Detalhe da pesquisa
1.
New trends in synthetic drugs and natural products targeting 20S proteasomes in cancers.
Bioorg Chem
; 133: 106427, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36841046
2.
Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone-based derivatives as DHFR inhibitors.
Drug Dev Res
; 84(5): 888-906, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37052308
3.
Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity.
Bioorg Chem
; 118: 105487, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34798455
4.
Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity.
J Enzyme Inhib Med Chem
; 37(1): 2644-2659, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36146940
5.
Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells.
Bioorg Chem
; 107: 104630, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33476864
6.
Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
J Am Chem Soc
; 142(1): 530-544, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31790244
7.
Synthesis of a Pseudodisaccharide Suitable for Synthesis of Ring I Modified 4,5-2-Deoxystreptamine Type Aminoglycoside Antibiotics.
J Org Chem
; 85(11): 7583-7587, 2020 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32336094
8.
Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity.
Bioorg Chem
; 105: 104446, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33171405
9.
Novel sulfonamide derivatives as multitarget antidiabetic agents: design, synthesis, and biological evaluation.
RSC Adv
; 14(11): 7664-7675, 2024 Feb 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38440282
10.
Novel sofosbuvir derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective.
Sci Rep
; 13(1): 23080, 2023 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38155165
11.
Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics.
ChemMedChem
; 17(13): e202200120, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385605
12.
Novel adenosine derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective.
Pharmacol Rep
; 73(6): 1754-1764, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34165771
13.
An Advanced Apralog with Increased inâ vitro and inâ vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.
ChemMedChem
; 16(2): 335-339, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007139
14.
Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4'-derivatives.
Medchemcomm
; 10(6): 946-950, 2019 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31303992
15.
Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics.
ACS Infect Dis
; 4(7): 1114-1120, 2018 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29708331
16.
Selective Protection of Secondary Amines as the N-Phenyltriazenes. Application to Aminoglycoside Antibiotics.
Org Lett
; 17(16): 4006-9, 2015 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26294060