Pesquisa | Portal de Pesquisa da BVS

1.

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.

Warren, Travis K; Jordan, Robert; Lo, Michael K; Ray, Adrian S; Mackman, Richard L; Soloveva, Veronica; Siegel, Dustin; Perron, Michel; Bannister, Roy; Hui, Hon C; Larson, Nate; Strickley, Robert; Wells, Jay; Stuthman, Kelly S; Van Tongeren, Sean A; Garza, Nicole L; Donnelly, Ginger; Shurtleff, Amy C; Retterer, Cary J; Gharaibeh, Dima; Zamani, Rouzbeh; Kenny, Tara; Eaton, Brett P; Grimes, Elizabeth; Welch, Lisa S; Gomba, Laura; Wilhelmsen, Catherine L; Nichols, Donald K; Nuss, Jonathan E; Nagle, Elyse R; Kugelman, Jeffrey R; Palacios, Gustavo; Doerffler, Edward; Neville, Sean; Carra, Ernest; Clarke, Michael O; Zhang, Lijun; Lew, Willard; Ross, Bruce; Wang, Queenie; Chun, Kwon; Wolfe, Lydia; Babusis, Darius; Park, Yeojin; Stray, Kirsten M; Trancheva, Iva; Feng, Joy Y; Barauskas, Ona; Xu, Yili; Wong, Pamela.

Nature ; 531(7594): 381-5, 2016 Mar 17.

Artigo em Inglês | MEDLINE | ID: mdl-26934220

2.

Medical countermeasures against henipaviruses: a review and public health perspective.

Gómez Román, Raúl; Tornieporth, Nadia; Cherian, Neil George; Shurtleff, Amy C; L'Azou Jackson, Maïna; Yeskey, Debra; Hacker, Adam; Mungai, Eric; Le, Tung Thanh.

Lancet Infect Dis ; 22(1): e13-e27, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34735799

3.

A STAT-1 knockout mouse model for Machupo virus pathogenesis.

Bradfute, Steven B; Stuthman, Kelly S; Shurtleff, Amy C; Bavari, Sina.

Virol J ; 8: 300, 2011 Jun 14.

Artigo em Inglês | MEDLINE | ID: mdl-21672221

4.

Opportunities for Refinement of Non-Human Primate Vaccine Studies.

Prescott, Mark J; Clark, Carolyn; Dowling, William E; Shurtleff, Amy C.

Vaccines (Basel) ; 9(3)2021 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-33808708

5.

Natural history of disease in cynomolgus monkeys exposed to Ebola virus Kikwit strain demonstrates the reliability of this non-human primate model for Ebola virus disease.

Niemuth, Nancy A; Fallacara, Dawn; Triplett, Cheryl A; Tamrakar, Sanjay M; Rajbhandari, Alisha; Florence, Clint; Ward, Lucy; Griffiths, Anthony; Carrion, Ricardo; Goez-Gazi, Yenny; Alfson, Kendra J; Staples, Hilary M; Brasel, Trevor; Comer, Jason E; Massey, Shane; Smith, Jeanon; Kocsis, Andrew; Lowry, Jake; Johnston, Sara C; Nalca, Aysegul; Goff, Arthur J; Shurtleff, Amy C; Pitt, Margaret L; Trefry, John; Fay, Michael P.

PLoS One ; 16(7): e0252874, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34214118

6.

Recent successes in therapeutics for Ebola virus disease: no time for complacency.

Iversen, Patrick L; Kane, Christopher D; Zeng, Xiankun; Panchal, Rekha G; Warren, Travis K; Radoshitzky, Sheli R; Kuhn, Jens H; Mudhasani, Rajini R; Cooper, Christopher L; Shurtleff, Amy C; Nasar, Farooq; Sunay, Melek Me; Duplantier, Allen J; Eaton, Brett P; Zumbrun, Elizabeth E; Bixler, Sandra L; Martin, Shannon; Meinig, J Matthew; Chiang, Chih-Yuan; Sanchez-Lockhart, Mariano; Palacios, Gustavo F; Kugelman, Jeffrey R; Martins, Karen A; Pitt, Margaret L; Crozier, Ian; Saunders, David L.

Lancet Infect Dis ; 20(9): e231-e237, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32563280

7.

High degree of correlation between Ebola virus BSL-4 neutralization assays and pseudotyped VSV BSL-2 fluorescence reduction neutralization test.

Konduru, Krishnamurthy; Shurtleff, Amy C; Bavari, Sina; Kaplan, Gerardo.

J Virol Methods ; 254: 1-7, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29355585

8.

Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo.

Warfield, Kelly L; Warren, Travis K; Qiu, Xiangguo; Wells, Jay; Mire, Chad E; Geisbert, Joan B; Stuthman, Kelly S; Garza, Nicole L; Van Tongeren, Sean A; Shurtleff, Amy C; Agans, Krystle N; Wong, Gary; Callahan, Michael V; Geisbert, Thomas W; Klose, Brennan; Ramstedt, Urban; Treston, Anthony M.

Antiviral Res ; 138: 22-31, 2017 02.

Artigo em Inglês | MEDLINE | ID: mdl-27908828

9.

Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses.

Bolken, Tove C; Laquerre, Sylvie; Zhang, Yuanming; Bailey, Thomas R; Pevear, Daniel C; Kickner, Shirley S; Sperzel, Lindsey E; Jones, Kevin F; Warren, Travis K; Amanda Lund, S; Kirkwood-Watts, Dana L; King, David S; Shurtleff, Amy C; Guttieri, Mary C; Deng, Yijun; Bleam, Maureen; Hruby, Dennis E.

Antiviral Res ; 69(2): 86-97, 2006 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-16343651

10.

Ebolavirus Glycoprotein Fc Fusion Protein Protects Guinea Pigs against Lethal Challenge.

Konduru, Krishnamurthy; Shurtleff, Amy C; Bradfute, Steven B; Nakamura, Siham; Bavari, Sina; Kaplan, Gerardo.

PLoS One ; 11(9): e0162446, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27622456

11.

Validation of the Filovirus Plaque Assay for Use in Preclinical Studies.

Shurtleff, Amy C; Bloomfield, Holly A; Mort, Shannon; Orr, Steven A; Audet, Brian; Whitaker, Thomas; Richards, Michelle J; Bavari, Sina.

Viruses ; 8(4): 113, 2016 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-27110807

12.

Development of a new vaccine for the prevention of Lassa fever.

Geisbert, Thomas W; Jones, Steven; Fritz, Elizabeth A; Shurtleff, Amy C; Geisbert, Joan B; Liebscher, Ryan; Grolla, Allen; Ströher, Ute; Fernando, Lisa; Daddario, Kathleen M; Guttieri, Mary C; Mothé, Bianca R; Larsen, Tom; Hensley, Lisa E; Jahrling, Peter B; Feldmann, Heinz.

PLoS Med ; 2(6): e183, 2005 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-15971954

13.

Animal models for ebolavirus countermeasures discovery: what defines a useful model?

Shurtleff, Amy C; Bavari, Sina.

Expert Opin Drug Discov ; 10(7): 685-702, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-26004783

14.

Pre-symptomatic diagnosis and treatment of filovirus diseases.

Shurtleff, Amy C; Whitehouse, Chris A; Ward, Michael D; Cazares, Lisa H; Bavari, Sina.

Front Microbiol ; 6: 108, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25750638

15.

Evaluation of Ebola Virus Inhibitors for Drug Repurposing.

Madrid, Peter B; Panchal, Rekha G; Warren, Travis K; Shurtleff, Amy C; Endsley, Aaron N; Green, Carol E; Kolokoltsov, Andrey; Davey, Robert; Manger, Ian D; Gilfillan, Lynne; Bavari, Sina; Tanga, Mary J.

ACS Infect Dis ; 1(7): 317-26, 2015 Jul 10.

Artigo em Inglês | MEDLINE | ID: mdl-27622822

16.

Cross-protection conferred by filovirus virus-like particles containing trimeric hybrid glycoprotein.

Martins, Karen; Carra, John H; Cooper, Christopher L; Kwilas, Steven A; Robinson, Camenzind G; Shurtleff, Amy C; Schokman, Rowena D; Kuehl, Kathleen A; Wells, Jay B; Steffens, Jesse T; van Tongeren, Sean A; Hooper, Jay W; Bavari, Sina.

Viral Immunol ; 28(1): 62-70, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25514232

17.

TMC-114 (Tibotec).

Shurtleff, Amy C.

Curr Opin Investig Drugs ; 5(8): 879-86, 2004 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-15600245

18.

Bioterrorism and emerging infectious disease - antimicrobials, therapeutics and immune-modulators. SARS coronavirus.

Shurtleff, Amy C.

IDrugs ; 7(2): 91-5, 2004 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-15057645

19.

HSPA5 is an essential host factor for Ebola virus infection.

Reid, St Patrick; Shurtleff, Amy C; Costantino, Julie A; Tritsch, Sarah R; Retterer, Cary; Spurgers, Kevin B; Bavari, Sina.

Antiviral Res ; 109: 171-4, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-25017472

20.

Marburgvirus hijacks nrf2-dependent pathway by targeting nrf2-negative regulator keap1.

Page, Audrey; Volchkova, Valentina A; Reid, Saint Patrick; Mateo, Mathieu; Bagnaud-Baule, Audrey; Nemirov, Kirill; Shurtleff, Amy C; Lawrence, Philip; Reynard, Oliver; Ottmann, Michele; Lotteau, Vincent; Biswal, Shyam S; Thimmulappa, Rajesh K; Bavari, Sina; Volchkov, Viktor E.

Cell Rep ; 6(6): 1026-1036, 2014 Mar 27.

Artigo em Inglês | MEDLINE | ID: mdl-24630992

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