Detalhe da pesquisa
1.
Enter Sofosbuvir: The Path to Curing HCV.
Cell
; 167(1): 25-29, 2016 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27634323
2.
Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synthesis.
J Virol
; 96(24): e0115022, 2022 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36448800
3.
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506.
Bioorg Med Chem Lett
; 94: 129456, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37633618
4.
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA.
J Virol
; 95(18): e0057421, 2021 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34191584
5.
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
J Infect Dis
; 224(Supplement_1): S1-S21, 2021 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34111271
6.
Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555628
7.
Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.
Antimicrob Agents Chemother
; 58(11): 6861-9, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25182647
8.
Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161.
Viruses
; 16(3)2024 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38543689
9.
Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer.
J Med Chem
; 67(2): 1421-1446, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38190324
10.
Discovery of C-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2.
ACS Infect Dis
; 10(5): 1780-1792, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38651692
11.
Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J Virol
; 86(12): 6503-11, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22496223
12.
Metabolic activation of the anti-hepatitis C virus nucleotide prodrug PSI-352938.
Antimicrob Agents Chemother
; 56(7): 3767-75, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22526308
13.
Rapid differentiation of nucleotide phosphoramidate diastereomers by electrospray ionization tandem mass spectrometry.
Rapid Commun Mass Spectrom
; 26(16): 1887-92, 2012 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22777791
14.
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.
Bioorg Med Chem Lett
; 22(8): 2938-42, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22425564
15.
ß-D-2'-α-F-2'-ß-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.
Bioorg Med Chem Lett
; 22(18): 5924-9, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22892115
16.
A liquid chromatography-tandem mass spectrometry method for the quantitative determination of diastereomers of a phosphoramidate nucleotide prodrug (PSI-7851) in human plasma.
Biomed Chromatogr
; 26(5): 583-8, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21842514
17.
Introduction to the antibiotic and antiviral compounds themed collection.
RSC Med Chem
; 13(9): 1007, 2022 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36324494
18.
The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly.
RSC Med Chem
; 13(3): 343-349, 2022 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35434625
19.
Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB-506 from Phase 1 studies in healthy subjects and those with hepatitis B.
Hepatol Commun
; 6(12): 3457-3472, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36194181
20.
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein.
Antiviral Res
; 197: 105211, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34826506