cause of obstipation and colonic pseudo-obstruction. We report an unusual case of an elderly woman with hypertension, congestive heart failure, chronic obstructive pulmonary disease, chronic renal insufficiency, and diabetes mellitus, who was admitted with fever, abdominal pain, and distension without diarrhea. She presented with decreased stool frequency and obstipation. She did not respond to conservative management. Colonoscopy revealed a picture of pseudomembranous colitis, and Clostridium difficile toxin was positive. She responded well to metronidazole therapy.


Assuntos
Pseudo-Obstrução do Colo/etiologia , Enterocolite Pseudomembranosa/complicações , Idoso , Anti-Infecciosos/uso terapêutico , Biópsia , Pseudo-Obstrução do Colo/diagnóstico por imagem , Pseudo-Obstrução do Colo/tratamento farmacológico , Colonoscopia/métodos , Meios de Contraste , Complicações do Diabetes , Diatrizoato de Meglumina , Enema , Enterocolite Pseudomembranosa/diagnóstico por imagem , Enterocolite Pseudomembranosa/tratamento farmacológico , Feminino , Insuficiência Cardíaca/complicações , Humanos , Hipertensão/complicações , Falência Renal Crônica/complicações , Metronidazol/uso terapêutico , Doença Pulmonar Obstrutiva Crônica/complicações , Tomografia Computadorizada por Raios X/métodos
10.
Talanta ; 21(6): 401-9, 1974 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18961476

RESUMO

The inhibition of isocitrate dehydrogenase by lead, indium and calcium has been studied. Methods for the determination of 0.024-1 mug of lead and indium, based on this inhibition, are outlined. Lead may be separeted from some interfering ions by extraction with tributyl phosphate in isobutyl methyl ketone, before application of the enzymic reaction.

11.
Ann Saudi Med ; 15(6): 619-21, 1995 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17589023

RESUMO

This prospective epidemiological study was done at King Abdul Aziz Hospital, Madinah Al-Munawarah, during the 1993 Haj season, to identify the medical problems of pilgrims. Out of 23,806 pilgrims who attentded this hospital during the study period, 773 (3.25%) were admitted as medical cases. Mean age of admitted cases were 60.4 +/- 11.4 years. Pneumonia (45.8%), diabetes mellitus (20.7%) and ischemic heart disease (15.3%) were the most common diseases among pilgrims. Respiratory, cardiovascular and metabolic diseases affected 74%, 57% and 23% of the pilgrims. There were 57 deaths, with a mortality rate of 7.4%. Myocardial infarction was the most common cause of death. A large number of cases (32.6%) discharged themselves against medical advice. Old age, poor physical fitness, multiple diseases, neglect in continous treatment of known chronic diseases and failure to seek early medical advice were the major factors responsible for morbidity and mortality.

13.
J Matern Fetal Med ; 10(2): 91-6, 2001 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11392599

RESUMO

OBJECTIVE: The purpose of this study was to examine pregnancy outcomes in women with systemic lupus erythematosus (SLE). STUDY DESIGN: Data from the California Health Information for Policy Project, which links records from birth certificates and hospital discharge records of mothers and newborns who delivered in all civilian hospitals in the state of California between 1 January 1993 and 31 December 1994, were retrospectively reviewed. Patients with a singleton gestation were stratified into the study group if they had a diagnosis of SLE, based on the International Classification of Disease, 9th Revision, or into the control group if they did not have SLE and delivered during the interval from 1 January 1994 to 31 December 1994. Specific maternal outcomes including pregnancy complications and fetal and neonatal outcomes were assessed and compared between the two groups. RESULTS: During the 2-year study period, 555 women had a diagnosis of SLE, and approximately 600000 women were included in the control group in the year 1994, giving a point prevalence of 0.05%. Specific adverse pregnancy outcomes, including hypertensive complications, renal disease, preterm delivery, non-elective Cesarean section, postpartum hemorrhage and delivery-related deep vein thrombosis all occurred more frequently in the SLE group as compared to controls (p < 0.001). Additionally, neonatal and fetal outcomes were significantly worse in the SLE group, as documented by a higher prevalence of fetal growth restriction and neonatal death, as well as longer hospital stays (p < 0.0001). CONCLUSION: SLE was associated with a significant increase in maternal pregnancy complications and in fetal and neonatal morbidity and mortality as compared to the control population. However, our population-based study found significantly fewer adverse outcomes than were previously reported. This may represent a more accurate clinical picture of the impact of SLE on pregnancy outcomes.


Assuntos
Lúpus Eritematoso Sistêmico/epidemiologia , Complicações na Gravidez/epidemiologia , Resultado da Gravidez/epidemiologia , Adulto , California/epidemiologia , Feminino , Humanos , Lúpus Eritematoso Sistêmico/complicações , Prontuários Médicos , Gravidez , Prevalência , Estudos Retrospectivos
14.
Am J Gastroenterol ; 95(9): 2364-71, 2000 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11007244

RESUMO

Microsporidia are increasingly recognized as opportunistic infections in immunodeficient patients, predominantly patients with AIDS. The two microsporidia most commonly associated with disease in AIDS patients are Enterocytozoon bieneusi and Encephalitozoon intestinalis (previously known as Septata intestinalis). The most common clinical presentation of microsporidiosis in AIDS patients is diarrhea, most commonly caused by the Enterocytozoon bieneusi species. Encephalitozoon intestinalis is a recently described species that has been reported to cause disseminated human infection including cholangitis. We report a case of AIDS cholangiopathy that presented with abdominal pain and cholestatic liver tests. Ultrasound examination and ERCP revealed a picture of sclerosing cholangitis. Bile samples obtained at ERCP were negative for microsporidia; stool studies for microsporidia and cryptosporidia were also negative. No organisms were identified on routine light microscopy of the biopsy specimens from the duodenum, ampulla, and bile duct. E. intestinalis spores were demonstrated in the bile duct biopsies, by methylene blue and azure 11 staining and confirmed by electron microscopy. Albendazole therapy was successful in eradicating E. intestinalis with clinical improvement and improvement in CD4 count. However, the cholangiographic picture did not improve and repeat cholangiography revealed progressive bile duct injury. Albendazole therapy was delayed and may have been too late to prevent bile duct damage; the drug had to be approved by the US Food and Drug Administration for compassionate use. This is an unusual case of sclerosing cholangitis caused by an unusual organism and requiring biliary sphincterotomy and stent placement for progressive stricturing despite eradication of the infection.


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/parasitologia , Colangite Esclerosante/parasitologia , Encephalitozoon/isolamento & purificação , Encefalitozoonose/parasitologia , Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Adulto , Albendazol/uso terapêutico , Animais , Antiprotozoários/uso terapêutico , Ductos Biliares/parasitologia , Ductos Biliares/ultraestrutura , Biópsia por Agulha , Colangiopancreatografia Retrógrada Endoscópica , Colangite Esclerosante/diagnóstico , Colangite Esclerosante/tratamento farmacológico , Diagnóstico Diferencial , Encefalitozoonose/diagnóstico , Encefalitozoonose/tratamento farmacológico , Humanos , Masculino
15.
J Clin Gastroenterol ; 28(4): 323-8, 1999 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10372929

RESUMO

Subcapsular hemorrhage and hepatic rupture are unusual catastrophic complications of the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. A high index of suspicion and prompt recognition are keys to proper diagnosis and management of affected patients. The optimal management of these patients is evolving. An aggressive multidisciplinary approach has considerably improved the morbidity and mortality associated with these complications. We present our experience with four cases of hepatic hemorrhage occurring in association with the HELLP syndrome and review the literature on this subject. All of our patients were multiparous, and three had a history of eclampsia/preeclampsia in a previous pregnancy. All four patients developed intrahepatic hemorrhage; two developed hepatic rupture requiring surgical intervention. Three patients developed disseminated intravascular coagulation and acute renal failure. Two patients developed pericardial effusion, pleural effusions, and ascites. One patient died of septic complications after multiple surgical interventions.


Assuntos
Síndrome HELLP/complicações , Hemorragia/complicações , Hemorragia/diagnóstico , Hepatopatias/complicações , Hepatopatias/diagnóstico , Complicações Hematológicas na Gravidez/diagnóstico , Adulto , Diagnóstico Diferencial , Feminino , Hemorragia/epidemiologia , Hemorragia/mortalidade , Hemorragia/terapia , Humanos , Hepatopatias/epidemiologia , Hepatopatias/mortalidade , Hepatopatias/terapia , Gravidez , Complicações Hematológicas na Gravidez/terapia , Prognóstico , Ruptura Espontânea , Tomografia Computadorizada por Raios X
16.
Emerg Infect Dis ; 6(2): 171-4, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10756151

RESUMO

We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other gastrointestinal disorders. The organism was detected in 11 (13.2%) of 83 patients with inflammatory bowel disease. Of 57 patients with active disease, 19.3% were toxin positive; none of those with inactive disease had specimens positive for enterotoxigenic Bacteroides fragilis gene sequences.


Assuntos
Bacteroides fragilis/genética , Bacteroides fragilis/patogenicidade , Enterotoxinas/genética , Genes Bacterianos , Doenças Inflamatórias Intestinais/microbiologia , Metaloendopeptidases/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Infecções por Bacteroides/etiologia , Infecções por Bacteroides/microbiologia , Estudos de Casos e Controles , Criança , DNA Bacteriano/genética , DNA Bacteriano/isolamento & purificação , Fezes/microbiologia , Feminino , Humanos , Doenças Inflamatórias Intestinais/etiologia , Masculino , Pessoa de Meia-Idade
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