Detalhe da pesquisa
1.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature
; 550(7677): 481-486, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29045389
2.
Gene expression analysis in biomarker research and early drug development using function tested reverse transcription quantitative real-time PCR assays.
Methods
; 59(1): 10-9, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22796720
3.
CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies.
Clin Cancer Res
; 26(8): 1953-1964, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31964784
4.
Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors.
Clin Cancer Res
; 22(4): 858-67, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26446946
5.
A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers.
Clin Cancer Res
; 21(2): 258-66, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25388164
6.
RG7212 anti-TWEAK mAb inhibits tumor growth through inhibition of tumor cell proliferation and survival signaling and by enhancing the host antitumor immune response.
Clin Cancer Res
; 19(20): 5686-98, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23974006
7.
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
Cancer Res
; 72(3): 779-89, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22180495
8.
Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation.
Cancer Res
; 72(4): 969-78, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22205714
9.
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models.
Cancer Res
; 70(13): 5518-27, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20551065
10.
Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.
Bioorg Med Chem Lett
; 16(7): 1950-3, 2006 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16460940
11.
RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation.
Bioorg Med Chem
; 13(16): 4835-41, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15953730
12.
A new series of potent oxindole inhibitors of CDK2.
Bioorg Med Chem Lett
; 14(4): 913-7, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15012993
13.
3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors.
Bioorg Med Chem Lett
; 13(15): 2465-8, 2003 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12852944