Detalhe da pesquisa
1.
Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.
Mol Cell
; 80(2): 279-295.e8, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33065020
2.
Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1.
PLoS Comput Biol
; 17(9): e1008513, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34529665
3.
Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models.
Breast Cancer Res
; 23(1): 82, 2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34344433
4.
Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer.
PLoS Comput Biol
; 14(6): e1006192, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29920512
5.
ELECANS--an integrated model development environment for multiscale cancer systems biology.
Bioinformatics
; 29(7): 957-9, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23390137
6.
Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer.
NPJ Precis Oncol
; 8(1): 20, 2024 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38273040
7.
Integrative modeling and analysis of signaling crosstalk reveal molecular switches coordinating Yes-associated protein transcriptional activities.
iScience
; 27(3): 109031, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38380257
8.
Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically 'actionable' signalling axis in triple negative breast cancer.
bioRxiv
; 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38405732
9.
A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network.
J Cell Sci
; 124(Pt 1): 82-90, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21172821
10.
SynDISCO: A Mechanistic Modeling-Based Framework for Predictive Prioritization of Synergistic Drug Combinations Targeting Cell Signalling Networks.
Methods Mol Biol
; 2634: 357-381, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37074588
11.
A Boolean-based machine learning framework identifies predictive biomarkers of HSP90-targeted therapy response in prostate cancer.
Front Mol Biosci
; 10: 1094321, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36743211
12.
The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
Oncogene
; 42(11): 833-847, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36693952
13.
Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression.
iScience
; 24(2): 102118, 2021 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33659881
14.
Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts.
Biophys J
; 99(3): 716-25, 2010 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20682248
15.
System-level investigation into the regulatory mechanism of the calcineurin/NFAT signaling pathway.
Cell Signal
; 20(6): 1117-24, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18325738
16.
Coupled feedback regulation of nuclear factor of activated T-cells (NFAT) modulates activation-induced cell death of T cells.
Sci Rep
; 9(1): 10637, 2019 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31337782
17.
Global redox proteome and phosphoproteome analysis reveals redox switch in Akt.
Nat Commun
; 10(1): 5486, 2019 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31792197
18.
Cardiac systems biology and parameter sensitivity analysis: intracellular Ca2+ regulatory mechanisms in mouse ventricular myocytes.
Adv Biochem Eng Biotechnol
; 110: 25-45, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18437298
19.
Dissecting Cell-Fate Determination Through Integrated Mathematical Modeling of the ERK/MAPK Signaling Pathway.
Methods Mol Biol
; 1487: 409-432, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27924583
20.
Switching feedback mechanisms realize the dual role of MCIP in the regulation of calcineurin activity.
FEBS Lett
; 580(25): 5965-73, 2006 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17046757