Detalhe da pesquisa
1.
Cholesterol Inhibition of Slo1 Channels Is Calcium-Dependent and Can Be Mediated by Either High-Affinity Calcium-Sensing Site in the Slo1 Cytosolic Tail.
Mol Pharmacol
; 101(3): 132-143, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34969832
2.
Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na+ Channel 1.6 Enables Isoform-Selective Modulation.
Int J Mol Sci
; 22(24)2021 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34948337
3.
Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions.
Bioorg Med Chem Lett
; 29(3): 413-419, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30587448
4.
Identification of Amino Acid Residues in Fibroblast Growth Factor 14 (FGF14) Required for Structure-Function Interactions with Voltage-gated Sodium Channel Nav1.6.
J Biol Chem
; 291(21): 11268-84, 2016 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26994141
5.
CK2 activity is required for the interaction of FGF14 with voltage-gated sodium channels and neuronal excitability.
FASEB J
; 30(6): 2171-86, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26917740
6.
An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel.
Proc Natl Acad Sci U S A
; 111(25): 9313-8, 2014 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24927535
7.
The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory ß1 subunit.
Proc Natl Acad Sci U S A
; 108(50): 20207-12, 2011 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22123969
8.
Distinct sensitivity of slo1 channel proteins to ethanol.
Mol Pharmacol
; 83(1): 235-44, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23093494
9.
Multiple cholesterol recognition/interaction amino acid consensus (CRAC) motifs in cytosolic C tail of Slo1 subunit determine cholesterol sensitivity of Ca2+- and voltage-gated K+ (BK) channels.
J Biol Chem
; 287(24): 20509-21, 2012 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22474334
10.
Fibroblast growth factor 13-mediated regulation of medium spiny neuron excitability and cocaine self-administration.
Front Neurosci
; 17: 1294567, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38099204
11.
Aggregation-prone near-native intermediate formation during unfolding of a structurally similar nonlenticular ßγ-crystallin domain.
Biochemistry
; 51(43): 8502-13, 2012 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043265
12.
Structure of the catalytic chain of Methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 5): 527-34, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22691781
13.
Bioluminescence Methodology for Ion Channel Studies.
Methods Mol Biol
; 2188: 191-228, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33119853
14.
Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na+ Channel 1.2 Macromolecular Complex.
Cells
; 10(11)2021 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34831326
15.
Differential Modulation of the Voltage-Gated Na+ Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14.
Front Mol Biosci
; 8: 742903, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34557523
16.
Effects of Deltamethrin Acute Exposure on Nav1.6 Channels and Medium Spiny Neurons of the Nucleus Accumbens.
Toxicology
; 440: 152488, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32387285
17.
JAK2 regulates Nav1.6 channel function via FGF14Y158 phosphorylation.
Biochim Biophys Acta Mol Cell Res
; 1867(10): 118786, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32599005
18.
Design, Synthesis, and Pharmacological Evaluation of Analogues Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6.
J Med Chem
; 63(20): 11522-11547, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33054193
19.
Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability.
Physiol Rep
; 8(14): e14505, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32671946
20.
High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na+ channel complex.
Sci Rep
; 9(1): 16890, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31729429