1.
Chem Biodivers
; 19(11): e202200729, 2022 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36102043
RESUMO
Herein we report the synthesis of novel compounds inspired by the antimicrobial activities of nitroazole and thiazolidin-4-one based compounds reported in the literature. Target compounds were investigated inâ vitro for antitubercular, antibacterial, antifungal, and overt cell toxicity properties. All compounds exhibited potent antitubercular activity. Most compounds exhibited low micromolar activity against S. aureus and C. albicans with no overt cell toxicity against HEK-293 cells nor haemolysis against human red blood cells. Notably, compound 3b exhibited low to sub-micromolar activities against Mtb, MRSA, and C. albicans. 3b showed superior activity (0.25â µg/ml) against MRSA compared to vancomycin (1â µg/ml).