RESUMO
Hepar lobatum is now a rarity in developed countries. In this article, we describe three cases with typical liver morphology associated with carcinoma of the breast metastatic to the liver, treated with combination chemotherapy. The pathogenesis of hepar lobatum in our cases is multifactorial with tumor-related desmoplasia and effects of chemotherapy, with resultant tumor necrosis and fibrosis playing a major role.
Assuntos
Adenocarcinoma/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias da Mama , Carcinoma Intraductal não Infiltrante/tratamento farmacológico , Neoplasias Hepáticas/tratamento farmacológico , Fígado/patologia , Adenocarcinoma/secundário , Neoplasias da Mama/tratamento farmacológico , Carcinoma Intraductal não Infiltrante/secundário , Feminino , Humanos , Fígado/efeitos dos fármacos , Neoplasias Hepáticas/secundário , Pessoa de Meia-IdadeRESUMO
We present the cytologic features and the immunocytochemical profile of four cases of chordoma on fine-needle aspiration biopsies. The physaliferous cells in signet-ring, pearl-like formations and the trabecular arrangement with rounded contours are distinctive. Other cell types and cellular arrangements are also described. The negative immunoreactivity of carcinoembryonic antigen (CEA) and the positive staining pattern for neuron-specific enolase (NSE), S-100 protein, epithelial membrane antigen (EMA), and keratin provide a profile that, in the appropriate clinical setting, can be useful in the differential diagnosis of chordoma from similar-appearing neoplasms in small biopsies and fine-needle aspirates.
Assuntos
Neoplasias Encefálicas/patologia , Cordoma/patologia , Adulto , Idoso , Antígenos/análise , Biópsia por Agulha , Neoplasias Encefálicas/diagnóstico , Antígeno Carcinoembrionário/análise , Cordoma/diagnóstico , Feminino , Humanos , Técnicas Imunoenzimáticas , Queratinas/análise , Masculino , Proteínas de Membrana/análise , Pessoa de Meia-Idade , Mucina-1 , Fosfopiruvato Hidratase/análise , Proteínas S100/análiseRESUMO
Fine needle aspiration biopsy of the major salivary glands was performed on 160 patients. In 146 patients with satisfactory samples, the cytologic diagnosis was correlated with clinical follow-up and histologic findings. There were 122 benign lesions, including 47 tumors. There were 24 malignant lesions, 10 of which were primary and 14 metastatic. The overall accuracy was 98%. The sensitivity of the technique was 87.5%. There was no false-positive diagnosis. There were three false-negative diagnoses due to sampling errors and inexperience during the initial period of the study. This study documents that needle aspiration biopsy cytology of the salivary glands is accurate, simple, rapid, inexpensive, well tolerated and harmless to the patient.