Detalhe da pesquisa
1.
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.
Cell
; 183(6): 1714-1731.e10, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33275901
2.
Discovery of a selective inhibitor of doublecortin like kinase 1.
Nat Chem Biol
; 16(6): 635-643, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32251410
3.
Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails.
J Enzyme Inhib Med Chem
; 37(1): 1257-1277, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35484863
4.
Natural and Synthetic Lactones Possessing Antitumor Activities.
Int J Mol Sci
; 22(3)2021 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33494352
5.
Novel and Potent Small Molecules against Melanoma Harboring BRAF Class I/II/III Mutants for Overcoming Drug Resistance.
Int J Mol Sci
; 22(7)2021 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33917428
6.
Suppression of TRPM7 enhances TRAIL-induced apoptosis in triple-negative breast cancer cells.
J Cell Physiol
; 235(12): 10037-10050, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32468675
7.
The first small molecules capable of strongly suppressing proliferation of cancer cells harboring BRAF class I/II/III mutations.
Biochem Biophys Res Commun
; 532(2): 315-320, 2020 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32873393
8.
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
Nature
; 511(7511): 616-20, 2014 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043025
9.
Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.
Bioorg Med Chem Lett
; 29(15): 1985-1993, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31175010
10.
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as potent ALK-L1196M inhibitors.
J Enzyme Inhib Med Chem
; 34(1): 1426-1438, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31401883
11.
Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors.
Bioorg Med Chem Lett
; 28(23-24): 3761-3765, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30340900
12.
Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach.
Blood
; 125(20): 3133-43, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25833960
13.
Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion.
Biochim Biophys Acta Gen Subj
; 1861(4): 947-957, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28161478
14.
Structural Revision of Baulamycin A and Structure-Activity Relationships of Baulamycin A Derivatives.
J Org Chem
; 82(24): 12947-12966, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28903000
15.
Characterization of a highly selective inhibitor of the Aurora kinases.
Bioorg Med Chem Lett
; 27(18): 4405-4408, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28818446
16.
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc Natl Acad Sci U S A
; 111(45): E4869-77, 2014 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349422
17.
Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
J Biol Chem
; 295(9): 2886, 2020 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32111721
18.
Pharmacological targeting of the pseudokinase Her3.
Nat Chem Biol
; 10(12): 1006-12, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25326665
19.
Synthesis of novel arylaminoquinazolinylurea derivatives and their antiproliferative activities against bladder cancer cell line.
Bioorg Med Chem Lett
; 26(20): 5082-5086, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27599742
20.
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Nature
; 463(7280): 501-6, 2010 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20072125