1.
Pharmazie
; 62(4): 243-54, 2007 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17484277
RESUMO
Design, synthesis and biochemical evaluation of a series of novel non-covalent thrombin inhibitors with a 1-amidinopiperidine moiety are presented. Replacement of the planar benzamidine group in azaphenylalanine derivatives with 1-amidinopiperidine resulted in lower activity but higher selectivity for this type of compounds. The binding conformation of inhibitors in the active site of thrombin was revealed by molecular modelling studies.