Detalhe da pesquisa
1.
Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis.
J Lipid Res
; 54(1): 177-88, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23103473
2.
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
EMBO Rep
; 12(12): 1300-5, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22081141
3.
Clinical and Regulatory Challenges and Opportunities for Monoclonal Antibodies in Low- and Middle-Income Countries: Lessons from COVID-19 and Beyond.
Pharmaceut Med
; 37(3): 203-214, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37115494
4.
Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice.
J Lipid Res
; 53(8): 1654-61, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22611251
5.
Measurement of fractional synthetic rates of multiple protein analytes by triple quadrupole mass spectrometry.
Clin Chem
; 58(3): 619-27, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22249652
6.
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.
J Lipid Res
; 52(1): 78-86, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20959675
7.
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.
J Biol Chem
; 285(17): 12882-91, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20172854
8.
Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.
Proc Natl Acad Sci U S A
; 105(14): 5337-42, 2008 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18391212
9.
PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.
J Lipid Res
; 51(9): 2611-8, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20453200
10.
Biochemical characterization of cholesteryl ester transfer protein inhibitors.
J Lipid Res
; 51(9): 2739-52, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20458119
11.
Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.
Bioorg Med Chem
; 16(16): 7535-42, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18691892
12.
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
J Med Chem
; 47(10): 2441-52, 2004 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15115388
13.
Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation.
J Steroid Biochem Mol Biol
; 88(2): 191-201, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084351
14.
Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism.
J Steroid Biochem Mol Biol
; 92(5): 345-56, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15698539
15.
An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes.
Int J Biol Sci
; 8(3): 310-27, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22355267
16.
Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants.
J Biol Chem
; 284(2): 1313-23, 2009 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19001363
17.
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
J Lipid Res
; 49(6): 1333-43, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18354137
18.
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation.
J Biol Chem
; 282(28): 20502-12, 2007 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17493938
19.
Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.
Bioorg Med Chem Lett
; 17(12): 3354-61, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17467988
20.
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Bioorg Med Chem Lett
; 15(8): 2163-7, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15808489