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In modern industries, pipelines play a crucial role, both as an essential element in energy transportation (water, gas and electricity) and also in the distribution of these resources. The large size of piping infrastructures, their age and unpredictable external factors are the main difficulties in monitoring the piping system. In this context, the detection and the localization of leaks are challenging but essential, as leaks lead to substantial economic losses. Current methods have many limitations, involving invasive procedures, working only with short pipes or requiring a system shutdown. This paper presents a non-intrusive method based on acoustic signal processing. Leak detection is performed using matched filters, while localization is performed based on the phase diagram representation method and diagram-based entropy computation. Our continuous monitoring system was used for two months and a full comparison with the video inspection-based technique was conducted. The results indicate that this method has a high accuracy, regardless of the length of the pipe.
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Nowadays, unmanned aerial vehicles/drones are involved in a continuously growing number of security incidents. Therefore, the research interest in drone versus human movement detection and characterization is justified by the fact that such devices represent a potential threat for indoor/office intrusion, while normally, a human presence is allowed after passing several security points. Our paper comparatively characterizes the movement of a drone and a human in an indoor environment. The movement map was obtained using advanced signal processing methods such as wavelet transform and the phase diagram concept, and applied to the signal acquired from UWB sensors.
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Movimento , Processamento de Sinais Assistido por Computador , Humanos , Dispositivos Aéreos não Tripulados , Análise de OndaletasRESUMO
Full-duplex (FD) communication systems allow for increased spectral efficiency but require effective self-interference cancellation (SIC) techniques to enable the proper reception of the signal of interest. The underlying idea of digital SIC is to estimate the self-interference (SI) channel based on the received signal and the known transmitted waveform. This is a challenging task since the SI channel involves, especially for mass-market FD transceivers, many nonlinear distortions produced by the impairments of the analog components from the receiving and transmitting chains. Hence, this paper first analyzes the power of the SI components under practical conditions and focuses on the most significant one, which is proven to be produced by the I/Q mixer imbalance. Then, a widely-linear digital SIC approach is adopted, which simultaneously deals with the direct SI and its image component caused by the I/Q imbalance. Finally, the performances achieved by linear and widely-linear SIC approaches are evaluated and compared using an experimental FD platform relying on software-defined radio technology and GNU Radio. Moreover, the considered experimental framework allows us to set different image rejection ratios for the transmission path I/Q mixer and to study its influence on the SIC capability of the discussed approaches.
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This paper studies the secrecy coding analysis achieved by the self-jamming technique in the presence of an eavesdropper by considering a short-packet Full-Duplex (FD) transmission developed based on iterative blind or semi-blind channel estimation and advanced decoding algorithms. Indeed, the legitimate receiver and eavesdropper can simultaneously receive the intended signal from the transmitter and broadcast a self-jamming or jamming signal to the others. Unlike other conventional techniques without feedback, the blind or semi-blind algorithm applied at the legitimate receiver can simultaneously estimate, firstly, the Self-Interference (SI) channel to cancel the SI component and, secondly, estimate the propagation channel, then decode the intended messages by using 5G Quasi-Cyclic Low-Density Parity Check (QC-LDPC) codes. Taking into account the passive eavesdropper case, the blind channel estimation with a feedback scheme is applied, where the temporary estimation of the intended channel and the decoded message are fed back to improve both the channel estimation and the decoding processes. Only the blind algorithm needs to be implemented in the case of a passive eavesdropper because it achieves sufficient performances and does not require adding pilot symbols as the semi-blind algorithm. In the case of an active eavesdropper, based on its robustness in the low region of the Signal-to-Noise Ratio (SNR), the semi-blind algorithm is considered by trading four pilot symbols and only requiring the feedback for channel estimation processes in order to overcome the increase in noise in the legitimate receiver. The results show that the blind or semi-blind algorithms outperform the conventional algorithm in terms of Mean Square Error (MSE), Bit Error Rate (BER) and security gap (Sg). In addition, it has been shown that the blind or semi-blind algorithms are less sensitive to high SI and self-jamming interference power levels imposed by secured FD transmission than the conventional algorithms without feedback.
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In the last years, the commercial drone/unmanned aerial vehicles market has grown due to their technological performances (provided by the multiple onboard available sensors), low price, and ease of use. Being very attractive for an increasing number of applications, their presence represents a major issue for public or classified areas with a special status, because of the rising number of incidents. Our paper proposes a new approach for the drone movement detection and characterization based on the ultra-wide band (UWB) sensing system and advanced signal processing methods. This approach characterizes the movement of the drone using classical methods such as correlation, envelope detection, time-scale analysis, but also a new method, the recurrence plot analysis. The obtained results are compared in terms of movement map accuracy and required computation time in order to offer a future starting point for the drone intrusion detection.
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Importance: Clinical guidelines recommend that children with pleural empyema be treated with chest tube insertion and intrapleural fibrinolytics. The addition of dornase alfa (DNase) has been reported to improve outcomes in adults but remains unproven in children. Objective: To determine if intrapleural tissue plasminogen activator (tPA) and DNase is more effective than tPA and placebo at reducing hospital length of stay in children with pleural empyema. Design, Setting, and Participants: This multicenter, parallel-group, placebo-controlled, superiority randomized clinical trial included children diagnosed as having pleural empyema requiring drainage aged 6 months to 18 years treated at 6 tertiary Canadian children's hospitals. A total of 379 children were assessed for eligibility; 281 were excluded and 98 were randomized. One child was excluded after randomization for not meeting the inclusion criteria. Data were collected from March 4, 2013, to December 13, 2017. Interventions: Participants underwent chest tube insertion and 3 daily administrations of intrapleural tPA, 4 mg, followed by DNase, 5 mg (intervention group), or 5 mL of normal saline (placebo; control group). Participants, families, clinical staff, and members of the study team were blinded to allocation. Main Outcomes and Measures: The primary outcome was hospital length of stay from chest tube insertion to discharge. Secondary outcomes included time to meeting discharge criteria, time to chest tube removal, mean fever duration, additional pleural drainage procedures, hospital readmissions, and total health care cost. Results: Of the 97 analyzed children with pleural empyema, 52 (54%) were male, and the mean (SD) age was 5.1 (3.6) years. A total of 49 children were randomized to tPA and DNase and 48 were randomized to tPA and placebo. Treatment with tPA and DNase was not associated with decreased hospital length of stay compared with tPA and placebo (mean [SD] length of stay, 9.0 [4.9] vs 9.1 [5.3] days; mean difference, -0.1 days; 95% CI, -2.0 to 2.1; P = .96). Similarly, no significant differences were observed for any of the secondary outcomes. Of the 14 adverse events in the tPA and DNase group, 6 (43%) were serious; of the 21 adverse events in the tPA and placebo group, 8 (38%) were serious. There were no deaths. Conclusions and Relevance: The addition of DNase to intrapleural tPA for children with pleural empyema had no effect on hospital length of stay or other outcomes compared with tPA with placebo. Clinical practice guidelines should continue to support the use of chest tube insertion and intrapleural fibrinolytics alone as first-line treatment for pediatric empyema. Trial Registration: ClinicalTrials.gov identifier: NCT01717742.
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Desoxirribonuclease I/uso terapêutico , Empiema Pleural/tratamento farmacológico , Fibrinolíticos/uso terapêutico , Ativador de Plasminogênio Tecidual/uso terapêutico , Adolescente , Tubos Torácicos , Criança , Pré-Escolar , Desoxirribonuclease I/administração & dosagem , Feminino , Fibrinolíticos/administração & dosagem , Custos de Cuidados de Saúde/estatística & dados numéricos , Humanos , Lactente , Tempo de Internação/estatística & dados numéricos , Masculino , Readmissão do Paciente/estatística & dados numéricos , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/uso terapêutico , Ativador de Plasminogênio Tecidual/administração & dosagemRESUMO
BACKGROUND: The full spectrum of clinical manifestations and outcome, and the potential importance of regional or demographic features or viral triggers in paediatric multiple sclerosis (MS), has yet to be fully characterised. Our aim was to determine some of these characteristics in children with MS. METHODS: 137 children with MS and 96 control participants matched by age and geographical region were recruited in a multinational study. They underwent structured clinical-demographic interviews, review of academic performance, physical examination, disability assessment (MS patients only), and standardised assays for IgG antibodies directed against Epstein-Barr virus, cytomegalovirus, parvovirus B19, varicella zoster virus, and herpes simplex virus. FINDINGS: MS was relapsing-remitting at diagnosis in 136 (99%) children. The first MS attack resembled acute disseminated encephalomyelitis (ADEM) in 22 (16%) of the children, most under 10 years old (mean age 7.4 [SD 4.2] years). Children with ADEM-like presentations were significantly younger than were children with polyfocal (11.2 [4.5] years; p<0.0001) or monofocal (12.0 [3.8] years; p=0.0005) presentations. Permanent physical disability (EDSS>or=4.0) developed within 5 years in 15 (13%) of the 120 children for whom EDSS score was available. 23 (17%) had impaired academic performance, which was associated with increasing disease duration (p=0.02). Over 108 (86%) of the children with MS, irrespective of geographical residence, were seropositive for remote EBV infection, compared with only 61 (64%) of matched controls (p=0.025, adjusted for multiple comparisons). Children with MS did not differ from controls in seroprevalence of the other childhood viruses studied, nor with respect to month of birth, sibling number, sibling rank, or exposure to young siblings. INTERPRETATION: Paediatric MS is a relapsing-remitting disease, with presenting features that vary by age at onset. MS in children might be associated with exposure to EBV, suggesting a possible role for EBV in MS pathobiology.
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Anticorpos Antivirais/sangue , Esclerose Múltipla , Pediatria , Adolescente , Adulto , Análise de Variância , Antígenos Virais/imunologia , Estudos de Casos e Controles , Criança , Demografia , Avaliação da Deficiência , Economia , Feminino , Herpesvirus Humano 4/imunologia , Humanos , Entrevista Psicológica , Masculino , Esclerose Múltipla/epidemiologia , Esclerose Múltipla/fisiopatologia , Esclerose Múltipla/virologia , Observação , Estudos Soroepidemiológicos , Índice de Gravidade de Doença , Simplexvirus/imunologiaRESUMO
BACKGROUND: A randomized controlled trial of adults with empyema recently demonstrated decreased length of stay in hospital in patients treated with intrapleurally administered dornase alfa and fibrinolytics compared to fibrinolytics alone. Whether this treatment strategy is safe and effective in children remains unknown. METHODS/DESIGN: This study protocol is for a superiority, placebo-controlled, parallel-design, multicenter randomized controlled trial. The participants are previously well children admitted to a children's hospital with a diagnosis of empyema requiring chest tube insertion and fibrinolytics administered intrapleurally. Children will be randomized after the treating physician has decided that pleural drainage is required but prior to chest tube insertion. After chest tube insertion, participants in the treatment group will receive intrapleurally administered tissue plasminogen activator (tPA) 4 mg followed by dornase alfa 5 mg. Participants in the placebo group will receive tPA 4 mg followed by normal saline. Study treatments will be administered once daily for 3 days. All participants, parents or caregivers, clinicians, and research personnel will remain blinded. The primary outcome is length of stay from chest tube insertion to discharge from hospital. Secondary outcomes include time to meeting discharge criteria, chest tube duration, fever duration, need for additional procedures, adverse events, hospital readmission, cost of hospitalization, and mortality. DISCUSSION: This multicenter randomized controlled trial will assess the safety, effectiveness, and cost-effectiveness of combined treatment with dornase alfa and fibrinolytics compared to fibrinolytics alone for the treatment of empyema in children. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01717742 . Registered on 8 October 2012.
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Desoxirribonuclease I/administração & dosagem , Empiema Pleural/tratamento farmacológico , Fibrinolíticos/administração & dosagem , Ativador de Plasminogênio Tecidual/administração & dosagem , Adolescente , Fatores Etários , Canadá , Tubos Torácicos , Criança , Pré-Escolar , Protocolos Clínicos , Análise Custo-Benefício , Desoxirribonuclease I/efeitos adversos , Desoxirribonuclease I/economia , Drenagem/instrumentação , Vias de Administração de Medicamentos , Custos de Medicamentos , Quimioterapia Combinada , Empiema Pleural/diagnóstico , Empiema Pleural/economia , Empiema Pleural/fisiopatologia , Feminino , Fibrinolíticos/efeitos adversos , Humanos , Lactente , Tempo de Internação , Masculino , Cavidade Pleural , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/efeitos adversos , Proteínas Recombinantes/economia , Projetos de Pesquisa , Fatores de Tempo , Ativador de Plasminogênio Tecidual/efeitos adversos , Ativador de Plasminogênio Tecidual/economia , Resultado do TratamentoRESUMO
OBJECTIVE: To examine the relationship between serum vitamin D concentrations, dietary intake and body mass index among healthy children living in Calgary, Alberta. METHODS: The present cross-sectional study included healthy children two to 13 years of age who presented to the Alberta Children's Hospital for elective surgery during a 12-month period. Data including the child's weight, height, age, sex, ethnicity, dietary intake, use of vitamin supplements, physical activity and time spent outdoors were collected. Serum concentrations of 25-hydroxyvitamin D (25[OH]D) were measured using commercial immunoradiometric assay kits. RESULTS: Serum 25(OH)D concentrations were available for 1442 of 1862 participants, of whom 862 (59.8%) were boys. The mean (± SD) serum 25(OH)D concentration was 86.1±35.1 nmol/L (range 10 nmol/L to 323 nmol/L). Five hundred thirty-nine (37.4%) participants had insufficient vitamin D status (25[OH]D between 25 nmol/L and lower than 75 nmol/L), and vitamin D deficiency (25[OH]D 25 nmol/L or lower) was present in 29 subjects (2.0%). Children in the older age group (nine to 13 years) were more likely to have suboptimal vitamin D (P<0.001). Other risk factors significantly associated with suboptimal vitamin D status included overweight or obesity, nonwhite ethnicity, winter months, dietary vitamin D intake of less than 200 IU/day and less time spent outdoors. CONCLUSION: A high rate of suboptimal vitamin D concentrations was observed among the participants. Beyond promoting a vitamin D-enriched diet, physicians should also consider the body mass index and other risk factors to determine the optimal vitamin D intake for children living in the area studied.