Raman-shifted wavelength-selectable pulsed fiber laser with high repetition rate and high pulse energy in the visible.

A high-pulse-energy, diffraction-limited, wavelength-selectable, visible source, based on Raman frequency shifting of a frequency-doubled Yb-doped fiber laser, has been studied. The relative length-scaling laws of Raman gain and self-phase modulation push the design towards short fiber lengths with large core size. It is experimentally demonstrated that the Raman clean-up effect in a graded-index multi-mode fiber is not sufficient to obtain diffraction-limited beam quality in the short fiber length. Thus, a large-core photonic crystal fiber is used to maintain diffraction-limited performance and output pulse energies of ~1 µJ, at a 1-MHz repetition rate and 1.3-ns pulse-width are successfully achieved. This step-tunable visible source should find applications in photoacoustic microscopy.

Thulium-fiber-laser-pumped, high-peak-power, picosecond, mid-infrared orientation-patterned GaAs optical parametric generator and amplifier.

We report a high-peak-power, picosecond, mid-infrared optical parametric generator (OPG) and optical parametric amplifier (OPA) based on orientation-patterned gallium arsenide pumped by a thulium:fiber master-oscillator-power-amplifier employing direct diode-seeded amplification. An OPG tuning range of 2550-2940 nm (signal) and 5800-8300 nm (idler) is demonstrated with peak powers as high as 3 (signal) and 2 kW (idler), and with pulse energies of 0.26 and 0.16 µJ, respectively. When seeded with a 0.6 cm-1 linewidth tunable Cr:ZnSe laser, the OPA idler linewidth is narrowed to 1.4 cm-1 and a small-signal parametric gain of 60 dB is achieved. A maximum peak power of 13.3 (signal) and 3.2 kW (idler) is obtained at an overall conversion efficiency of 36%. The corresponding maximum pulse energies for the signal and idler are 1.07 and 0.26 µJ, respectively.

Fiber-laser-pumped, high-energy, mid-IR, picosecond optical parametric oscillator with a high-harmonic cavity.

We demonstrate the generation of high-energy, mid-IR, picosecond pulses in a high-harmonic-cavity optical parametric oscillator (OPO) that has a relatively compact cavity with a length that is a small fraction of that required to match the pump repetition rate. The OPO, based on an MgO-doped periodically poled LiNbO3 crystal, is pumped by a fiber master-oscillator-power-amplifier system employing direct amplification and delivering 11-µJ, 150-ps pulses at 1035 nm. For a 1.554-m-long OPO cavity, resonating near-infrared signal pulses with a repetition rate that is the 193rd harmonic of the 1-MHz pump are demonstrated. The mid-infrared idler output pulses, tunable from 2300 nm to 3500 nm, are generated at a 1-MHz repetition rate and have energies as high as 1.5 µJ.

Diode-pumped femtosecond solid-state waveguide laser with a 4.9 GHz pulse repetition rate.

We report on the first demonstration of a passively mode-locked, diode-pumped, monolithic Yb:glass channel waveguide laser that incorporates a semiconductor saturable absorber mirror. Stable and self-starting mode-locking is achieved in a Fabry-Perot cavity configuration producing a pulse repetition rate up to 4.9 GHz. The shortest pulse duration of 740 fs is generated with 30 mW of average output power at a center wavelength of 1058 nm. A maximum output power of 81 mW is produced during mode-locking with corresponding pulse duration of 800 fs.

High energy femtosecond fiber chirped pulse amplification system with adaptive phase control.

We demonstrate increased peak power from an Yb fiber CPA system operating with strong self-phase modulation by shaping the spectral-phase of the input pulses. An adaptive control loop used feedback from the output autocorrelation. We investigated pre-compensation of both SPM phase distortion at high energies, and residual dispersion from mismatched stretcher/compressor technologies at low energies. Phase shaping resulted in improved pulse quality. When using a bulk grating stretcher, shaping increased the autocorrelation peak by a factor of 2.9, and with a fiber stretcher, shaping increased the autocorrelation peak by a factor of 3.4. High-quality 800 fs, 65 microJ recompressed pulses were produced. This technique could benefit a wide variety of fiber amplifier systems and is self-optimising for operation at both low and high pulse energies.

Intra-cavity side-pumped Ho:YAG laser.

We present a novel, compact and power scalable Ho:YAG laser based on intracavity side-pumping by a high-power Tm:YLF slab laser. 14 W of continuous wave output power is obtained at 2.09 microm in the current experiments, with the clear prospect of reaching the 100 W regime in a power scaled version.

Room-temperature continuous-wave operation of Ti:sapphire buried channel-waveguide lasers fabricated via proton implantation.

Fabrication and laser operation of proton-implanted Ti:sapphire buried channel waveguides is reported for the first time to our knowledge. Without any postimplantation annealing of the structures, continuous laser operation near 780 nm was demonstrated at room temperature at an absorbed pump power threshold of 230 mW. Single-transverse-mode laser emission was observed with measured beam propagation factors M(2)(x) and M(2)(y) of 1.5 and 1.2, respectively. An output power of 12.4 mW for 1 W pump power was obtained with an output coupler of 4.6% transmission at the signal wavelength. Higher output powers were measured in waveguides with larger cross sections exhibiting multimode laser emission.

End-pumped, passively Q-switched Yb:YAG double-clad waveguide laser.

We present a diode-pumped, double-clad Yb:YAG waveguide laser that contains an integrated section of a Cr(4+): YAG saturable absorber for passive Q switching. Using two 4-W polarization-coupled, broad-striped diode-pumped lasers, we obtained 30-microJ pulses of 1.6-ns duration at repetition rates of as much as 77 kHz. The slope efficiency was ~50% with respect to absorbed pump power, with a maximum output average power of 2.3 W and a peak power of ~18 kW . The output beam was single lobed, with M(2) values as great as 1.5x1.3 . We also demonstrate a passively Q -switched Nd:YAG waveguide laser of similar design, operating at 1.064 microm and 946 nm.

An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen.

BACKGROUND: Existing murine models of asthma lack many of the inflammatory and epithelial changes that are typical of the human disease. Moreover, these models are frequently complicated by allergic alveolitis. METHODS: High IgE responder BALB/c mice were systemically sensitised to ovalbumin and chronically challenged with low particle mass concentrations of aerosolised ovalbumin. Titres of antiovalbumin IgE in serum were measured at two weekly intervals by enzyme immunoassay, accumulation of inflammatory cells and histopathological abnormalities of the epithelium were quantified morphometrically in the trachea and the lungs, and airway reactivity was assessed by measuring bronchoconstriction following intravenous administration of methacholine. RESULTS: Mice sensitised by two intraperitoneal injections of ovalbumin developed high titres of IgE antibodies to ovalbumin. Following exposure to low concentrations of aerosolised antigen for up to eight weeks these animals developed a progressive inflammatory response in the airways, characterised by the presence of intraepithelial eosinophils and by infiltration of the lamina propria with lymphoid/mononuclear cells, without associated alveolitis. Goblet cell hyperplasia/metaplasia was induced in the intrapulmonary airways, while epithelial thickening and subepithelial fibrosis were evident following chronic exposure. In parallel, the mice developed increased sensitivity to induction of bronchospasm, as well as increased maximal reactivity. Non-immunised mice exposed to aerosolised ovalbumin had low or absent antiovalbumin IgE and did not exhibit inflammatory or epithelial changes, but developed airway hyperreactivity. CONCLUSIONS: This experimental model replicates many of the features of human asthma and should facilitate studies of pathogenetic mechanisms and of potential therapeutic agents.

Continuous-wave broadband emitter based on a transition-metal-ion-doped waveguide.

We demonstrate the suitability of a simple continuous-wave-pumped transition-metal-ion-doped waveguide as a broadband light source in the wavelength region 600-1000 nm for interferometric applications. Spatially coherent (single mode in the confined direction), spectrally broadband (~130-nm FWHM) luminescence with output powers of several hundreds of microwatts is obtained from a Ti:sapphire planar waveguide with incident pump powers from an Ar-ion laser of up to 1 W. This result represents an increase in power by several orders of magnitude from previously reported simple broadband light sources in this wavelength range.

Longitudinally diode-pumped Nd:YAG double-clad planar waveguide laser.

We report the demonstration of a near-diffraction-limited, compact, diode-end-pumped double-clad planar waveguide Nd:YAG laser. Efficient laser operation was achieved for the three dominant Nd(3+) transitions, at 1.064, 0.946, and 1.32microm , with TE polarized output powers of 1.33, 0.57, and 0.33 W for the available output couplers. The output beam from the monolithic plane-plane laser cavity had measured M(2) values of 1.0 and 1.8 perpendicular and parallel, respectively, to the plane of the waveguide.

Synchronously pumped CdSe optical parametric oscillator in the 9-10 microm region.

Continuous mode-locked operation of a singly resonant, synchronously pumped optical parametric oscillator (SPOPO) based on CdSe has produced idler output tuned over the range of 9.1-9.7 microm, the longest wavelength generated so far to our knowledge from a SPOPO. Average idler powers as high as approximately 70 mW are generated in the crystal. Tandem pumping with a diffraction-grating-tuned parametric oscillator in periodically poled lithium niobate provides a convenient and agile means of tuning the noncritically phase-matched CdSe device. The absence of any detrimental thermal effects in the CdSe crystal suggests that significant further power scaling should be possible, with idler tuning ranges extendable to cover 8-12 microm.

Compact diode-pumped passively Q-switched tunable Er-Yb double-clad fiber laser.

Efficient repetitive passive Q switching of a cladding-pumped Er-Yb fiber laser has been demonstrated by use of an external-cavity configuration containing a Co(2+): ZnS crystal as a saturable absorber. Energies of as much as 60muJ in pulses of durations as short as 3.5 ns (FWHM), corresponding to a peak power of >10kW, have been generated, and the maximum slope efficiency with respect to the absorbed pump power was 13%. Using a bulk diffraction grating in the Littrow configuration to provide wavelength-selective feedback, we tuned the passively Q -switched fiber laser over 31 nm from 1532 to 1563 nm. The prospects for further improvement in performance are discussed.

900-nm Nd:Ti:LiNbO(3) waveguide laser.

We report what is to our knowledge the first laser operation of Nd(3+) -doped LiNbO(3) near 900 nm. An absorbed power threshold of 26 mW was obtained when the device was pumped at 814 nm. The design of the waveguide geometry to favor laser operation at this wavelength is demonstrated.

Second-harmonic generation in a direct-bonded periodically poled LiNbO(3) buried waveguide.

We report the fabrication of a 12-mum -thick periodically poled LiNbO(3) planar waveguide buried in LiTaO(3) by direct bonding of precision-polished surfaces. Frequency doubling of the 1064-nm output of a cw diode-pumped Nd:YAG laser was performed in a 5.5-mm-long device with a 6.50-mum -period grating at an elevated temperature of 174 degrees C. The resultant green second-harmonic output exhibited fundamental-spatial-mode characteristics at a 4.3%W(-1) conversion efficiency.

Ion-exchanged tapered-waveguide laser in neodymium-doped BK7 glass.

We report what is to our knowledge the first operation of a planar dielectric tapered-waveguide laser. The waveguide laser is fabricated by potassium-ion exchange in Nd(3+) -doped BK7 glass and consists of a single-mode channel waveguide of a few micrometers' width followed by a linear taper up to a broad region with a width of ~180microm . A slope efficiency of 42% is found both in the tapers and in standard channel waveguides fabricated upon the same substrate, indicating that the tapers and the channels have similar internal losses; hence the low-loss nature of the tapered beam expansion. The output from either end of the tapered structure is found to be nearly diffraction limited.

Linkage analysis of systemic lupus erythematosus induced in diabetes-prone nonobese diabetic mice by Mycobacterium bovis.

Systemic lupus erythematosus induced by Mycobacterium bovis in diabetes-prone nonobese diabetic mice was mapped in a backcross to the BALB/c strain. The subphenotypes-hemolytic anemia, antinuclear autoantibodies, and glomerular immune complex deposition-did not cosegregate, and linkage analysis for each trait was performed independently. Hemolytic anemia mapped to two loci: Bah1 at the MHC on chromosome 17 and Bah2 on distal chromosome 16. Antinuclear autoantibodies mapped to three loci: Bana1 at the MHC on chromosome 17, Bana2 on chromosome 10, and Bana3 on distal chromosome 1. Glomerular immune complex deposition did not show significant linkage to any genomic region. Mapping of autoantibodies (Coombs' or antinuclear autoantibodies) identified two loci: Babs1 at the MHC and Babs2 on distal chromosome 1. It has previously been reported that genes conferring susceptibility to different autoimmune diseases map nonrandomly to defined regions of the genome. One possible explanation for this clustering is that some alleles at loci within these regions confer susceptibility to multiple autoimmune diseases-the "common gene" hypothesis. With the exception of the H2, this study failed to provide direct support for the common gene hypothesis, because the loci identified as conferring susceptibility to systemic lupus erythematosus did not colocalize with those previously implicated in diabetes. However, three of the four regions identified had been previously implicated in other autoimmune diseases.

Channel waveguide laser at 1 microm in Yb-indiffused LiNbO(3).

We report laser action in a Ti-diffused LiNbO(3) waveguide doped with trivalent Yb ions by thermal indiffusion. Lasing was observed at 1008, 1030, and 1060 nm with thresholds as low as 15-mW launched pump power. We reduced photorefractivity, which initially permitted only intermittent lasing, by annealing the sample in wet O(2). The annealed sample lased continuously in a cavity formed by high-ref lectivity mirrors; however, with a 7% output coupler the output power exhibited instabilities. The greatest value of the output power observed under these conditions was consistent with a slope efficiency of ~16% with respect to absorbed power.

Ion-implanted Nd:MgO:LiNbO(3) planar waveguide laser.

Laser oscillation in an ion-implanted planar Nd:MgO:LiNbO(3) waveguide is demonstrated for the first time to our knowledge. Details of the waveguide structure, spectroscopic properties, photorefractive effects, and laser performance are given. A simple calculation of the absorbed power threshold gives ~8 mW, in fair agreement with the experimental value of ~17 mW.