RESUMO
To examine whether patterns, such as the timings of onset or recovery from sleep disturbance, are associated with later developmental problems, including autism spectrum disorder (ASD). Mothers participating in the Japan Environment and Children's Study with a child aged 3 years were included in the analyses. Children were assessed for short sleep and frequent awakenings at 1 month, 6 months, and 1 year of age. Developmental problems were evaluated at 3 years of age based on ASD diagnosis and developmental delay, using the Japanese translation of the Ages and Stages Questionnaire (ASQ) 3rd edition. Sleep disturbance patterns were classified by onset age, and developmental problem risks were examined based on onset/recovery ages. Among 63,418 mother-infant dyads, 0.4% of infants were later diagnosed with ASD, and 14.4% had abnormal scores on any ASQ domains. The later the onset of short sleep, the lower the risk of abnormal ASQ scores (RR of short sleep onset at 1 year: 1.41; 6 months: 1.52; 1 month: 1.57). The earlier the infants recovered from short sleep persistence, the lower the risk of developmental delay (RR of remittance of sleep problems identified at 1 month by 6 months: 1.07; 1 year: 1.31; not before 1 year: 1.57). Although not all patterns were significant, later short sleep onset and earlier recovery were associated with lower ASD risk. These findings may have significant implications for future interventions in infant development.
Assuntos
Transtorno do Espectro Autista , Deficiências do Desenvolvimento , Transtornos do Sono-Vigília , Humanos , Lactente , Japão/epidemiologia , Feminino , Masculino , Deficiências do Desenvolvimento/epidemiologia , Deficiências do Desenvolvimento/etiologia , Pré-Escolar , Transtornos do Sono-Vigília/epidemiologia , Transtorno do Espectro Autista/epidemiologia , Inquéritos e Questionários , Fatores de Risco , Sono/fisiologiaAssuntos
Heparina/administração & dosagem , Trabalho de Parto Induzido/métodos , Complicações na Gravidez , Embolia Pulmonar , Esplenectomia , Trombose Venosa , Talassemia beta , Adulto , Anticoagulantes/administração & dosagem , Testes de Coagulação Sanguínea , Transfusão de Sangue/métodos , Feminino , Idade Gestacional , Humanos , Extremidade Inferior/irrigação sanguínea , Pulmão/diagnóstico por imagem , Gravidez , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/etiologia , Complicações na Gravidez/fisiopatologia , Complicações na Gravidez/terapia , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/etiologia , Embolia Pulmonar/fisiopatologia , Embolia Pulmonar/terapia , Intensificação de Imagem Radiográfica/métodos , Esplenectomia/efeitos adversos , Esplenectomia/métodos , Resultado do Tratamento , Ultrassonografia Doppler Dupla/métodos , Trombose Venosa/diagnóstico , Trombose Venosa/etiologia , Trombose Venosa/fisiopatologia , Trombose Venosa/terapia , Talassemia beta/complicações , Talassemia beta/diagnóstico , Talassemia beta/cirurgiaRESUMO
Post-transplant lymphoproliferative disorder (PTLD) refers to a group of diseases, characterized by abnormal proliferation of lymphocytes, that develop after organ transplantation. PTLD is associated with poor prognosis, and has become a major problem for transplant patients. In this report, we described a case of malignant lymphoma of the cervix in a bicollis uterus considered to be a PTLD in a patient after renal transplantation. The incidence of this disease is expected to increase as the survival rate of transplant patients improves. Hence, it is very important for gynecological oncologists to consider the presence of PTLD when examining such patients.