Detalhe da pesquisa
1.
Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications.
Bioorg Med Chem Lett
; 92: 129405, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37414346
2.
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg Med Chem
; 27(3): 457-469, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30606676
3.
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-ß-dependent mechanisms.
Proc Natl Acad Sci U S A
; 113(31): E4558-66, 2016 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27432991
4.
GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein.
Antimicrob Agents Chemother
; 59(11): 7109-12, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26324264
5.
Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy.
Sci Transl Med
; 14(652): eabl5654, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35857625
6.
Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
Bioorg Med Chem
; 17(4): 1739-46, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19179082
7.
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.
J Med Chem
; 61(21): 9473-9499, 2018 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30074795
8.
The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
Structure
; 11(9): 1123-31, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12962630
9.
Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.
J Med Chem
; 58(4): 1630-43, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25574686
10.
Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay.
Bioorg Med Chem Lett
; 17(17): 4987-90, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17562361
11.
Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles.
Bioorg Med Chem Lett
; 16(15): 4036-40, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16714109
12.
Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.
Bioorg Med Chem Lett
; 16(13): 3434-9, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16644215
13.
Identification of metabolites of the tryptase inhibitor CRA-9249: observation of a metabolite derived from an unexpected hydroxylation pathway.
Bioorg Med Chem Lett
; 16(15): 4053-8, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16713261
14.
Structure-guided design of peptide-based tryptase inhibitors.
Biochemistry
; 45(19): 5964-73, 2006 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16681368
15.
Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors.
Bioorg Med Chem Lett
; 16(15): 4085-9, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16725321
16.
Discovery and structure-activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers.
Bioorg Med Chem Lett
; 16(17): 4554-8, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16784854
17.
Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease.
Bioorg Med Chem Lett
; 12(21): 3129-33, 2002 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12372517