High-Performance Flexible Piezoelectric Nanogenerator Based on Specific 3D Nano BCZT@Ag Hetero-Structure Design for the Application of Self-Powered Wireless Sensor System.

With the popularity of portable and miniaturized electronic devices in people's live, flexible piezoelectric nanogenerators (PENG) have become a research hotspot for harvesting energy from the living environment to power small-scale electronic equipment and systems because of its stability. For further enhancing output performance of PENG, chemical modification and structural design for piezoelectric fillers are effective ways. Thus, the 3D porous hetero-structure fillers of BCZT@Ag are prepared by freeze-drying method and subsequent chemical seeding reduction. The silicone rubber as matrix is filled into the micro-voids of fillers to prepare specialized composite. The charge transport mechanism and stress transfer efficiency in PENG can be effectively improved through specialized design which is proven by experimental results and multi-physics simulations. The improved PENG exhibit a significantly enhanced output of 38.6 V and 5.85 µA, which is 3.3 and 3.5 times higher than those of PENG without specific design. The prepared PENG can effectively harvest biomechanical energy through walk and joint bending of human body. Moreover, the PENG can be used as a trigger to remotely control wireless collision alarm system, which can acquire rapid response and shows great potential application in Internet of Things.

Psychological problems and quality of life of patients with oral mucosal diseases: a preliminary study in Chinese population.

BACKGROUND: Psychological problems might play important roles in oral mucosal diseases such as recurrent aphthous ulcers (RAU), oral lichen planus (OLP), burning mouth syndrome (BMS), but the relevance to patients' quality of life remained controversial. The aim of this study was to investigate the psychological problems and oral health-related quality of life in patients with RAU, OLP, and BMS in China, to assess the relationship between psychological problems and quality of life. METHOD: Thirty-nine RAU patients, 45 OLP patients, 15 BMS patients and 45 healthy controls were enrolled in the study. Hospital Anxiety and Depression Scale (HADS) were chosen to analyze the patients' psychological problems. Oral Health Impact Profile (OHIP-14) was used to measure the OHRQoL. The scores of HADS and OHIP-14 were used to analyze the relationship between psychological problems and the quality of life of oral mucosa patients. RESULTS: Each of OHIP-14 scores and HADS scores in RAU, OLP, BMS was higher than the control group, and there was significant difference in the patients groups with the control cases(P < 0.05). OHIP-14 score of RAU was the highest in three patient groups. Its OHRQoL was lowest in the three groups, which had statistical significance (P < 0.05). Positive correlations existed between the psychological problems and the quality of life of the three patient groups (rs > 0, P < 0.05), except for the depression of the BMS group (rs = 0.168, P = 0.395). CONCLUSION: Patients with oral mucosal diseases such as RAU, OLP, and BMS had higher levels of anxiety, depression, and lower quality of life. The patient's psychological problems were related to their quality of life, suggesting that the psychological state of patients with oral mucosal disease need more attention.

Cardiotoxicity and Mechanism of Particulate Matter 2.5 (PM2.5) Exposure in Offspring Rats During Pregnancy.

BACKGROUND The aim of this study was to investigate the cardiotoxicity and mechanism of particulate matter 2.5 (PM2.5) exposure on offspring rats during pregnancy. MATERIAL AND METHODS Wistar rats were used to establish a PM2.5 exposure animal model during pregnancy, and they were divided into a control group, a low-dose group, a middle-dose group, and a high-dose group according to PM2.5 exposure dose. The pathological changes of heart tissue, the rate of myocardial cell apoptosis, the levels of LDH, AST, and CM-KB in serum, and the difference in mitochondrial fusion genes (OPA1 and Mfn1) and mitochondrial genes (Drp1 and Fis1) were compared among groups. RESULTS The arrangement of myocardial fibers in offspring mice of PM2.5 exposure groups became disordered, the shape of some cardiomyocytes became irregular, and some staining darker nuclei appeared. The apoptotic rates of myocardium in offspring rats exposed to PM2.5 were (12.61±0.93)% in the low-dose group, (25.14±1.53)% in the middle-dose group, and (30.13±1.50)% in the high-dose group, which were all significantly higher than in the control group (9.12±0.80)% (P<0.05). The levels of LDH, AST, and CM-KB and the expression of OPA1, Mfn1, Drp1, and Fis1 in offspring mice of PM2.5 exposure groups increased with the increase of PM2.5 exposure dose, and were significantly higher than that of the control group (P<0.05). CONCLUSIONS The mitochondria of the offspring mice were damaged due to the abnormal expression of mitochondrial fusion/splicing gene by PM2.5 exposure during pregnancy, and the hearts of offspring mice were damaged due to damaged mitochondria.

A femtomolar level and highly selective 17ß-estradiol photoelectrochemical aptasensor applied in environmental water samples analysis.

Driven by the urgent demand of determining low level of 17ß-estradiol (E2) present in environment, a novel and ultrasensitive photoelectrochemical (PEC) sensing platform based on anti-E2 aptamer as the biorecognition element was developed onto CdSe nanoparticles-modified TiO2 nanotube arrays. The designed PEC aptasensor exhibits excellent performances in determination of E2 with a wide linear range of 0.05-15 pM. The detection limit of 33 fM is lower than the previous reports. The aptasensor manifests outstanding selectivity to E2 while used to detect seven other endocrine disrupting compounds that have similar structure or coexist with E2. The superior sensing behavior toward E2 can be attributed to the appropriate PEC sensing interface resulting from the preponderant tubular microstructure and excellent photoelectrical activity, the large packing density of aptamer on the sensing interface, as well as the high affinity of the aptamer to E2. The PEC aptasensor was applied successfully to determine E2 in environmental water samples without complicate sample pretreatments, and the analytical results showed good agreement with that determined by HPLC. Thus, a simple and rapid PEC technique for detection low level of E2 was established, having promising potential in monitoring environmental water pollution.

Fabrication of a novel and simple microcystin-LR photoelectrochemical sensor with high sensitivity and selectivity.

Microcystin-LR (MC-LR), an inert electrochemical species, is difficult to be detected by a simple and direct electrochemical method. In the present work, a novel photoelectrochemical sensor is developed on highly ordered and vertically aligned TiO(2) nanotubes (TiO(2) NTs) with convenient surface modification of molecularly imprinted polymer (MIP) (denoted as MIP@TiO(2) NTs) for highly sensitive and selective determination of MC-LR in solutions. Molecularly imprinted polypyrrole (PPy) of MC-LR is chosen as the recognition element. The designed MIP@TiO(2) NTs photoelectrochemical sensor presents excellent applicability in MC-LR determination, with linear range from 0.5 to 100 µg L(-1) and limit of detection of 0.1 µg L(-1). Moreover, the sensor exhibits outstanding selectivity while used in coexisting systems containing 2,4-dichorophenoxyacetic acid, atrazine, paraquat, or monosultap with high concentration, 100 times that of MC-LR. The sensor presents good photoelectric conversion efficiency and detection sensitivity, as well as broad linear detection range, mainly because of the high specific surface area and photoelectric activity of TiO(2) NTs and the π bond delocalized electron system of PPy that promotes the separation of electron-holes. The prominent selectivity is from the MIP by forming multiple hydrogen bonds between PPy and MC-LR. Mechanisms for photoelectrochemical analysis and selective recognition are also discussed.

Structure design and wireless transmission application of hybrid nanogenerators for swinging mechanical energy and solar energy harvesting.

With the rapid development of the Internet of Things, the maintenance-free and reliable power supply of widely distributed sensors is still a huge challenge, especially in wireless areas. Wireless power transmission is expected to alleviate the issue that the sensors must be connected by wire to power supply devices. Herein, a novel hybrid nanogenerator combining a triboelectric nanogenerator (TENG) and photovoltaic cell has been demonstrated, which can realize the simultaneous collection and wireless power transmission of swinging mechanical energy and solar energy. The wireless power transmission system based on the hybrid nanogenerator can be actualized through series connection of the TENG and photovoltaic cell with the aid of a specifically designed mechanical switch, enabling the system to generate DC pulses that favor transmitting energies through LC oscillation and a coupled receiver coil. At the receiver coil end, the open-circuit voltage (Voc) of the hybrid nanogenerator can reach 80 V, showing excellent wireless output performance and the rationality of the wireless power transmission circuit. Moreover, the hybrid nanogenerator can wirelessly power a commercial temperature-humidity meter, which indicates the remarkable potential of improving the layout flexibility of sensor nodes. This work successfully realizes the wireless power transmission of hybrid nanogenerator-harvested swinging mechanical energy and solar energy by a simple and feasible circuit design, which can enrich the form of micro/nano energy adapted to wireless energy transmission.

Highly efficient photoelectrochemical removal of atrazine and the mechanism investigation: Bias potential effect and reactive species.

In this work, efficient photoelectrochemical (PEC) removal of atrazine, one of the most widely used chemical herbicides in the world, was obtained by adjusting the bias potential applied on the photo-anode, and the optimal atrazine removal efficiency reached 96.8% at the potential of 0.2 V vs. SCE in 2 h with the reaction rate constant of 1.72 h-1. The results indicated at the optimal potential, the separation efficiency of photo-generated holes and electrons was the highest with the lowest electron transfer resistance. Mechanism investigation revealed that superoxide radicals, hydroxyl radicals and holes all contributed to atrazine degradation, and the bias potential on the photo-anode could influence atrazine removal efficiency by changing the generation amount and distribution of the reactive oxygen species (ROS). It was presumed the nucleophilicity of superoxide radical played an important role in atrazine dechlorination, leading to the enhanced removal efficiency. However, the bias potential did not show obvious influence on the degradation intermediates of atrazine in the PEC system compared with that in photocatalytic oxidation, since it was actually an electro-assisted photocatalytic process in the potential range investigated. The work will provide fundamental basis for establishing efficient PEC system for pollutant remediation experimentally and theoretically.

Mechanism investigation on the enhanced photocatalytic oxidation of nonylphenol on hydrophobic TiO2 nanotubes.

Enhanced and selective photocatalytic oxidation of nonylphenol (NP), a typical hydrophobic endocrine disrupting chemicals (EDCs), was realized on hydrophobic titanium dioxide nanotubes (H-TiO2NTs), which was fabricated by an electrochemical anodization method, followed by grafting of perfluorooctyl groups. The water contact angle of catalyst surface changed from 21.1° to 128.4° after hydrophobic modification. H-TiO2NTs showed excellent photocatalytic oxidation performance for NP, that it was completely converted in 40 min under irradiation, which was improved for about 17% compared with the hydrophilic TiO2NTs. The enhanced photocatalytic performance of H-TiO2NTs was attributed to the stronger adsorption ability toward NP identified by ATR-FTIR, with an initial adsorption rate of 4 times as higher as that of bare TiO2NTs. Meanwhile, the hydrophobic surface of H-TiO2NTs was beneficial for generation of more hydroxyl radicals. The apparent rate constant of hydroxyl radicals' generation on H-TiO2NTs, which was the main oxidizing species, could reach 1.83 times that of the hydrophilic TiO2NTs. Both the two factors contributed to the successful competition of NP against the coexistent hydrophilic contaminates in the adsorption and oxidation on the catalyst surface, leading to the selective removal of NP in mixed systems finally.

Identification of CHRNB4 as a Diagnostic/Prognostic Indicator and Therapeutic Target in Human Esophageal Squamous Cell Carcinoma.

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors and there is a lack of biomarkers for ESCC diagnosis and prognosis. Family subunits of cholinergic nicotinic receptor genes (CHRNs) are involved in smoking behavior and tumor cell proliferation. Previous researches have shown similar molecular features and pathogenic mechanisms among ESCC, head and neck squamous cell carcinoma (HNSC), and lung squamous cell carcinoma (LUSC). Using edgeR, three mutual differentially expressed genes of CHRNs were found to be significantly upregulated at the mRNA level in ESCC, LUSC, and HNSC compared to matched normal tissues. Kaplan-Meier survival analysis showed that high expression of CHRNB4 was associated with unfavorable prognosis in ESCC and HNSC. The specific expression analysis revealed that CHRNB4 is highly expressed selectively in squamous cell carcinomas compared to adenocarcinoma. Cox proportional hazards regression analysis was performed to find that just the single gene CHRNB4 has enough independent prognostic ability, with the area under curve surpassing the tumor-node-metastasis (TNM) staging-based model, the most commonly used model in clinical application in ESCC. In addition, an effective prognostic nomogram was established combining the TNM stage, gender of patients, and expression of CHRNB4 for ESCC patients, revealing an excellent prognostic ability when compared to the model of CHRNB4 alone or TNM. Gene Set Enrichment Analysis results suggested that the expression of CHRNB4 was associated with cancer-related pathways, such as the mTOR pathway. Cell Counting Kit-8, cloning formation assay, and western blot proved that CHRNB4 knockdown can inhibit the proliferation of ESCC cells via the Akt/mTOR and ERK1/2/mTOR pathways, which might facilitate the prolonged survival of patients. Furthermore, we conducted structure-based molecular docking, and potential modulators against CHRNB4 were screened from FDA approved drugs. These findings suggested that CHRNB4 specifically expressed in SCCs, and may serve as a promising biomarker for diagnosis and prognosis prediction, and it can even become a therapeutic target of ESCC patients.

Design of a simple and novel photoelectrochemical aptasensor for detection of 3,3',4,4'-tetrachlorobiphenyl.

In view of the urgent need of determining polychlorinated biphenyls in the environment, we developed a highly sensitive and selective photoelectrochemical (PEC) aptasensor for determination of 3,3',4,4'-tetrachlorobiphenyl (PCB77) by immobilizing aptamer on N-doped TiO2 nanotubes (N-doped TiO2 NTs). To improve analytical performance of the PEC sensor, the complementary DNA functionalized CdS quantum dots (DNA-CdS QDs) were introduced onto N-doped TiO2 NTs by hybridization. In addition of PCB77, owing to high affinity of aptamer to PCB77, PCB77-aptamer complexes were formed by being bound of PCB77 whilst DNA-CdS QDs were released from the sensing surface. The complexes with poor conductivity hindered the interfacial electron transfer, leading to the photocurrent decrease. The more important is the release of DNA-CdS QDs enhanced the photocurrent decrease, playing the role of signal amplification. The photocurrent change was utilized to detect PCB77 quantitatively. The PEC aptasensor exhibited excellent analytical performance for detection of PCB77 with wide linear range of 0.1-100 ng/L and a low detection limit of 0.1 ng/L. It manifested outstanding selectivity for PCB77 in control experiments by employing six interferents which had similar structure or coexisted with PCB77. Besides, the PEC aptasensor was used to detect the content of PBC77 in the environment.

Enhanced Photoelectrocatalytic Reduction and Removal of Atrazine: Effect of Co-Catalyst and Cathode Potential.

Photoelectrocatalytic (PEC) reduction and removal of atrazine, one typical endocrine disruptor chemical, was achieved on Pd quantum dots modified TiO2 nanotubes (PdQDs@TiO2NTs) under regulating potentials. Compared with that on TiO2NTs, the PEC reduction efficiency of atrazine on PdQDs@TiO2NTs significantly increased, mainly attributed to the reduced electron transfer resistance, longer lifetime of the photogenerated electrons and the faster electron injection from the catalyst to atrazine in the solution. Meanwhile, PdQDs could also function as cocatalyst so that the electrocatalytic activity of PdQDs@TiO2NTs was evidently improved. Moreover, the investigation indicated that the applied potential not only played important role in accelerating the separation of photogenerated electrons and holes, but also with the increment of the cathodic potential, the PEC reduction mechanism of atrazine underwent the variation of electro-assisted photocatalysis, synergetic photoelectro-catalysis, and photoassisted electro-catalysis. A highest atrazine PEC reduction efficiency was achieved as 99.5% on PdQDs@TiO2NTs in about 5 h under the potential of -1.3 V vs. SCE, whereas the highest synergetic effect of photo- and electro- catalysis was achieved at a lower potential of -0.9 V vs. SCE.

The Synthesis and Biological Function of a Novel Sandwich-Type Complex Based on {SbW9 } and Flexible bpp Ligand.

A novel sandwich-type complex [Na(H2 O)4 ][{Na3 (H2 O)5 }{Mn3 (bpp)3 } (SbW9 O33 )2 }]·8H3 O (MnSbW-bpp) (bpp = 1,3-bis(4-pyridyl) propane) is synthesized and characterized by elemental analysis, IR, thermogravimetric analysis, and single-crystal X-ray diffraction. The MnSbW-bpp compound is the first sandwich case bridged by a flexible ligand. Its biological function of MnSbW-bpp in antitumor activity is also determined in vitro and in vivo. The inhibitory proliferation and induction of apoptosis are performed by flow cytometry assay, S180 (sarcoma) tumor xenograft in ICR mice, the color Doppler ultrasound monitor, and TdT-mediated dUTP-biotin nick end labeling assay. The results show that the novel compound-MnSbW-bpp-is synthesized and identified by its physical and chemical characteristics, such as the fluorescent and paramagnetic activities. MnSbW-bpp indicates a potency inhibition of human cancer lines, such as SGC-7901, HT-29, HepG2, Hela, U2OS, SaoS2, and HMC cells. MnSbW-bpp also inhibits the growth of tumor xenograft in mice, induced cell apoptosis, and released cytochrome c in vivo and in vitro. Thus, MnSbW-bpp, as a new compound, possesses the potent inhibition of cancer cells, which indicates that the MnSbW-bpp has potential merit for the further evaluation of a novel antitumor agent.

A highly sensitive and selective aptamer-based colorimetric sensor for the rapid detection of PCB 77.

A highly sensitive, specific and simple colorimetric sensor based on aptamer was established for the detection of polychlorinated biphenyls (PCB 77). The use of unmodified gold nanoparticles as a colorimetric probe for aptamer sensors enabled the highly sensitive and selective detection of polychlorinated biphenyls (PCB 77). A linear range of 0.5nM to 900nM was obtained for the colorimetric assay with a minimum detection limit of 0.05nM. In addition, by the methods of circular dichroism, UV and naked eyes, we found that the 35 base fragments retained after cutting 5 bases from the 5 'end of aptamer plays the most significant role in the PCB 77 specific recognition process. We found a novel way to truncated nucleotides to optimize the detection of PCB 77, and the selected nucleotides also could achieve high affinity with PCB 77. At the same time, the efficient detection of the PCB 77 by our colorimetric sensor in the complex environmental water samples was realized, which shows a good application prospect.

Preparation and Characterization of Acid Resistant Double Cross-Linked Hydrogel for Potential Biomedical Applications.

A novel biocompatible polysaccharide-based hydrogel with double cross-linked network (DN) was designed and developed by combining dynamic imine bond and Diels-Alder (DA) click reaction. Our results showed that the dynamic covalent imine bond led to the hydrogel's self-healing property, while the DA reaction gave the superior thermodynamic property and acid resistance to the hydrogel. At the same time, the double cross-linked structure improved the mechanical properties of hydrogels. Moreover, the DN hydrogel had good biocompatibility, as confirmed by three-dimensional cell encapsulation. On the basis of these excellent properties, the present prepared hydrogel holds great potential in the field of biomaterials.

Cathodic photoelectrochemical detection of PCB101 in environmental samples with high sensitivity and selectivity.

A novel cathodic photoelectrochemical (PEC) sensing method was developed for fast and convenient detection of PCB101 taking advantages of the excellent PEC reducibility of Pd quantum dots (QDs) modified molecularly imprinted TiO2 nanorods (NRs). Attributed to the efficient PEC reduction of PCB101 on the cathode surface, sensitive cathodic photocurrent would be produced with increasing PCB101 concentration under a negative bias potential, giving a low PCB101 detection limit of 5×10-14molL-1. Meanwhile, molecular imprinting (MI) technique was integrated by in situ introduction of MI sites on the surface of TiO2 NRs, so that highly specific adsorption and reduction of PCB101 congener could be obtained. The results indicated that the PEC sensor presented excellent selectivity toward PCB101 with the coexistance of 100-fold excess of other pollutants including the PCBs congeners, other aromatic pollutants, and heavy metal ions. The cathodic PEC sensor was sucessfully applied in determination of PCB101 in real water and soil samples, and the results had good consistency with that obtained by the traditional GC-MS. This work provides a new concept and research basis for fabricating cathodic PEC sensor for the environmental pollutants with specific structures that were easily reduced.

IMM-H007, a new therapeutic candidate for nonalcoholic fatty liver disease, improves hepatic steatosis in hamsters fed a high-fat diet.

Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in humans, is characterized by the accumulation of triacylglycerols (TGs) in hepatocytes. We tested whether 2',3',5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine (IMM-H007) can eliminate hepatic steatosis in hamsters fed a high-fat diet (HFD), as a model of NAFLD. Compared with HFD-only controls, IMM-H007 treatment significantly lowered serum levels of TG, total cholesterol, and free fatty acids (FFAs) in hamsters fed the HFD, with a prominent decrease in levels of serum transaminases and fasting insulin, without affecting fasting glucose levels. Moreover, 1H-MRI and histopathological analyses revealed that hepatic lipid accumulation and fibrosis were improved by IMM-H007 treatment. These changes were accompanied by improvement of insulin resistance and oxidative stress, and attenuation of inflammation. IMM-H007 reduced expression of proteins involved in uptake of hepatic fatty acids and lipogenesis, and increased very low density lipoprotein secretion and expression of proteins responsible for fatty acid oxidation and autophagy. In studies in vivo, IMM-H007 inhibited fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulated fatty acid oxidation, autophagy, and export of hepatic lipids. These data suggest that IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. Thus, IMM-H007 has therapeutic potential for NAFLD.

Prognostic genes of breast cancer revealed by gene co-expression network analysis.

The aim of the present study was to identify genes that may serve as markers for breast cancer prognosis by constructing a gene co-expression network and mining modules associated with survival. Two gene expression datasets of breast cancer were downloaded from ArrayExpress and genes from these datasets with a coefficient of variation >0.5 were selected and underwent functional enrichment analysis with the Database for Annotation, Visualization and Integration Discovery. Gene co-expression networks were constructed with the WGCNA package in R. Modules were identified from the network via cluster analysis. Cox regression was conducted to analyze survival rates. A total of 2,669 genes were selected, and functional enrichment analysis of them revealed that they were mainly associated with the immune response, cell proliferation, cell differentiation and cell adhesion. Seven modules were identified from the gene co-expression network, one of which was found to be significantly associated with patient survival time. Expression status of 144 genes from this module was used to cluster patient samples into two groups, with a significant difference in survival time revealed between these groups. These genes were involved in the cell cycle and tumor protein p53 signaling pathway. The top 10 hub genes were identified in the module. The findings of the present study could advance the understanding of the molecular pathogenesis of breast cancer.

Double-Layer 3D Macro-Mesoporous Metal Oxide Modified Boron-Doped Diamond with Enhanced Photoelectrochemical Performance.

In this work, a TiO2/Sb-doped SnO2 electrode was prepared on the boron-doped diamond (BDD) substrate with double-layer three-dimensional macro-mesoporous (DL3DOM-m) structure, using the polystyrene sphere (PS) vertical deposition method. The as-prepared DL3DOM-m TiO2/SnO2/BDD was employed for organic contaminant removal, showing excellent photoelectrocatalytic performance. SEM, XRD and XPS indicated that DL3DOM-m electrode possessed a 3D macroporous layered framework with uniform pore size (about 400 nm), nanosized particles (4.5-5.8 nm), and high electroactive surface area (3-fold more than that of BDD). SA-XRD indicated the backbone of DL3DOM-m electrode had mesoporous structure. It was found that the as-prepared electrode exhibited remarkable electrocatalytic activity, high photocurrent and outstanding absorption capability (91.0 µg cm-2). Furthermore, bisphenol A (BPA) was completely decomposed after 3 h of reaction applying DL3DOM-m electrode as photoanode, and that on BDD was only 58.9%. It indicated that the modified electrode had great potential to be used in practical water treatment with high photoelectrochemical performance.

In situ grown, self-supported iron-cobalt-nickel alloy amorphous oxide nanosheets with low overpotential toward water oxidation.

Electrocatalytic water oxidation by in situ grown iron-cobalt-nickel ternary alloy amorphous oxides is reported. This catalytic material was prepared by simple anodization of an alloy plate followed by low-temperature annealing, which shows superior electrocatalytic activity toward oxygen evolution reaction with an overpotential of only 170 mV and a low Tafel slope.

A highly selective and picomolar level photoelectrochemical sensor for PCB 101 detection in environmental water samples.

A highly selective and sensitive photoelectrochemical (PEC) sensor was fabricated for fast and convenient detection of PCB 101 in environmental water samples with a low detection limit of 1.0×10(-14)molL(-1) based on single crystalline TiO2 nanorods (NRs). By integration with molecular imprinting (MI) technique, the PEC sensor's selectivity towards PCB 101 was significantly improved, so that the interference caused by 100-fold excess of PCB 126 and PCB 77 which had similar structure with PCB 101 was below 37%, not to mention other coexisted pollutants. This high selectivity could be attributed to the high-quality expression of the molecular imprinting sites on the rigid and smooth surface of single crystalline TiO2 NRs on which PCB 101 could be selectively and preferentially adsorbed. The oriented and multiple halogen bonds formed between PCB 101 and the molecular imprinting sites played a critical role in improving the recognition ability of the PEC sensor. Meanwhile, the one dimensional nanorods structure of TiO2 was beneficial for the efficient separation of photogenerated electrons and holes, leading to enhanced photocurrent response and further improving the sensitivity of the PEC sensor.