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1.
AJR Am J Roentgenol ; 221(1): 137-138, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-36722760

RESUMO

Ageism is an increasingly recognized form of cognitive bias involving stereotypes, prejudice, and discrimination directed toward people on the basis of their age. Age-based bias influences how medicine is practiced and can result in profoundly negative but avoidable health outcomes. Awareness and education regarding ageism and its manifestations can improve the ability to identify and mitigate ageism. As this Viewpoint describes, radiologists are well situated to be part of the solution in addressing ageism.


Assuntos
Etarismo , Humanos , Etarismo/psicologia , Estereotipagem , Envelhecimento/psicologia , Viés , Inquéritos e Questionários
2.
Semin Musculoskelet Radiol ; 22(4): 386-397, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30134463

RESUMO

Anterior cruciate ligament (ACL) tears are common injuries that if left untreated can result in chronic instability, cartilage damage, meniscal tears, and ligamentous injuries, eventually leading to early osteoarthritis. ACL reconstruction surgeries are therefore increasingly being performed. Despite the fact that most patients achieve excellent postoperative results, patients can present with recurrent instability and pain. These patients often undergo imaging with radiographs, magnetic resonance imaging, and/or computed tomography. An understanding of the imaging appearance of the normal ACL reconstruction and common causes of failure is therefore essential for the interpreting radiologist. This article reviews surgical techniques for ACL reconstruction, highlighting recent technical advances, the normal imaging appearance after ACL reconstruction, etiologies for reconstruction failure, and the diagnosis of these with the aid of imaging.


Assuntos
Lesões do Ligamento Cruzado Anterior/diagnóstico por imagem , Lesões do Ligamento Cruzado Anterior/cirurgia , Reconstrução do Ligamento Cruzado Anterior , Complicações Pós-Operatórias/diagnóstico por imagem , Cartilagem Articular/diagnóstico por imagem , Cartilagem Articular/lesões , Cartilagem Articular/cirurgia , Humanos , Período Pós-Operatório
3.
Skeletal Radiol ; 47(12): 1709-1715, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29785451

RESUMO

We present an uncommon imaging feature with fluid fat tracking within the tendon sheath of the flexor hallucis longus (FHL) after traumatic injury to the ankle joint. We propose a coined medical term "lipidus migrans" to define the presence of floating fat in a tendon sheath. This is due to lipohemarthrosis from intra-articular fracture of the ankle with leakage of fluid fat into the tendon sheath. Communication between the FHL tendon sheath and ankle joint can occur in up to 25% of patients. Radiologists should be aware of the presence of lipidus migrans as a potential posttraumatic complication after intra-articular ankle fracture and that fat in the tendon sheath may mimic fracture fragments or even a tendon sheath tumor.


Assuntos
Tecido Adiposo/diagnóstico por imagem , Traumatismos do Tornozelo/diagnóstico por imagem , Traumatismos dos Tendões/diagnóstico por imagem , Fraturas da Tíbia/diagnóstico por imagem , Acidentes por Quedas , Traumatismos do Tornozelo/cirurgia , Artroscopia , Desbridamento , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Medição da Dor , Fraturas da Coluna Vertebral/diagnóstico por imagem , Traumatismos dos Tendões/cirurgia , Fraturas da Tíbia/cirurgia , Tomografia Computadorizada por Raios X
4.
Eur Radiol ; 27(6): 2497-2506, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27704199

RESUMO

OBJECTIVES: To evaluate the ability of different MRI sequences to detect chondrocalcinosis within knee cartilage and menisci, and to analyze the association with joint degeneration. METHODS: Subjects with radiographic knee chondrocalcinosis (n = 90, age 67.7 ± 7.3 years, 50 women) were selected from the Osteoarthritis Initiative and matched to controls without radiographic chondrocalcinosis (n = 90). Visualization of calcium-containing crystals (CaC) was compared between 3D T1-weighted gradient-echo (T1GE), 3D dual echo steady-state (DESS), 2D intermediate-weighted (IW), and proton density (PD)-weighted fast spin-echo (FSE) sequences obtained with 3T MRI and correlated with a semiquantitative CaC score obtained from radiographs. Structural abnormalities were assessed using Whole-Organ MRI Score (WORMS) and logistic regression models were used to compare cartilage compartments with and without CaC. RESULTS: Correlations between CaC counts of MRI sequences and degree of radiographic calcifications were highest for GE (rT1GE = 0.73, P < 0.001; rDESS = 0.68, P < 0.001) compared to other sequences (P > 0.05). Meniscus WORMS was significantly higher in subjects with chondrocalcinosis compared to controls (P = 0.005). Cartilage defects were significantly more frequent in compartments with CaC than without (patella: P = 0.006; lateral tibia: P < 0.001; lateral femur condyle: P = 0.017). CONCLUSIONS: Gradient-echo sequences were most useful for the detection of chondrocalcinosis and presence of CaC was associated with higher prevalence of cartilage and meniscal damage. KEY POINTS: • Magnetic resonance imaging is useful for assessing burden of calcium-containing crystals (CaC). • Gradient-echo sequences are superior to fast spin echo sequences for CaC imaging. • Presence of CaC is associated with meniscus and cartilage degradation.


Assuntos
Doenças das Cartilagens/diagnóstico , Condrocalcinose/complicações , Condrocalcinose/diagnóstico , Osteoartrite do Joelho/complicações , Idoso , Doenças das Cartilagens/complicações , Doenças das Cartilagens/diagnóstico por imagem , Condrocalcinose/diagnóstico por imagem , Feminino , Humanos , Articulação do Joelho , Estudos Longitudinais , Imageamento por Ressonância Magnética/métodos , Masculino , Menisco/diagnóstico por imagem , Variações Dependentes do Observador , Osteoartrite do Joelho/diagnóstico por imagem , Patela/diagnóstico por imagem , Radiografia
5.
J Comput Assist Tomogr ; 41(1): 1-7, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28081050

RESUMO

This is the third of a series of 4 white papers that represent Expert Consensus Documents developed by the Society of Computed Body Tomography and Magnetic Resonance through its Task Force on dual-energy computed tomography. This paper, part 3, describes computed tomography angiography and thoracic, cardiac, vascular, and musculoskeletal clinical applications. At the end of the discussion of each application category (vascular, cardiac, pulmonary, and musculoskeletal), we present our consensus opinions on the current clinical utility of the application and opportunities for further research.


Assuntos
Doenças Cardiovasculares/diagnóstico por imagem , Pneumopatias/diagnóstico por imagem , Doenças Musculoesqueléticas/diagnóstico por imagem , Guias de Prática Clínica como Assunto , Imagem Radiográfica a Partir de Emissão de Duplo Fóton/normas , Tomografia Computadorizada por Raios X/normas , Medicina Baseada em Evidências , Humanos , Estados Unidos
6.
Skeletal Radiol ; 46(8): 1113-1115, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28405725

RESUMO

OBJECTIVE: To report a novel technique for tibiotalar joint injection that utilizes a posterolateral approach, including indications and technical considerations. METHODS: The posterolateral approach for tibiotalar injection is similar to that used in posterior subtalar joint injections. Using this technique, the tibiotalar joint space is accessed by directing the needle anterosuperiorly beneath the fibula until the posterior aspect of the talar dome has been reached. A retrospective review was conducted of all posterolateral approach tibiotalar joint injections at our institution. RESULTS: Eight patients underwent 12 technically successful therapeutic anesthetic/steroid tibiotalar joint injections using the posterolateral approach under fluoroscopic guidance. All eight patients had anterior predominant arthrosis with large osteophytes and tibiotalar joint space narrowing. The injections were well tolerated without evidence of complications. CONCLUSION: Posterolateral tibiotalar joint injection offers an alternative to the more commonly used anterior approach, particularly in cases of severe anterior predominant arthrosis. An additional advantage of this technique is that the ankle stays in the same position between the initial planning of the needle trajectory and the visualization of contrast flowing into the joint.


Assuntos
Injeções Intra-Articulares/métodos , Articulação Talocalcânea , Idoso , Anestésicos Locais/administração & dosagem , Feminino , Fluoroscopia , Humanos , Masculino , Pessoa de Meia-Idade , Osteófito/diagnóstico por imagem , Osteófito/tratamento farmacológico , Estudos Retrospectivos , Esteroides/administração & dosagem , Articulação Talocalcânea/diagnóstico por imagem , Resultado do Tratamento
7.
Skeletal Radiol ; 46(11): 1507-1512, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28756567

RESUMO

PURPOSE: To assess the MRI features of growth plate injury at the base of the coracoid process. MATERIALS AND METHODS: Subjects were identified through retrospective search of our department imaging database and teaching files and the teaching files of two outside academic institutions. The coracoid base growth plate was examined with attention to widening, irregularity, abnormal signal intensity of the growth plate, and the presence of adjacent soft tissue edema. The apposing coracoid and scapular bony surfaces were examined for signal intensity and morphology. RESULTS: Shoulder MRIs in eight patients with coracoid base growth plate disturbances were retrospectively reviewed (7 males, 1 female, mean age 15 years). Growth plate injury manifested as widening, irregularity and increased signal, apposing bony marrow edema and hypertrophy, and surrounding soft tissue edema. Five subjects were athletes (football, archery, basketball, swimming, rugby), two had a history of neuromuscular disorders, and one subject presented after a fall. Clinical indications included: rule out labral tear (n = 3), rule out rotator cuff tear or fracture after fall (n = 1), nonspecific pain (n = 1), shoulder subluxation, rule out glenoid pathology (n = 1, patient with underlying neuromuscular disorder), muscular dystrophy with shoulder pain (n = 1), and impingement (n = 1). Coracoid growth plate injury was not suspected clinically in any of the patients. CONCLUSION: Awareness of the imaging appearance of coracoid base growth plate injury can aid in a more accurate diagnosis of shoulder MRI studies in young pediatric athletes. While uncommon, coracoid growth plate injury should be considered when assessing children with shoulder symptomatology.


Assuntos
Lâmina de Crescimento/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Fraturas Salter-Harris/diagnóstico por imagem , Lesões do Ombro , Articulação do Ombro/diagnóstico por imagem , Acidentes por Quedas , Adolescente , Traumatismos em Atletas/diagnóstico por imagem , Feminino , Humanos , Masculino , Estudos Retrospectivos
8.
Radiology ; 279(1): 12-28, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26989928

RESUMO

Elbow pain is a frequent presenting symptom in athletes, particularly athletes who throw. The elbow can be injured as a result of acute trauma, such as a direct blow or a fall onto an outstretched hand or from chronic microtrauma. In particular, valgus extension overload during the throwing motion can precipitate a cascade of chronic injuries that can be debilitating for both casual and high-performance athletes. Prompt imaging evaluation facilitates accurate diagnosis and appropriate targeted interventions.


Assuntos
Traumatismos em Atletas/diagnóstico , Diagnóstico por Imagem , Lesões no Cotovelo , Fenômenos Biomecânicos , Humanos , Medição da Dor
9.
Semin Musculoskelet Radiol ; 19(3): 254-68, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26021586

RESUMO

The glenohumeral joint is an inherently unstable articulation and consequently the most frequently subluxed and frankly dislocated joint in the body. Shoulder instability can be uni- or multidirectional related to acute or repetitive stress and is occasionally secondary to congenital or developmental abnormalities such as a lax joint capsule or glenoid dysplasia. The clinical diagnosis of instability can be difficult, and knowledge of the imaging findings of anterior, posterior, multidirectional, and microinstability is essential to guide the correct treatment of these patients. This requires the appropriate use of many different imaging modalities as well as specific positioning and directed protocols. This review article explains the clinical scenarios associated with shoulder instability and how they relate to the choice of imaging techniques. The imaging findings of the most common soft tissue and osseous pathology are reviewed and explained with specific attention to anterior and posterior instability.


Assuntos
Instabilidade Articular/diagnóstico , Imageamento por Ressonância Magnética , Articulação do Ombro , Humanos , Cápsula Articular/lesões , Ligamentos Articulares/lesões , Manguito Rotador/patologia
10.
Skeletal Radiol ; 44(11): 1695-9, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26142538

RESUMO

We present the case of a 46-year-old woman with no significant past medical history who developed left mid-thigh pain and fullness. Imaging demonstrated a mineralized soft-tissue mass, which increased in size during a year of monitoring, but retained a circumscribed appearance. The mass was located in the medial soft tissues of the thigh, separate from the bone on imaging studies, and this finding was confirmed during excision. The mass showed gross and microscopic features of an aneurysmal bone cyst. This diagnosis was supported by cytogenetic analysis revealing a t(17;17)(p13;q21) translocation corresponding to the USP6 and COL1A1 loci. Soft-tissue aneurysmal bone cyst is a rare entity, with fewer than 25 reports in the literature. Limited cytogenetic information about these tumors is available. To our knowledge, the USP6 and COL1A1 rearrangement has only previously been described in a pediatric soft-tissue aneurysmal bone cyst. We also discuss the differential diagnosis of ossifying soft-tissue lesions.


Assuntos
Cistos Ósseos Aneurismáticos/genética , Colágeno Tipo I/genética , Neoplasias de Tecidos Moles/genética , Translocação Genética/genética , Proteases Específicas de Ubiquitina/genética , Cistos Ósseos Aneurismáticos/diagnóstico , Cistos Ósseos Aneurismáticos/cirurgia , Cadeia alfa 1 do Colágeno Tipo I , Diagnóstico Diferencial , Diagnóstico por Imagem , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/cirurgia , Coxa da Perna/cirurgia
11.
Skeletal Radiol ; 44(3): 375-84, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25398362

RESUMO

OBJECTIVES: The purpose of our study was (1) to analyze the flap tear location, direction of displacement and size on magnetic resonance (MR) imaging, (2) to describe associated knee abnormalities including presence of effusion, synovitis, bone marrow edema pattern or ligamentous tear, and (3) to assess clinical findings found with flap tears, including the pain score, and determine differences between operative and nonoperative groups. MATERIALS AND METHODS: A retrospective radiology database search over the last 3 years identified 238 patients with flap tears, of which ultimately 58 with isolated flap tears were included after exclusion of patients with other significant knee internal derangement, severe degenerative change or prior surgery. MR studies of the knee were analyzed by two radiologists. Imaging characteristics were correlated with associated knee abnormalities and clinical findings. Statistical analysis employed linear and logistic regression models. Inter- and intrareader reliability was calculated. RESULTS: The medial meniscus was the most common site of flap tears (52/60, 87 %), with inferior displacement (47/60, 78 %). The degree of tibial cartilage loss had a positive correlation with the visual analog pain scale (p = 0.03). Patients who underwent arthroscopy were younger than those who did not (p = 0.01) and more likely to have a positive clinical McMurray test (p = 0.01). CONCLUSION: Medially and inferiorly displaced flap tears are the most common tear pattern. Those undergoing arthroscopy are more likely to have positive meniscal signs on clinical examination. A greater degree of cartilage loss involving the tibia on MR imaging was associated with increasing visual analog pain scores.


Assuntos
Fraturas de Cartilagem/diagnóstico , Traumatismos do Joelho/diagnóstico , Imageamento por Ressonância Magnética/métodos , Meniscos Tibiais/patologia , Avaliação de Sintomas/métodos , Lesões do Menisco Tibial , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Ruptura/diagnóstico , Sensibilidade e Especificidade , Adulto Jovem
12.
J Magn Reson Imaging ; 40(6): 1280-97, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24753010

RESUMO

Magnetic resonance imaging (MRI) evaluation of the postoperative shoulder presents technical and diagnostic challenges related to imaging artifacts from hardware and micrometallic shavings, postsurgical scarring, and morphological alterations. Improved visualization of postoperative shoulder anatomy and pathology can be obtained with the use of metal artifact reduction techniques as well as MR arthrography. In this article we review the MR techniques that are designed to address these technical and diagnostic challenges, and we discuss the definitions and indications, normal MRI appearance, and complications of routine surgical procedures for treatment of injuries to the rotator cuff, labral ligamentous complex, and biceps tendon.


Assuntos
Artefatos , Prótese Articular , Imageamento por Ressonância Magnética/métodos , Lesões do Manguito Rotador , Manguito Rotador/patologia , Lesões do Ombro , Articulação do Ombro/patologia , Humanos , Aumento da Imagem/métodos , Metais , Cuidados Pós-Operatórios/métodos , Prognóstico , Reprodutibilidade dos Testes , Manguito Rotador/cirurgia , Sensibilidade e Especificidade , Articulação do Ombro/cirurgia , Resultado do Tratamento
13.
AJR Am J Roentgenol ; 203(3): 501-7, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25148152

RESUMO

OBJECTIVE: The purpose of this article is to review frequently encountered pitfalls as they pertain to normal and variant anatomy of the shoulder, including the rotator cuff and rotator cable, blood vessels, glenoid labrum, and the glenohumeral ligaments. CONCLUSION: MRI is the preferred method for evaluating internal derangement of the shoulder. Radiologists interpreting MR images should have a detailed understanding of pertinent anatomy and knowledge of common and uncommon pitfalls to avoid during image interpretation.


Assuntos
Ligamentos Articulares/anormalidades , Ligamentos Articulares/patologia , Imageamento por Ressonância Magnética/métodos , Articulação do Ombro/anatomia & histologia , Articulação do Ombro/patologia , Tendões/anormalidades , Tendões/patologia , Humanos , Ligamentos Articulares/anatomia & histologia , Valores de Referência , Articulação do Ombro/anormalidades , Tendões/anatomia & histologia
14.
AJR Am J Roentgenol ; 203(3): 508-15, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25148153

RESUMO

OBJECTIVE: The purpose of this article is to review frequently encountered pitfalls as they pertain to the biceps tendon, bursae and cysts around the shoulder, incidental findings, postsurgical findings, and frequently encountered imaging artifacts. CONCLUSION: Imaging pitfalls in and around the shoulder are not limited to normal anatomy and anatomic variants. Radiologists must be cognizant of the vast variability of structures in the shoulder and of the incidental and postsurgical findings and artifacts affecting them.


Assuntos
Artefatos , Cistos Ósseos/patologia , Bolsa Sinovial/patologia , Imageamento por Ressonância Magnética/métodos , Ombro/anormalidades , Ombro/patologia , Tendões/patologia , Bolsa Sinovial/anormalidades , Humanos , Aumento da Imagem/métodos , Achados Incidentais , Cuidados Pós-Operatórios , Tendões/anormalidades
15.
Semin Musculoskelet Radiol ; 18(4): 436-47, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25184398

RESUMO

A variety of fluid and fluid-like containing structures can be seen on routine MR imaging of the shoulder including bursal effusions and cystic lesions often in association with rotator cuff tears and impingement. Given its high soft tissue contrast and multiplanar imaging capabilities, MR imaging is the modality of choice in quantifying size, confirming fluid composition, assessing anatomical relationship to the glenohumeral joint, and determining the presence/absence of accompanying intra-articular abnormalities in association with the bursal and juxta-articular cystic findings.


Assuntos
Bolsa Sinovial/patologia , Cistos/diagnóstico , Artropatias/diagnóstico , Imageamento por Ressonância Magnética/métodos , Articulação do Ombro/patologia , Humanos
16.
Skeletal Radiol ; 43(4): 419-21, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24449399

RESUMO

From June 28th to 29th, 2013, the Argentinian ISS Outreach Program took place in collaboration with the Centro de Diagnóstico Dr. Enrique Rossi in the city of Buenos Aires. A total of 690 participants attended. In the following report, we analyze the actual radiologic situation in this South American country. Outreach programs in a country such as Argentina are extremely valuable, as they provide a great opportunity for physicians that cannot travel overseas an attend international meetings such as RSNA, International Skeletal Society, or ARRS.


Assuntos
Pesquisa Biomédica/organização & administração , Relações Comunidade-Instituição , Internato e Residência/organização & administração , Ortopedia/organização & administração , Radiologia/organização & administração , Sociedades Médicas/organização & administração , Argentina
17.
Radiology ; 267(2): 589-95, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23401583

RESUMO

The Society of Radiologists in Ultrasound convened a panel of specialists from a variety of medical disciplines to reach a consensus about the recommended imaging evaluation of painful shoulders with clinically suspected rotator cuff disease. The panel met in Chicago, Ill, on October 18 and 19, 2011, and created this consensus statement regarding the roles of radiography, ultrasonography (US), computed tomography (CT), CT arthrography, magnetic resonance (MR) imaging, and MR arthrography. The consensus panel consisted of two co-moderators, a facilitator, a statistician and health care economist, and 10 physicians who have specialty expertise in shoulder pain evaluation and/or treatment. Of the 13 physicians on the panel, nine were radiologists who were chosen to represent a broad range of skill sets in diagnostic imaging, different practice types (private and academic), and different geographical regions of the United States. Five of the radiologists routinely performed musculoskeletal US as part of their practice and four did not. There was also one representative from each of the following clinical specialties: rheumatology, physical medicine and rehabilitation, orthopedic surgery, and nonoperative sports medicine. The goal of this conference was to construct several algorithms with which to guide the imaging evaluation of suspected rotator cuff disease in patients with a native rotator cuff, patients with a repaired rotator cuff, and patients who have undergone shoulder replacement. The panel hopes that these recommendations will lead to greater uniformity in rotator cuff imaging and more cost-effective care for patients suspected of having rotator cuff abnormality.


Assuntos
Algoritmos , Diagnóstico por Imagem , Manguito Rotador/patologia , Dor de Ombro/diagnóstico , Humanos , Dor de Ombro/patologia
18.
Eur Radiol ; 23(12): 3422-31, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23832388

RESUMO

OBJECTIVES: To evaluate bone marrow changes on knee magnetic resonance imaging (MRI) in patients with 3- to 6-week-long period of unloading. METHODS: MRI knee examinations were performed in 30 patients (14 men, 16 women; aged 20-53 years) at baseline and 5-10 weeks after immobilisation of the ipsilateral lower extremity; subsets of patients were examined at additional time-points. Ten volunteers (4 men, 6 women; aged 20-50 years) were studied as control cohort at two time-points. Bone marrow signal abnormalities were analysed according to: (1) severity, (2) signal alteration relative to hyaline cartilage, (3) morphology, (4) increased vascularity in the knee joint and (5) T1-signal alteration. Spearman's rank correlation test (SRC) and Kendall's tau (KT) were used to compare individual scores. RESULTS: All 30 patients presented abnormal bone marrow findings after unloading, which reached a peak at 10-25 weeks (P <0.001). These findings decreased within 1 year (P < 0.001). High scores of severity were associated with confluent and patchy patterns of bone marrow (SCR = 0.923, P < 0.001 and KT = 0.877, P <0.001). CONCLUSIONS: Signal abnormalities of the bone marrow related to unloading are consistent findings and most prominent 10-25 weeks following immobilisation when both confluent and patchy hyperintense patterns are present.


Assuntos
Medula Óssea/patologia , Imobilização , Articulação do Joelho/patologia , Transtornos Musculares Atróficos/patologia , Adulto , Fraturas do Tornozelo , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior , Deambulação Precoce , Feminino , Fêmur/irrigação sanguínea , Fêmur/patologia , Seguimentos , Traumatismos do Pé/cirurgia , Humanos , Articulação do Joelho/irrigação sanguínea , Estudos Longitudinais , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Patela/irrigação sanguínea , Patela/patologia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Tíbia/irrigação sanguínea , Tíbia/patologia , Suporte de Carga , Adulto Jovem
19.
Eur J Pediatr ; 172(4): 447-58, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22772880

RESUMO

UNLABELLED: Gaucher disease is an inherited pan-ethnic disorder that commonly begins in childhood and is caused by deficient activity of the lysosomal enzyme glucocerebrosidase. Two major phenotypes are recognized: non-neuropathic (type 1) and neuropathic (types 2 and 3). Symptomatic children are severely affected and manifest growth retardation, delayed puberty, early-onset osteopenia, significant splenomegaly, hepatomegaly, thrombocytopenia, anemia, severe bone pain, acute bone crises, and fractures. Symptomatic children with types 1 or 3 should receive enzyme replacement therapy, which will prevent debilitating and often irreversible disease progression and allow those with non-neuropathic disease to lead normal healthy lives. Children should be monitored every 6 months (physical exam including growth, spleen and liver volume, neurologic exam, hematologic indices) and have one to two yearly skeletal assessments (bone density and imaging, preferably with magnetic resonance, of lumbar vertebrae and lower limbs), with specialized cardiovascular monitoring for some type 3 patients. Response to treatment will determine the frequency of monitoring and optimal dose of enzyme replacement. Treatment of children with type 2 (most severe) neuropathic Gaucher disease is supportive. Pre-symptomatic children, usually with type 1 Gaucher, increasingly are being detected because of affected siblings and screening in high-prevalence communities. In this group, annual examinations (including bone density) are recommended. However, monitoring of asymptomatic children with affected siblings should be guided by the age and severity of manifestations in the first affected sibling. Treatment is necessary only if signs and symptoms develop. CONCLUSION: Early detection and treatment of symptomatic types 1 and 3 Gaucher disease with regular monitoring will optimize outcome. Pre-symptomatic children require regular monitoring. Genetic counseling is important.


Assuntos
Terapia de Reposição de Enzimas/métodos , Doença de Gaucher , beta-Glucosidase/genética , Absorciometria de Fóton , Criança , Pré-Escolar , Protocolos Clínicos , Progressão da Doença , Doença de Gaucher/diagnóstico , Doença de Gaucher/fisiopatologia , Doença de Gaucher/terapia , Aconselhamento Genético , Glucosilceramidase/metabolismo , Humanos , beta-Glucosidase/análise
20.
Skeletal Radiol ; 42(4): 499-510, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23229628

RESUMO

OBJECTIVES: Our goals were to quantify the reduction of the magic angle effect using short-tau inversion recovery (STIR) imaging and to determine the value of adding an axial STIR sequence to the magnetic resonance imaging ankle protocol. MATERIALS AND METHODS: Axial STIR sequences were used to measure normal tendon T1 and to estimate signal loss due to the inversion recovery preparation of our clinical protocol. In addition, 102 ankles were imaged with axial fat-suppressed intermediate-weighted fast spin echo and STIR sequences. Two radiologists analyzed the tendons for signal intensity, size, abnormalities, and magic angle effect. The diagnostic value and image quality of the two sequences were compared. RESULTS: We calculated a 50% reduction of signal intensity in healthy tendons on the STIR sequence at TI = 170 ms compared with TI = 0 ms, explaining the decrease in the magic angle effect. Using the STIR sequence, our study demonstrated significantly lower signal intensity within the tendons, more precise tendon size, and a lower magic angle effect compared with the standard intermediate-weighted FSE sequence (p < 0.001). Diagnostic classification of tendon abnormalities using the STIR sequences showed higher sensitivity (82.35% vs. 75.27%) and better agreement with a reference standard than the intermediate-weighted sequences, and superior image quality (p < 0.01). CONCLUSIONS: Axial STIR sequences reduce magic angle effects and improve visualization of ankle tendon pathology.


Assuntos
Traumatismos do Tornozelo/patologia , Articulação do Tornozelo/patologia , Tornozelo/patologia , Imageamento por Ressonância Magnética/métodos , Tendões/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Estudos Retrospectivos , Sensibilidade e Especificidade , Processamento de Sinais Assistido por Computador , Adulto Jovem
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