Detalhe da pesquisa
1.
The in vitro effect of anticoagulant agents on coagulation and fibrinolysis in the presence of emicizumab in the plasmas from patients with haemophilia A.
Haemophilia
; 29(6): 1529-1538, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37766492
2.
Anti-idiotype monoclonal antibodies against emicizumab enable accurate procoagulant and anticoagulant assays, irrespective of the test base, in the presence of emicizumab.
Haemophilia
; 29(1): 329-335, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36137299
3.
Coagulant potentials of emicizumab in the plasmas from infant and toddler patients with hemophilia A.
Pediatr Blood Cancer
; 70(10): e30590, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37467119
4.
The use of infrared thermography for non-invasive detection of bleeding and musculoskeletal abnormalities in patients with hemophilia: an observational study.
Thromb J
; 21(1): 70, 2023 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37381012
5.
Emicizumab improves the stability and structure of fibrin clot derived from factor VIII-deficient plasma, similar to the addition of factor VIII.
Haemophilia
; 26(3): e97-e105, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32157756
6.
Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A.
Blood
; 124(20): 3165-71, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25274508
7.
Reduced plasma factor X is associated with a lack of response to recombinant activated factor VII in patients with hemophilia A and inhibitor, but does not impair emicizumab-driven hemostasis in vitro.
Thromb Res
; 237: 37-45, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38547693
8.
Emicizumab-mediated hemostatic function assessed by thrombin generation assay in an in vitro model of factor VIII-depleted thrombophilia plasma.
Int J Hematol
; 119(2): 109-118, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38112996
9.
The protective effect of anti-VEGF-A/Ang-2 bispecific antibody on retinal vein occlusion model mice.
Eur J Pharmacol
; 976: 176691, 2024 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38821166
10.
A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state.
J Thromb Haemost
; 22(2): 430-440, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37940048
11.
Detailed analysis of anti-emicizumab antibody decreasing drug efficacy, using plasma samples from a patient with hemophilia A.
J Thromb Haemost
; 19(12): 2938-2946, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34418287
12.
A modified thrombin generation assay to evaluate the plasma coagulation potential in the presence of emicizumab, the bispecific antibody to factors IXa/X.
Int J Hematol
; 112(5): 621-630, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32748217
13.
Protein S down-regulates factor Xase activity independent of activated protein C: specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa.
Br J Haematol
; 143(3): 409-20, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18759761
14.
Characterization of Anti-Emicizumab Antibodies Using Repository Samples Obtained in Clinical Studies of Emicizumab Conducted in Japan.
TH Open
; 7(3): e241-e243, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37645671
15.
Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro.
TH Open
; 2(1): e96-e103, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31249933
16.
Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens.
Thromb Haemost
; 117(7): 1348-1357, 2017 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28451690
17.
Non-antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity.
MAbs
; 7(1): 120-8, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25524207
18.
The factor VIII heavy chain improves emicizumab-tenase assembly to enhance the factor VIII-mimicking cofactor activity.
Thromb Res
; 166: 77-79, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29684725
19.
Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity.
PLoS One
; 8(2): e57479, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23468998
20.
A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model.
Nat Med
; 18(10): 1570-4, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23023498