Detalhe da pesquisa
1.
1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties.
Bioorg Med Chem Lett
; 47: 128111, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34353608
2.
Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.
Mol Cancer Ther
; 20(12): 2446-2456, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34625502
3.
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Mol Cancer Ther
; 20(1): 26-36, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33037136
4.
Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors.
Org Lett
; 22(16): 6257-6261, 2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32806219
5.
Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
J Med Chem
; 63(11): 5879-5955, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32470302
6.
Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J Med Chem
; 61(8): 3516-3540, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29526098
7.
The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
Structure
; 11(9): 1123-31, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12962630
8.
Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.
J Mol Biol
; 329(1): 93-120, 2003 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-12742021
9.
Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J Mol Biol
; 344(2): 527-47, 2004 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15522303
10.
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.
J Med Chem
; 46(10): 1831-44, 2003 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12723947
11.
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol Cancer Ther
; 8(12): 3181-90, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19934279
12.
Small molecule inhibitors of plasma kallikrein.
Bioorg Med Chem Lett
; 16(7): 2034-6, 2006 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16413183
13.
Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles.
Bioorg Med Chem Lett
; 16(15): 4036-40, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16714109
14.
Discovery of novel hydroxy pyrazole based factor IXa inhibitor.
Bioorg Med Chem Lett
; 16(10): 2796-9, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16487703
15.
Discovery of novel heterocyclic factor VIIa inhibitors.
Bioorg Med Chem Lett
; 16(8): 2270-3, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16460932
16.
Efforts toward oral bioavailability in factor VIIa inhibitors.
Bioorg Med Chem Lett
; 16(14): 3829-32, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16650987
17.
Factor VIIa inhibitors: improved pharmacokinetic parameters.
Bioorg Med Chem Lett
; 16(8): 2243-6, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16455251
18.
Factor VIIa inhibitors: gaining selectivity within the trypsin family.
Bioorg Med Chem Lett
; 16(6): 1596-600, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16413783
19.
Potent 4-amino-5-azaindole factor VIIa inhibitors.
Bioorg Med Chem Lett
; 16(17): 4567-70, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16793264
20.
Structure-guided design of peptide-based tryptase inhibitors.
Biochemistry
; 45(19): 5964-73, 2006 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16681368