Detalhe da pesquisa
1.
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Nature
; 513(7516): 110-4, 2014 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043045
2.
Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.
Proc Natl Acad Sci U S A
; 113(5): 1387-92, 2016 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26787889
3.
Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Nature
; 528(7580): 152, 2015 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26580013
4.
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
J Biol Chem
; 289(20): 13717-25, 2014 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24668804
5.
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia.
Blood
; 121(24): 4917-24, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23641016
6.
Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.
Oncologist
; 19(6): 602-7, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24760710
7.
Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response.
Blood
; 120(23): 4649-52, 2012 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23074281
8.
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.
Proc Natl Acad Sci U S A
; 108(46): 18843-8, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21976485
9.
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
Oncologist
; 17(1): 72-9, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22180306
10.
Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.
Clin Cancer Res
; 20(7): 1884-90, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24478380
11.
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.
ACS Med Chem Lett
; 3(10): 850-5, 2012 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900389
12.
Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
Nat Genet
; 43(12): 1262-5, 2011 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22057236
13.
Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules.
Am J Physiol Lung Cell Mol Physiol
; 290(6): L1117-30, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16443646
14.
IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients.
J Immunol
; 175(4): 2630-4, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16081838