Influence of bovine somatotropin on the liver experimentally damaged with carbon tetrachloride.

The influence of bovine somatotropin in acute CCl4 poisoning was studied in rabbits. Somatotropin was injected subcutaneously in doses of 2.5 mg/kg. Liver damage was assessed on the basis of alanine and aspartate aminotransferase and aldolase activities. STH injected during 10 experimental days or 5 days preceding experimental poisoning with CCl4 did not increase the degree of liver damage in comparison with the group of animals injected only with carbon tetrachloride.

[Diagnosis of blood flow disorders in the common carotid arteries by the ultrasonic Doppler method]. / Rozpoznawanie zaburzen przeplywu krwi w tetnicach szyjnych wspólnych metoda ultradzwiekowa oparta na zjawisku Dopplera.

The aim of this work was evaluation of the usefulness of the Doppler ultrasound method for detection of blood flow disturbances in carotid arteries. The investigations were done in 110 patients with symptoms of cerebral circulatory disorders. In 45 patients carotid arteriography was done. In 30 cases arterial reconstructive operations were performed. The curves of blood flow velocity in the common carotid arteries were recorded with a UDP-10 ultrasound blood flow detector. The obtained curves were subjected to morphological analysis and the mean momentary velocity of the systolic and diastolic flow wave was calculated. In 80% of cases with impaired patency of the carotid arteries demonstrated by angiography abnormal curves of blood flow velocity in the common carotid arteries were obtained. The method of ultrasound recording of blood flow velocity is non-invasive and safe and it is very useful for establishing indications to angiography and for postoperative control.

[Left ventricular diastolic function evaluated by Doppler echocardiography in coronary artery disease in relation to to systolic function]. / Czynnosc rozkurczowa lewej komory oceniana metoda echokardiografii dopplerowskiej w chorobie niedokrwiennej serca w zaleznosci od czynnosci skurczowej.

The aim of the study was to assess the relationship between left ventricular (LV) diastolic dysfunction measured by Doppler mitral flow indices (D.m.f.i.) and LV systolic performance in coronary artery disease (CAD). 107 pts with confirmed CAD without or after MI in I, II NYHA class was divided into 2 groups according to ejection fraction (EF) value = 55%. 13 D.m.f.i. regarding to the time, velocity, flow volume and derivates were calculated. In the patient with CAD with normal EF, the diastolic dysfunction was characterised by the impaired relaxation. There were prolonged isovolumic relaxation time IVRT and deceleration time of early filling flow DT, reduced early filling fraction EFF and increased the atrial filling fraction AFF, decreased E/A ratio and E/A-VTI. The regression analysis revealed the positive correlation between EF and DT r = 0.35 and inverse correlation between wall motion score index WMSI and DT r = DT r = -0.33. The stepwise regression analysis revealed that EF and WMSI are independent factors influencing on DT. Our results confirm that diastolic dysfunction precedes the systolic dysfunction in CAD. The correlation between D.m.f.i. and LV systolic function parameters were obtained. The results suggest that the LV systolic function should be take to account in the Doppler mitral flow analysis.