Detalhe da pesquisa
1.
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.
Proc Natl Acad Sci U S A
; 109(21): 8298-303, 2012 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22566611
2.
Antimalarial pharmacology and therapeutics of atovaquone.
J Antimicrob Chemother
; 68(5): 977-85, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23292347
3.
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
Antimicrob Agents Chemother
; 54(9): 3597-604, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20547797
4.
Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.
Bioorg Med Chem Lett
; 19(7): 2038-43, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19251414
5.
Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.
J Med Chem
; 60(9): 3703-3726, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28304162
6.
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
Angew Chem Int Ed Engl
; 49(33): 5693-7, 2010 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20629058
7.
Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.
Future Med Chem
; 5(13): 1573-91, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24024949
8.
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
J Med Chem
; 55(5): 1831-43, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364416
9.
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
J Med Chem
; 55(5): 1844-57, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364417
10.
Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.
J Med Chem
; 55(7): 3144-54, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22380711
11.
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
J Med Chem
; 53(22): 8202-6, 2010 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20979352
12.
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
J Med Chem
; 52(5): 1408-15, 2009 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19222165
13.
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
J Med Chem
; 52(7): 1828-44, 2009 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19284751