Pesquisa | Portal de Pesquisa da BVS

1.

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

Hogg, Simon J; Motorna, Olga; Cluse, Leonie A; Johanson, Timothy M; Coughlan, Hannah D; Raviram, Ramya; Myers, Robert M; Costacurta, Matteo; Todorovski, Izabela; Pijpers, Lizzy; Bjelosevic, Stefan; Williams, Tobias; Huskins, Shannon N; Kearney, Conor J; Devlin, Jennifer R; Fan, Zheng; Jabbari, Jafar S; Martin, Ben P; Fareh, Mohamed; Kelly, Madison J; Dupéré-Richer, Daphné; Sandow, Jarrod J; Feran, Breon; Knight, Deborah; Khong, Tiffany; Spencer, Andrew; Harrison, Simon J; Gregory, Gareth; Wickramasinghe, Vihandha O; Webb, Andrew I; Taberlay, Phillippa C; Bromberg, Kenneth D; Lai, Albert; Papenfuss, Anthony T; Smyth, Gordon K; Allan, Rhys S; Licht, Jonathan D; Landau, Dan A; Abdel-Wahab, Omar; Shortt, Jake; Vervoort, Stephin J; Johnstone, Ricky W.

Mol Cell ; 81(10): 2183-2200.e13, 2021 05 20.

Artigo em Inglês | MEDLINE | ID: mdl-34019788

2.

Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma.

Oh, Danielle H; Ma, Xiao; Hogg, Simon J; He, Jackson; Kearney, Conor; Brasacchio, Daniella; Susanto, Olivia; Maher, Belinda; Jennings, Ian G; Newbold, Andrea; Fraser, Peter; Gruber, Emily; Kats, Lev M; Gregory, Gareth P; Johnstone, Ricky W; Thompson, Philip E; Shortt, Jake.

Proc Natl Acad Sci U S A ; 120(36): e2306414120, 2023 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-37643213

3.

Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.

Platzbecker, Uwe; Della Porta, Matteo Giovanni; Santini, Valeria; Zeidan, Amer M; Komrokji, Rami S; Shortt, Jake; Valcarcel, David; Jonasova, Anna; Dimicoli-Salazar, Sophie; Tiong, Ing Soo; Lin, Chien-Chin; Li, Jiahui; Zhang, Jennie; Giuseppi, Ana Carolina; Kreitz, Sandra; Pozharskaya, Veronika; Keeperman, Karen L; Rose, Shelonitda; Shetty, Jeevan K; Hayati, Sheida; Vodala, Sadanand; Prebet, Thomas; Degulys, Andrius; Paolini, Stefania; Cluzeau, Thomas; Fenaux, Pierre; Garcia-Manero, Guillermo.

Lancet ; 402(10399): 373-385, 2023 07 29.

Artigo em Inglês | MEDLINE | ID: mdl-37311468

4.

Rethinking the transfusion pathway in myelodysplastic syndromes: Study protocol for a novel randomized feasibility n-of-1 trial of weekly-interval red cell transfusion in myelodysplastic syndromes.

Mo, Allison; Wood, Erica; Shortt, Jake; Charlton, Andrew; Evers, Dorothea; Hoeks, Marlijn; Pritchard, Elizabeth; Daly, James; Hodgson, Carol; Opat, Stephen; Bowen, David; Reynolds, John; Thi Phung Thao, Le; Stanworth, Simon J; McQuilten, Zoe.

Transfusion ; 64(2): 236-247, 2024 02.

Artigo em Inglês | MEDLINE | ID: mdl-38214417

5.

Use of platelet transfusions and tranexamic acid in patients with myelodysplastic syndromes: A clinical practice survey.

Mo, Allison; Weinkove, Robert; Wood, Erica M; Shortt, Jake; Johnston, Anna; McQuilten, Zoe K.

Eur J Haematol ; 112(4): 621-626, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38123137

6.

A sequential cohort study evaluating single-agent KappaMab and KappaMab combined with lenalidomide and low-dose dexamethasone in relapsed and/or refractory kappa light chain-restricted multiple myeloma (AMaRC 01-16).

Spencer, Andrew; Kalff, Anna; Shortt, Jake; Quach, Hang; Wallington-Gates, Craig; Reynolds, John; Walker, Patricia; Harrison, Simon J; Dunn, Rosanne; Wellard, Cameron.

Br J Haematol ; 202(4): 801-811, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37357593

7.

Hematologic Malignancy: Who Cares in the End? A Retrospective Cohort Study of Markers of Quality End-of-Life Care.

Shaw, Briony; Parker, Catriona; Opat, Stephen; Shortt, Jake; Poon, Peter.

J Natl Compr Canc Netw ; 21(8): 813-820.e1, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37549908

8.

Platelet transfusions and predictors of bleeding in patients with myelodysplastic syndromes.

Mo, Allison; Wood, Erica; Shortt, Jake; Hu, Erin; McQuilten, Zoe.

Eur J Haematol ; 111(4): 592-600, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37452616

9.

High risk of infection in 'real-world' patients receiving ibrutinib, idelalisib or venetoclax for mature B-cell leukaemia/lymphoma.

Tey, Amanda; Schwarer, James; Raffa, Robert; Shi, Emily; Paul, Eldho; Opat, Stephen; Dendle, Claire; Shortt, Jake.

Eur J Haematol ; 110(5): 540-547, 2023 May.

Artigo em Inglês | MEDLINE | ID: mdl-36656100

10.

Low mortality in vaccinated immunocompromised haematology patients infected with SARS-CoV-2.

Shaw, Briony; Shortt, Jake; Low, Michael; Rogers, Benjamin; Kaplan, Zane; Fedele, Pasquale; Gregory, Gareth; Vilcassim, Shahla; Gilbertson, Michael; Grigoriadis, George; Opat, Stephen.

Intern Med J ; 52(12): 2172-2175, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36436197

11.

Diagnosis, management and follow up of peripheral T-cell lymphomas: a consensus practice statement from the Australasian Lymphoma Alliance.

Hapgood, Greg; Latimer, Maya; Lee, Sze Ting; Kuss, Bryone; Lade, Stephen; Tobin, Joshua W D; Purtill, Duncan; Campbell, Belinda A; Prince, H Miles; Hawkes, Eliza A; Shortt, Jake; Radeski, Dejan.

Intern Med J ; 52(10): 1806-1817, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-34668281

12.

Mezigdomide and Multiple Myeloma.

Shortt, Jake.

N Engl J Med ; 389(11): 1046-1050, 2023 Sep 14.

Artigo em Inglês | MEDLINE | ID: mdl-37646699

13.

Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma.

Costacurta, Matteo; Vervoort, Stephin J; Hogg, Simon J; Martin, Benjamin P; Johnstone, Ricky W; Shortt, Jake.

Haematologica ; 106(7): 2013-2017, 2021 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-33375771

14.

Risk factors for invasive fungal infection in 5-azacytidine treated patients with acute myeloid leukemia and myelodysplastic syndrome.

Tey, Amanda; Shaw, Briony; Cardamone, Luke; Shepherd, Sam; Paul, Eldho; Rogers, Ben; Shortt, Jake.

Eur J Haematol ; 107(2): 181-189, 2021 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-33829584

15.

Prediction of cardiovascular events in patients with chronic myeloid leukaemia using baseline risk factors and coronary artery calcium scoring.

Baggio, Diva; Tan, Sean; Porch, Kylie; Shortt, Jake; Ko, Brian.

Intern Med J ; 51(10): 1736-1740, 2021 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-34664363

16.

Excellent outcomes of transformed lymphomas in the rituximab era without autologous stem cell transplantation: an Australian single-centre experience.

Tedjaseputra, Aditya; Gilbertson, Michael; Low, Michael; Fedele, Pasquale L; Kumar, Beena; Simpson, Ian; Grigoriadis, George; Shortt, Jake; Opat, Stephen; Gregory, Gareth P.

Intern Med J ; 51(11): 1825-1834, 2021 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-32609419

17.

Mycosis fungoides and Sézary syndrome: Australian clinical practice statement.

Bhabha, Friyana K; McCormack, Christopher; Wells, Jillian; Campbell, Belinda A; Newland, Kate; Lade, Stephen; Buelens, Odette; Joske, David; Shortt, Jake; Mapp, Sally; Radeski, Dejan; Hertzberg, Mark; Khot, Amit; Van Der Weyden, Carrie; Khoo, Christine; Hawkes, Eliza; Prince, H Miles.

Australas J Dermatol ; 62(1): e8-e18, 2021 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-33368169

18.

Chronic myeloid leukaemia and tyrosine kinase inhibitor therapy: assessment and management of cardiovascular risk factors.

Ross, David M; Arthur, Chris; Burbury, Kate; Ko, Brian S; Mills, Anthony K; Shortt, Jake; Kostner, Karam.

Intern Med J ; 48 Suppl 2: 5-13, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29388307

19.

Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand.

Fox, Lucy C; Cohney, Solomon J; Kausman, Joshua Y; Shortt, Jake; Hughes, Peter D; Wood, Erica M; Isbel, Nicole M; de Malmanche, Theo; Durkan, Anne; Hissaria, Pravin; Blombery, Piers; Barbour, Thomas D.

Intern Med J ; 48(6): 624-636, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29582550

20.

Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand.

Fox, Lucy C; Cohney, Solomon J; Kausman, Joshua Y; Shortt, Jake; Hughes, Peter D; Wood, Erica M; Isbel, Nicole M; de Malmanche, Theo; Durkan, Anne; Hissaria, Pravin; Blombery, Piers; Barbour, Thomas D.

Nephrology (Carlton) ; 23(6): 507-517, 2018 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-29419916

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Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma.

Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.

Rethinking the transfusion pathway in myelodysplastic syndromes: Study protocol for a novel randomized feasibility n-of-1 trial of weekly-interval red cell transfusion in myelodysplastic syndromes.

Use of platelet transfusions and tranexamic acid in patients with myelodysplastic syndromes: A clinical practice survey.

A sequential cohort study evaluating single-agent KappaMab and KappaMab combined with lenalidomide and low-dose dexamethasone in relapsed and/or refractory kappa light chain-restricted multiple myeloma (AMaRC 01-16).

Hematologic Malignancy: Who Cares in the End? A Retrospective Cohort Study of Markers of Quality End-of-Life Care.

Platelet transfusions and predictors of bleeding in patients with myelodysplastic syndromes.

High risk of infection in 'real-world' patients receiving ibrutinib, idelalisib or venetoclax for mature B-cell leukaemia/lymphoma.

Low mortality in vaccinated immunocompromised haematology patients infected with SARS-CoV-2.

Diagnosis, management and follow up of peripheral T-cell lymphomas: a consensus practice statement from the Australasian Lymphoma Alliance.

Mezigdomide and Multiple Myeloma.

Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma.

Risk factors for invasive fungal infection in 5-azacytidine treated patients with acute myeloid leukemia and myelodysplastic syndrome.

Prediction of cardiovascular events in patients with chronic myeloid leukaemia using baseline risk factors and coronary artery calcium scoring.

Excellent outcomes of transformed lymphomas in the rituximab era without autologous stem cell transplantation: an Australian single-centre experience.

Mycosis fungoides and Sézary syndrome: Australian clinical practice statement.

Chronic myeloid leukaemia and tyrosine kinase inhibitor therapy: assessment and management of cardiovascular risk factors.

Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand.

Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand.