Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on, and around us.

Digital tools and online presence have become a cornerstone in public engagement and involvement strategy and delivery. We here describe the co-production process behind launching a new multilingual resource for schools in the United Kingdom and beyond, jointly between university scientists, engagement professionals, primary and secondary teachers, and web designers. The 'Superbugs' website aims at raising awareness and increasing the public understanding of the microbial world in, on, and around us-with a focus on infection, hygiene, and antimicrobial resistance-and attracted >19,000 online visitors, >33,500 page views, and > 775,000 Twitter impressions over the past 24 months. Superbugs.online is available in English, Welsh, Irish, and Scottish Gaelic, thus making it accessible to everyone in the United Kingdom and Ireland, regardless of the language in which they receive and deliver their science education. The website is easy to navigate and features background information, quizzes, animations, videos, illustrated stories, interactive timelines, games, and protocols for home experiments. All materials are presented in a non-prescriptive way, aimed at allowing flexibility for the materials to be adapted to the individual needs of teachers and pupils alike. Our study has led to a demonstrable impact on the co-production team and on pupils and teachers as key stakeholders, based on a comprehensive evaluation of the co-production process itself, the impact of the end product, and the creation of lasting relationships with stakeholders and co-producers, for the mutual benefit of everyone involved.

Treating Aging Changes of Facial Anatomical Layers with Hyaluronic Acid Fillers.

The aging process affects every anatomical layer of the face. Improved knowledge of how aging occurs in each anatomical layer of the face has helped evolve the facial rejuvenation strategies with HA fillers. Understanding the age-related changes in the anatomical facial layers, including their time of onset and how the changes occur in the different tissue layers, an injector can provide much more targeted and refined HA filler treatments. As fillers' use has increased, there has been a distinct shift away from procedures lifting the skin and SMAS. We can selectively target the anatomical facial layers with HA fillers for more refined and predictable outcomes. An extensive range of HA filler variants is now available. Each filler type is optimized and designed to be injected into specific tissue planes for the best results. Knowing the predictable aging changes in the different tissue layers of the face is crucial as this guides the optimum filler choice. Working knowledge of the individual characteristics of the numerous HA-based products allows for their effective placement in the correct layer. Familiarity with the correct HA product may also help to minimize the downtime and risk of adverse events.

Natural or synthetic - how global trends in textile usage threaten freshwater environments.

As the global demand for textiles increases, so to do the potential environmental impacts that stem from their production, use and disposal. Freshwater ecosystems are particularly at risk: rivers often act as the primary recipients of waste generated during the production of textiles and are subject to pollutants released during the broader lifecycle of a textile product. Here, we investigate how global technological and societal processes shape the way we produce, use and dispose of textiles, and what this means for the environmental quality and ecological health of freshwaters. We examine two predominant 'natural' and synthetic textiles (wool and Polyethylene terephthalate (PET), respectively), and find that risks to freshwater ecosystems vary throughout the lifecycle of these textiles; and across geographies, in-line with regulatory and economic landscapes. Woollen textiles pose most risk during the Production Phase, while PET textiles pose most risk during the Use and Disposal Phases. Our findings show that: (i) both 'natural' and synthetic textiles present substantial challenges for freshwater environments; and (ii) bespoke solutions are needed in areas of the world where the global division of labour and less stringent environmental regulations have concentrated textile production; but also in regions where high textile consumption combines with unsustainable disposal behaviours. Effective mitigation may combine technological advances with societal changes in market mechanisms, regulations, textile use and disposal.