Detalhe da pesquisa
1.
SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants.
J Med Virol
; 89(9): 1620-1628, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28303593
2.
Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum.
Bioorg Med Chem Lett
; 24(5): 1274-9, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24507921
3.
The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.
Bioorg Med Chem Lett
; 21(1): 48-51, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21146984
4.
Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
J Am Chem Soc
; 132(38): 13320-31, 2010 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20822105
5.
Penicillin sulfone inhibitors of class D beta-lactamases.
Antimicrob Agents Chemother
; 54(4): 1414-24, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20086146
6.
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice.
Front Immunol
; 11: 592333, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33365029
7.
Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks.
PLoS One
; 12(1): e0169631, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28056062
8.
Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B.
PLoS One
; 11(8): e0161313, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27552102
9.
Structures of SHV-1 ß-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation.
PLoS One
; 7(11): e49035, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23145056
10.
The importance of the trans-enamine intermediate as a ß-lactamase inhibition strategy probed in inhibitor-resistant SHV ß-lactamase variants.
ChemMedChem
; 7(6): 1002-8, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22438274
11.
Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence.
Biochemistry
; 47(13): 4094-101, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18324783
12.
Efficient inhibition of class A and class D beta-lactamases by Michaelis complexes.
J Biol Chem
; 282(30): 21588-91, 2007 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17561511
13.
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase.
Biochemistry
; 46(31): 8980-7, 2007 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-17630699
14.
Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.
J Am Chem Soc
; 128(40): 13235-42, 2006 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17017804