Detalhe da pesquisa
1.
A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug Chem
; 33(6): 1210-1221, 2022 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35658441
2.
Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads.
Bioconjug Chem
; 31(8): 1893-1898, 2020 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667786
3.
Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation.
Chemistry
; 25(35): 8208-8213, 2019 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30869180
4.
Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class.
Angew Chem Int Ed Engl
; 57(46): 15243-15247, 2018 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30180286
5.
Neutrophil elastase as a versatile cleavage enzyme for activation of αvß3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment.
Front Pharmacol
; 15: 1358393, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38495100
6.
Selective depletion of tumor-infiltrating regulatory T cells with BAY 3375968, a novel Fc-optimized anti-CCR8 antibody.
Clin Exp Med
; 24(1): 122, 2024 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38856863
7.
Enitociclib, a Selective CDK9 Inhibitor, Induces Complete Regression of MYC+ Lymphoma by Downregulation of RNA Polymerase II Mediated Transcription.
Cancer Res Commun
; 3(11): 2268-2279, 2023 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37882668
8.
Discovery of VIP236, an αvß3-Targeted Small-Molecule-Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors.
Cancers (Basel)
; 15(17)2023 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37686656
9.
A Small Molecule-Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an αVß3 Binder for the Treatment of Multiple Cancer Types.
Cancers (Basel)
; 14(2)2022 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35053556
10.
IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies.
Cancers (Basel)
; 12(11)2020 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33233768
11.
Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models.
Oncotarget
; 9(75): 34103-34121, 2018 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344925
12.
Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer.
Mol Cancer Ther
; 16(5): 893-904, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28292941
13.
Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors.
Cancer Res
; 76(21): 6331-6339, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27543601
14.
Evaluation of human pancreatic RNase as effector molecule in a therapeutic antibody platform.
MAbs
; 6(2): 367-80, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24492302
15.
Anetumab ravtansine: a novel mesothelin-targeting antibody-drug conjugate cures tumors with heterogeneous target expression favored by bystander effect.
Mol Cancer Ther
; 13(6): 1537-48, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24714131
16.
Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.
Bioorg Med Chem Lett
; 17(22): 6151-4, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17910915
17.
Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms.
BJU Int
; 98(6): 1259-63, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16956354
18.
Biphenyls as potent vitronectin receptor antagonists.
Bioorg Med Chem Lett
; 12(2): 205-8, 2002 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-11755355
19.
Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
Bioorg Med Chem Lett
; 13(6): 1071-4, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643914