Detalhe da pesquisa
1.
Synthesis and discovery of Baylis-Hillman adducts as potent and selective thioredoxin reductase inhibitors for cancer treatment.
Bioorg Med Chem
; 79: 117169, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36657375
2.
Progress and perspective on hydrogen sulfide donors and their biomedical applications.
Med Res Rev
; 42(5): 1930-1977, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35657029
3.
Small molecules regulating reactive oxygen species homeostasis for cancer therapy.
Med Res Rev
; 41(1): 342-394, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32981100
4.
Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study.
Bioorg Med Chem
; 35: 116073, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33610010
5.
Generation of potent Nrf2 activators via tuning the electrophilicity and steric hindrance of vinyl sulfones for neuroprotection.
Bioorg Chem
; 107: 104520, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33323273
6.
Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition.
Bioorg Chem
; 110: 104814, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33756234
7.
Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety.
Mol Divers
; 25(1): 205-221, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32056130
8.
Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties.
Bioorg Med Chem Lett
; 27(17): 3959-3962, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28789891
9.
Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives.
Bioorg Med Chem Lett
; 27(20): 4694-4697, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28927790
10.
Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction.
Bioorg Med Chem Lett
; 25(13): 2690-3, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25987370
11.
Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents.
Bioorg Med Chem Lett
; 24(16): 3850-3, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25008456
12.
Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents.
Bioorg Med Chem
; 22(22): 6453-8, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25438769
13.
Structural Modification of Aminophenylarsenoxides Generates Candidates for Leukemia Treatment via Thioredoxin Reductase Inhibition.
J Med Chem
; 64(21): 16132-16146, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704769
14.
Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes.
J Agric Food Chem
; 68(7): 2214-2231, 2020 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31986030
15.
Sanguinarine as a new chemical entity of thioredoxin reductase inhibitor to elicit oxidative stress and promote tumor cell apoptosis.
Free Radic Biol Med
; 152: 659-667, 2020 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31931095
16.
Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents.
Nat Prod Res
; 34(14): 2022-2029, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30784310
17.
Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin.
Eur J Med Chem
; 187: 111971, 2020 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31881457
18.
Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives.
Eur J Med Chem
; 115: 109-20, 2016 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26994847