Detalhe da pesquisa
1.
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.
Nat Chem Biol
; 16(10): 1052-1061, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690944
2.
Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia.
Genome Res
; 28(4): 423-431, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29567674
3.
Chemical validation and optimization of pharmacoperones targeting vasopressin type 2 receptor mutant.
Biochem J
; 475(18): 2941-2953, 2018 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30068530
4.
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.
Bioorg Med Chem Lett
; 26(17): 4282-6, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476142
5.
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
Bioorg Med Chem Lett
; 26(13): 3029-3033, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27185330
6.
Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.
Bioorg Med Chem Lett
; 25(2): 384-8, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25435150
7.
Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.
Pharmacol Res
; 83: 38-51, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24373832
8.
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes.
SLAS Discov
; 29(3): 100148, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38677875
9.
Target-based discovery of a broad-spectrum flukicide.
Nat Struct Mol Biol
; 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38714890
10.
Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.
J Med Chem
; 67(3): 1949-1960, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38252624
11.
Discovery of ML326: The first sub-micromolar, selective M5 PAM.
Bioorg Med Chem Lett
; 23(10): 2996-3000, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562060
12.
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2.
SLAS Discov
; 28(3): 95-101, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36646172
13.
Target-based discovery of a broad spectrum flukicide.
bioRxiv
; 2023 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37790347
14.
Abrogation of complex glycosylation by swainsonine results in strain- and cell-specific inhibition of prion replication.
J Biol Chem
; 286(47): 40962-73, 2011 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21930694
15.
High throughput screening for compounds to the orphan nuclear receptor NR2F6.
SLAS Discov
; 27(4): 242-248, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35331960
16.
Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR.
SLAS Discov
; 26(2): 205-215, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33016182
17.
Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel.
PLoS Negl Trop Dis
; 15(11): e0009898, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34731172
18.
Prion strain discrimination in cell culture: the cell panel assay.
Proc Natl Acad Sci U S A
; 104(52): 20908-13, 2007 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18077360
19.
Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity.
Sci Rep
; 10(1): 10579, 2020 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32601341
20.
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2.
SLAS Discov
; 25(10): 1152-1161, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33043784