Brucellosis Causes Alteration in Trace Elements and Oxidative Stress Factors.

Brucellosis is regarded as one of the most common diseases among humans and livestock. In the present study, we aimed to assess the effect of this disease on the level of various cations including copper (Cu), manganese (Mn), zinc (Zn), and magnesium (Mg) as well as oxidative stress status in the serum of people suffering from brucellosis. The present case-study was carried out on 40 patients with brucellosis (case) and 20 healthy people (control). Blood specimens were taken from all the people and the level of essential trace elements and oxidative stress status were measured. The serum level of copper in the case group (165.39 ± 43.19 µg/dl) was significantly higher compared with that in the control group (122.12 ± 28.88 µg/dl). Whereas the serum level of zinc was significantly lower in the case group compared with that in the control group (76.47 ± 28.88 vs. 92.85 ± 23.16 µg/dl). The manganese and magnesium serum levels did not differ significantly between the two groups. Furthermore, total antioxidant capacity level was significantly lower in the case group (122.12 ± 28.22 µmol/ml) than that in the control group (3.08 ± 0.12 µmol/ml) and the level of serum malondialdehyde was significantly higher in the case group (7.20 ± 0.23 mmol/ml) than that in the control group (4.0 ± 0.19 mmol/ml). Brucellosis can cause alteration in the serum level of essential trace elements. Moreover, the present study indicated that brucellosis produces oxidative stress in patients.

Investigation of the correlation between some immune system and biochemical indicators in patients with type 2 diabetes.

AIMS/INTRODUCTION: Since changes in some immune system indicators such as leukocyte count and neutrophil to lymphocyte ratio in the blood and Inflammation is directly in relation with the pathogenesis of type 2 diabetes, metabolic syndrome and atherosclerosis, measuring these indicators in patients with type 2 diabetes and comparing them with control group can be a suitable indicator of Inflammation and prognosis of the disease. MATERIALS AND METHODS: The current study was done on 75 patients with type 2 diabetes and 72 healthy individuals as patient and healthy group respectively. The selected groups have been matched for age and sex. Fasting blood sugar, lipid profile including triglycerides, total cholesterol, HDL, LDL, as well as the number of white blood cells, neutrophils, lymphocytes, neutrophils to lymphocytes ratio were measured and analyzed in both groups. RESULTS: The results demonstrated that there is a significant relationship between the number of white blood cells and increase in blood sugar and also between the neutrophil to lymphocyte ratio and increase in Fasting blood sugar and triglycerides parameters. Furthermore, the average of fasting blood sugar, triglycerides, total cholesterol, LDL and neutrophil to lymphocyte ratio in patient with type 2 diabetes is significantly higher than control group. CONCLUSION: Considering the findings of current study, we showed the inflammation and the pathogenesis caused by type 2 diabetes can be attributed to neutrophil to lymphocyte ratio.