Detalhe da pesquisa
1.
Selective Uptake of Macromolecules to the Brain in Microfluidics and Animal Models Using the HAVN1 Peptide as a Blood-Brain Barrier Modulator.
Mol Pharm
; 21(4): 1639-1652, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38395041
2.
Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Anal Chem
; 95(49): 17957-17961, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38084380
3.
Metal Ion Interactions with mAbs: Part 2. Zinc-Mediated Aggregation of IgG1 Monoclonal Antibodies.
Pharm Res
; 38(8): 1387-1395, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34382142
4.
A Comprehensive Assessment of All-Oleate Polysorbate 80: Free Fatty Acid Particle Formation, Interfacial Protection and Oxidative Degradation.
Pharm Res
; 38(3): 531-548, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33713012
5.
Protein Stability and Photostability under In Vitro Vitreal Conditions - Implications for Long Acting Delivery of Protein Therapeutics for Ocular Disease.
Pharm Res
; 37(5): 85, 2020 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32337641
6.
Trehalose Limits Fragment Antibody Aggregation and Influences Charge Variant Formation in Spray-Dried Formulations at Elevated Temperatures.
Mol Pharm
; 16(1): 349-358, 2019 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30525659
7.
Photodisruption of the Structurally Conserved Cys-Cys-Trp Triads Leads to Reduction-Resistant Scrambled Intrachain Disulfides in an IgG1 Monoclonal Antibody.
Mol Pharm
; 15(4): 1598-1606, 2018 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29502420
8.
Fragmentation of a Monoclonal Antibody by Peroxotungstate.
Pharm Res
; 35(11): 219, 2018 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30255209
9.
Identification of D-Amino Acids in Light Exposed mAb Formulations.
Pharm Res
; 35(11): 238, 2018 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30334107
10.
Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products.
Pharm Res
; 34(1): 229-242, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27800571
11.
Mechanistic Insights into Radical-Mediated Oxidation of Tryptophan from ab Initio Quantum Chemistry Calculations and QM/MM Molecular Dynamics Simulations.
J Phys Chem A
; 120(18): 2926-39, 2016 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27082439
12.
Screening methods to identify indole derivatives that protect against reactive oxygen species induced tryptophan oxidation in proteins.
Mol Pharm
; 11(4): 1259-72, 2014 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24588659
13.
Reactions of benzene and 3-methylpyrrole with the â¢OH and â¢OOH radicals: an assessment of contemporary density functional theory methods.
J Phys Chem A
; 118(14): 2667-82, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24646154
14.
Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway.
Mol Pharm
; 10(1): 278-88, 2013 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23136850
15.
Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody.
Pharm Res
; 29(1): 187-97, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21809161
16.
Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species.
MAbs
; 14(1): 2122957, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36151884
17.
End-to-End Approach to Surfactant Selection, Risk Mitigation, and Control Strategies for Protein-Based Therapeutics.
AAPS J
; 25(1): 6, 2022 12 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36471030
18.
Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms.
MAbs
; 14(1): 2135183, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36284469
19.
Stress Factors in Protein Drug Product Manufacturing and Their Impact on Product Quality.
J Pharm Sci
; 111(4): 868-886, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34563537
20.
Stress Factors in Primary Packaging, Transportation and Handling of Protein Drug Products and Their Impact on Product Quality.
J Pharm Sci
; 111(4): 887-902, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35081407