Detalhe da pesquisa
1.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
2.
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Antimicrob Agents Chemother
; 68(4): e0137323, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38380945
3.
Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent.
Mol Pharm
; 20(12): 6213-6225, 2023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37917742
4.
Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent.
Antimicrob Agents Chemother
; 65(2)2021 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33229429
5.
Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.
Antimicrob Agents Chemother
; 60(12): 7086-7097, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27645238
6.
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.
Antimicrob Agents Chemother
; 60(2): 806-17, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26596942
7.
Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.
PLoS Pathog
; 10(4): e1004071, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24722454
8.
In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate.
Antimicrob Agents Chemother
; 59(10): 5909-16, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26149992
9.
Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Antimicrob Agents Chemother
; 58(4): 1930-42, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24419349
10.
Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.
J Nat Prod
; 77(3): 618-24, 2014 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24495105
11.
9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro.
Bioorg Med Chem
; 21(5): 1199-208, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375089
12.
Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
J Med Chem
; 66(3): 1761-1777, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36652602
13.
Synthesis and anti-human immunodeficiency virus activity of substituted ( o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors.
Antivir Chem Chemother
; 27: 2040206619826265, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30788976
14.
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.
Nat Med
; 25(9): 1377-1384, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31501601
15.
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.
J Med Chem
; 61(21): 9473-9499, 2018 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30074795
16.
Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1.
Eur J Med Chem
; 122: 185-195, 2016 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27371922
17.
Rapid In Vitro Evaluation of Antiretroviral Barrier to Resistance at Therapeutic Drug Levels.
AIDS Res Hum Retroviruses
; 32(12): 1237-1247, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27356854
18.
Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.
Org Lett
; 17(2): 262-5, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25560385
19.
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.
Eur J Med Chem
; 46(9): 3748-54, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21664011
20.
Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification.
Bioorg Med Chem Lett
; 15(6): 1697-700, 2005 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15745824