Detalhe da pesquisa
1.
Evaluation of Acebilustat, a Selective Inhibitor of Leukotriene B4 Biosynthesis, for Treatment of Outpatients With Mild-Moderate Coronavirus Disease 2019: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial.
Clin Infect Dis
; 77(2): 186-193, 2023 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36996150
2.
Distinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease.
Exp Dermatol
; 29(12): 1191-1198, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33047366
3.
Antiangiogenic and antitumor activity of LP-261, a novel oral tubulin binding agent, alone and in combination with bevacizumab.
Invest New Drugs
; 30(1): 90-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20820910
4.
Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD).
Bioorg Med Chem Lett
; 21(23): 7155-65, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22014550
5.
The COVID-19 Outpatient Pragmatic Platform Study (COPPS): Study design of a multi-center pragmatic platform trial.
Contemp Clin Trials
; 108: 106509, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34274494
6.
Empire-CF study: A phase 2 clinical trial of leukotriene A4 hydrolase inhibitor acebilustat in adult subjects with cystic fibrosis.
J Cyst Fibros
; 20(6): 1026-1034, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34538755
7.
Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases.
Biochemistry
; 49(17): 3611-8, 2010 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20337484
8.
Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1.
Bioorg Med Chem Lett
; 20(22): 6592-6, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20888224
9.
Structure-based design of substituted biphenyl ethylene ethers as ligands binding in the hydrophobic pocket of gp41 and blocking the helical bundle formation.
Bioorg Med Chem Lett
; 19(19): 5693-7, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19699090
10.
EMPIRE-CF: A phase II randomized placebo-controlled trial of once-daily, oral acebilustat in adult patients with cystic fibrosis - Study design and patient demographics.
Contemp Clin Trials
; 72: 86-94, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30056216
11.
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.
J Med Chem
; 48(24): 7520-34, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16302794
12.
Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent.
J Med Chem
; 54(1): 179-200, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21126027
13.
Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state.
Biochemistry
; 46(19): 5687-96, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17441692
14.
Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes.
Bioorg Med Chem Lett
; 15(23): 5274-9, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16169718
15.
Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J Biol Chem
; 280(49): 41077-89, 2005 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16199530
16.
A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinase.
Anal Biochem
; 325(1): 126-36, 2004 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14715293
17.
Improved expression, purification, and crystallization of p38alpha MAP kinase.
Protein Expr Purif
; 37(1): 154-61, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294293
18.
Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains.
Bioorg Med Chem Lett
; 12(8): 1233-5, 2002 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11934595