Pesquisa | Portal de Pesquisa da BVS

1.

Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells.

Wilmore, Sarah; Rogers-Broadway, Karly-Rai; Taylor, Joe; Lemm, Elizabeth; Fell, Rachel; Stevenson, Freda K; Forconi, Francesco; Steele, Andrew J; Coldwell, Mark; Packham, Graham; Yeomans, Alison.

Cell Mol Life Sci ; 78(17-18): 6337-6349, 2021 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-34398253

2.

Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome Dysregulation.

Johnston, Harvey E; Carter, Matthew J; Larrayoz, Marta; Clarke, James; Garbis, Spiro D; Oscier, David; Strefford, Jonathan C; Steele, Andrew J; Walewska, Renata; Cragg, Mark S.

Mol Cell Proteomics ; 17(4): 776-791, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29367434

3.

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.

Brace, Patience T; Tezera, Liku B; Bielecka, Magdalena K; Mellows, Toby; Garay, Diana; Tian, Shuye; Rand, Lucinda; Green, Justin; Jogai, Sanjay; Steele, Andrew J; Millar, Timothy M; Sanchez-Elsner, Tilman; Friedland, Jon S; Proud, Christopher G; Elkington, Paul T.

PLoS Pathog ; 13(6): e1006367, 2017 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-28570642

4.

Phagocytosing with TP53 and extracellular vesicles.

Steele, Andrew J.

Blood ; 139(25): 3565-3566, 2022 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-35737407

5.

IL-4 enhances expression and function of surface IgM in CLL cells.

Aguilar-Hernandez, Maria M; Blunt, Matthew D; Dobson, Rachel; Yeomans, Alison; Thirdborough, Stephen; Larrayoz, Marta; Smith, Lindsay D; Linley, Adam; Strefford, Jonathan C; Davies, Andrew; Johnson, Peter M W; Savelyeva, Natalia; Cragg, Mark S; Forconi, Francesco; Packham, Graham; Stevenson, Freda K; Steele, Andrew J.

Blood ; 127(24): 3015-25, 2016 06 16.

Artigo em Inglês | MEDLINE | ID: mdl-27002119

6.

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

D'Avola, Annalisa; Drennan, Samantha; Tracy, Ian; Henderson, Isla; Chiecchio, Laura; Larrayoz, Marta; Rose-Zerilli, Matthew; Strefford, Jonathan; Plass, Christoph; Johnson, Peter W; Steele, Andrew J; Packham, Graham; Stevenson, Freda K; Oakes, Christopher C; Forconi, Francesco.

Blood ; 128(6): 816-26, 2016 08 11.

Artigo em Inglês | MEDLINE | ID: mdl-27301861

7.

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

Yeomans, Alison; Thirdborough, Stephen M; Valle-Argos, Beatriz; Linley, Adam; Krysov, Sergey; Hidalgo, Marina Sanchez; Leonard, Elodie; Ishfaq, Muhammad; Wagner, Simon D; Willis, Anne E; Steele, Andrew J; Stevenson, Freda K; Forconi, Francesco; Coldwell, Mark J; Packham, Graham.

Blood ; 127(4): 449-57, 2016 Jan 28.

Artigo em Inglês | MEDLINE | ID: mdl-26491071

8.

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model.

Blunt, Matthew D; Carter, Matthew J; Larrayoz, Marta; Smith, Lindsay D; Aguilar-Hernandez, Maria; Cox, Kerry L; Tipton, Thomas; Reynolds, Mark; Murphy, Sarah; Lemm, Elizabeth; Dias, Samantha; Duncombe, Andrew; Strefford, Jonathan C; Johnson, Peter W M; Forconi, Francesco; Stevenson, Freda K; Packham, Graham; Cragg, Mark S; Steele, Andrew J.

Blood ; 125(26): 4032-41, 2015 Jun 25.

Artigo em Inglês | MEDLINE | ID: mdl-25957390

9.

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.

Krysov, Sergey; Steele, Andrew J; Coelho, Vania; Linley, Adam; Sanchez Hidalgo, Marina; Carter, Matthew; Potter, Kathleen N; Kennedy, Benjamin; Duncombe, Andrew S; Ashton-Key, Margaret; Forconi, Francesco; Stevenson, Freda K; Packham, Graham.

Blood ; 124(20): 3101-9, 2014 Nov 13.

Artigo em Inglês | MEDLINE | ID: mdl-25170122

10.

Rewiring of sIgM-Mediated Intracellular Signaling through the CD180 Toll-like Receptor.

Porakishvili, Nino; Vispute, Ketki; Steele, Andrew J; Rajakaruna, Nadeeka; Kulikova, Nina; Tsertsvadze, Tamar; Nathwani, Amit; Damle, Rajendra N; Clark, Edward A; Rai, Kanti R; Chiorazzi, Nicholas; Lydyard, Peter M.

Mol Med ; 21(1): 46-57, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25611435

11.

Roring ahead with DOCK2.

Steele, Andrew J.

Blood ; 132(2): 115-116, 2018 07 12.

Artigo em Inglês | MEDLINE | ID: mdl-30002044

12.

The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy.

Packham, Graham; Krysov, Serge; Allen, Alex; Savelyeva, Natalia; Steele, Andrew J; Forconi, Francesco; Stevenson, Freda K.

Haematologica ; 99(7): 1138-48, 2014 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-24986876

13.

ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.

Rose-Zerilli, Matthew J J; Forster, Jade; Parker, Helen; Parker, Anton; Rodríguez, Ana E; Chaplin, Tracy; Gardiner, Anne; Steele, Andrew J; Collins, Andrew; Young, Bryan D; Skowronska, Anna; Catovsky, Daniel; Stankovic, Tatjana; Oscier, David G; Strefford, Jonathan C.

Haematologica ; 99(4): 736-42, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24584352

14.

Releasing the brakes on BTK-targeting miRNA.

Blunt, Matthew D; Steele, Andrew J.

Blood ; 128(26): 3023-3024, 2016 12 29.

Artigo em Inglês | MEDLINE | ID: mdl-28034867

15.

To BH3 profile or not to BH3 profile.

Blunt, Matthew D; Steele, Andrew J.

Blood ; 127(25): 3111-2, 2016 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-27340250

16.

B-cell receptor signaling in chronic lymphocytic leukemia.

Stevenson, Freda K; Krysov, Sergey; Davies, Andrew J; Steele, Andrew J; Packham, Graham.

Blood ; 118(16): 4313-20, 2011 Oct 20.

Artigo em Inglês | MEDLINE | ID: mdl-21816833

17.

Clinical impact of ibrutinib plus R-CHOP in untreated DLBCL coexpressing BCL2 and MYC in the phase 3 PHOENIX trial.

Johnson, Peter W M; Balasubramanian, Sriram; Hodkinson, Brendan; Shreeve, S Martin; Sun, Steven; Srinivasan, Srimathi; Steele, Andrew J; Vermeulen, Jessica; Sehn, Laurie H; Wilson, Wyndham H.

Blood Adv ; 7(10): 2008-2017, 2023 05 23.

Artigo em Inglês | MEDLINE | ID: mdl-36696540

18.

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL.

Bryant, Dean; Smith, Lindsay; Rogers-Broadway, Karly Rai; Karydis, Laura; Woo, Jeongmin; Blunt, Matthew D; Forconi, Francesco; Stevenson, Freda K; Goodnow, Christopher; Russell, Amanda; Humburg, Peter; Packham, Graham; Steele, Andrew J; Strefford, Jonathan C.

Leukemia ; 37(7): 1454-1463, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37169950

19.

The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment.

Steele, Andrew J; Prentice, Archibald G; Cwynarski, Kate; Hoffbrand, A Victor; Hart, Stephen M; Lowdell, Mark W; Samuel, Edward R; Wickremasinghe, R Gitendra.

Blood ; 116(22): 4569-77, 2010 Nov 25.

Artigo em Inglês | MEDLINE | ID: mdl-20716767

20.

Dimensionality selection in a molecule-based magnet.

Goddard, Paul A; Manson, Jamie L; Singleton, John; Franke, Isabel; Lancaster, Tom; Steele, Andrew J; Blundell, Stephen J; Baines, Christopher; Pratt, Francis L; McDonald, Ross D; Ayala-Valenzuela, Oscar E; Corbey, Jordan F; Southerland, Heather I; Sengupta, Pinaki; Schlueter, John A.

Phys Rev Lett ; 108(7): 077208, 2012 Feb 17.

Artigo em Inglês | MEDLINE | ID: mdl-22401252

Portal de Pesquisa da BVS

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: