Detalhe da pesquisa
1.
Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.
FEBS Lett
; 520(1-3): 161-6, 2002 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12044890
2.
Separation of bisdioxopiperazine- and vanadate resistance in topoisomerase II.
Biochem Biophys Res Commun
; 334(3): 853-60, 2005 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16053917
3.
Stability of the topoisomerase II closed clamp conformation may influence DNA-stimulated ATP hydrolysis.
J Biol Chem
; 280(12): 11920-9, 2005 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15647268
4.
Probing the role of linker substituents in bisdioxopiperazine analogs for activity against wild-type and mutant human topoisomerase II alpha.
Mol Pharmacol
; 63(5): 1159-68, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12695544