RESUMO
The "weekend effect" has been widely studied in various health care settings, but it has received less attention in the field of transplantation. The study by Mohan et al. reveals that this phenomenon exists in discard rates for deceased donor kidneys in the United States. These findings emphasize the importance of reducing unexplained variations in kidney discard rates, especially in light of the ongoing shortage of transplantable organs.
Assuntos
Transplante de Rim , Obtenção de Tecidos e Órgãos , Humanos , Rim , Doadores de Tecidos , Estados UnidosRESUMO
PURPOSE OF REVIEW: This review discusses the recent evidence that intrinsic glomerular cells including podocytes, parietal epithelial cells and progenitor cells within Bowman's capsule contribute to cellular crescents. RECENT FINDINGS: Using a variety of newer molecular markers and lineage tracing experiments, investigators have clearly demonstrated that glomerular cells play a key role in the development and progression of cellular crescents in experimental and human disease. SUMMARY: Crescentic glomerulonephritis is associated with significant morbidity and mortality. Current therapies target the immune system. The recent finding that nonimmune cells also play a role in crescent formation highlights the need to identify alternate and complimentary therapeutic strategies.