Detalhe da pesquisa
1.
Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney.
J Am Soc Nephrol
; 32(8): 1898-1912, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33958489
2.
Sensitivity of pituitary gonadotropes to hyperglycemia leads to epigenetic aberrations and reduced follicle-stimulating hormone levels.
FASEB J
; 33(1): 1020-1032, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30074825
3.
Quantitative flux analysis reveals folate-dependent NADPH production.
Nature
; 510(7504): 298-302, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24805240
4.
Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis.
J Am Soc Nephrol
; 30(3): 381-392, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30728179
5.
Inferring cancer dependencies on metabolic genes from large-scale genetic screens.
BMC Biol
; 17(1): 37, 2019 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31039782
6.
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.
Nature
; 498(7452): 109-12, 2013 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23685455
7.
Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements.
Proc Natl Acad Sci U S A
; 113(12): 3401-6, 2016 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951675
8.
Temporal fluxomics reveals oscillations in TCA cycle flux throughout the mammalian cell cycle.
Mol Syst Biol
; 13(11): 953, 2017 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29109155
9.
Metabolite concentrations, fluxes and free energies imply efficient enzyme usage.
Nat Chem Biol
; 12(7): 482-9, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27159581
10.
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature
; 477(7363): 225-8, 2011 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21849978
11.
Reconstruction of Arabidopsis metabolic network models accounting for subcellular compartmentalization and tissue-specificity.
Proc Natl Acad Sci U S A
; 109(1): 339-44, 2012 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22184215
12.
Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches.
BMC Biol
; 17(1): 51, 2019 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31272436
13.
Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux.
J Biol Chem
; 288(43): 31363-9, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24030823
14.
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells.
BMC Genomics
; 15: 158, 2014 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24568598
15.
Quantitation of cellular metabolic fluxes of methionine.
Anal Chem
; 86(3): 1583-91, 2014 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24397525
16.
An integrated computational approach for metabolic flux analysis coupled with inference of tandem-MS collisional fragments.
Bioinformatics
; 29(23): 3045-52, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24123514
17.
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.
Mol Syst Biol
; 9: 712, 2013 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24301801
18.
Prediction of microbial growth rate versus biomass yield by a metabolic network with kinetic parameters.
PLoS Comput Biol
; 8(7): e1002575, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22792053
19.
Inferring mitochondrial and cytosolic metabolism by coupling isotope tracing and deconvolution.
Nat Commun
; 14(1): 7525, 2023 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37980339
20.
Predicting selective drug targets in cancer through metabolic networks.
Mol Syst Biol
; 7: 501, 2011 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21694718