Detalhe da pesquisa
1.
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats.
Toxicol Pathol
; : 1926233241248656, 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742644
2.
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.
Toxicol Pathol
; 51(1-2): 15-26, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37078689
3.
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling.
Toxicol Pathol
; 50(1): 35-46, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34657537
4.
Survey of tumorigenic sensitivity in 6-month rasH2-Tg mice studies compared with 2-year rodent assays.
J Toxicol Pathol
; 35(1): 53-73, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-35221496
5.
A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery.
Drug Metab Dispos
; 48(11): 1147-1160, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32943412
6.
Evaluation of 10 Urinary Biomarkers for Renal Safety With 5 Nephrotoxicants in Nonhuman Primates.
Toxicol Pathol
; 48(5): 633-648, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32633702
7.
Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices.
Int J Toxicol
; 39(3): 198-206, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32372678
8.
Can Galactose Be Converted to Glucose in HepG2 Cells? Improving the in Vitro Mitochondrial Toxicity Assay for the Assessment of Drug Induced Liver Injury.
Chem Res Toxicol
; 32(8): 1528-1544, 2019 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31271030
9.
Adverse outcome pathway-driven identification of rat liver tumorigens in short-term assays.
Toxicol Appl Pharmacol
; 356: 99-113, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30048669
10.
Performance Assessment of New Urinary Translational Safety Biomarkers of Drug-induced Renal Tubular Injury in Tenofovir-treated Cynomolgus Monkeys and Beagle Dogs.
Toxicol Pathol
; 46(5): 553-563, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29807506
11.
Vascular Imaging of Matrix Metalloproteinase Activity as an Informative Preclinical Biomarker of Drug-induced Vascular Injury.
Toxicol Pathol
; 45(5): 633-648, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28830331
12.
Role of chronic toxicology studies in revealing new toxicities.
Regul Toxicol Pharmacol
; 82: 94-98, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27769827
13.
Regulatory Forum Commentary* Counterpoint: Dose Selection for Tg.rasH2 Mouse Carcinogenicity Studies.
Toxicol Pathol
; 43(5): 621-7, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26047967
14.
Regulatory Forum commentary: alternative mouse models for future cancer risk assessment.
Toxicol Pathol
; 42(5): 799-806, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23965809
15.
A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures.
Toxicol Res (Camb)
; 13(1): tfad120, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38223529
16.
Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in male rats.
Birth Defects Res B Dev Reprod Toxicol
; 98(1): 41-53, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23348767
17.
Medical applications of microarray technologies: a regulatory science perspective.
Nat Genet
; 32 Suppl: 474-9, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12454641
18.
Using human genetics to improve safety assessment of therapeutics.
Nat Rev Drug Discov
; 22(2): 145-162, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36261593
19.
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin.
Toxicol Sci
; 187(2): 219-233, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35285504
20.
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.
Toxicol Sci
; 188(1): 4-16, 2022 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404422