Detalhe da pesquisa
1.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
2.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
3.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
4.
Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria.
Br J Clin Pharmacol
; 80(4): 706-15, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25966781
5.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
6.
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
Nat Commun
; 8: 15159, 2017 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28537265
7.
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
J Med Chem
; 46(12): 2413-26, 2003 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12773045
8.
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.
Nat Commun
; 5: 5521, 2014 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25422853
9.
Drug attrition during pre-clinical and clinical development: understanding and managing drug-induced cardiotoxicity.
Pharmacol Ther
; 138(3): 470-84, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23507039
10.
Quinolone-3-diarylethers: a new class of antimalarial drug.
Sci Transl Med
; 5(177): 177ra37, 2013 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23515079
11.
Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society.
J Pharmacol Toxicol Methods
; 64(1): 7-15, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21689769
12.
New preclinical guidelines on drug effects on ventricular repolarization: safety pharmacology comes of age.
J Pharmacol Toxicol Methods
; 49(3): 153-8, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15172011