Are we ready for a name change for schizophrenia? A survey of multiple stakeholders.

About one in 100 people worldwide are diagnosed with schizophrenia. Many people advocate for a name change for the condition, pointing to the stigma and discrimination associated with the term "schizophrenia", as well as to how the name poorly characterizes features of the illness. The purpose of this project was to collect opinions from a broad, diverse sample of stakeholders about possible name changes for schizophrenia. The project represented a partnership between researchers, clinicians, and those with lived experience with psychosis. The group developed a survey to assess opinions about the need for change in the name schizophrenia as well as potential alternate names. We accumulated 1190 responses from a broad array of community stakeholders, including those with lived experience of mental illness, family members, clinicians, researchers, government officials, and the general public. Findings indicated that the majority of respondents (74.1%) favored a name change for schizophrenia. Most (71.4%) found the name stigmatizing. Of the proposed alternate names, those with the most support included "Altered Perception Syndrome", "Psychosis Spectrum Syndrome", and "Neuro-Emotional Integration Disorder". Survey findings provide strong support for renaming schizophrenia. Most expressed hope that a name change will reduce stigma and discrimination.

Altered 'three-flash' illusion in response to two light pulses in schizophrenia.

BACKGROUND: Disorganization is a core dysfunction in schizophrenia. Coherent thought and behavior rely on the interactive neural responses to temporally discrete external events. Previous studies have demonstrated that a single visual stimulus (event) is abnormally affected by another (as in backward masking), but the integration (or 'synthesis') of temporally discrete events remains largely unexplored in schizophrenia. We examined the perceived interaction of two elementary visual events in schizophrenia patients, using a psychophysical approach. METHODS: Two brief, spatially-coincident foveal light pulses (5 ms) were presented with different inter-stimulus intervals (ISIs). At ISIs around 100 ms, a substantial proportion of the light pulse pairs was paradoxically perceived as three flashes, a known phenomenon in normal subjects. The subjects reported the number of flashes perceived ('one', 'two' or 'three'). RESULTS: Schizophrenia patients (n=28) reported fewer 'three flashes' than normal controls (n=26) at the ISIs where 'three flash' reports were greatest in normal subjects (90 to 110 ms). On the other hand, at longer ISIs (130-310 ms) patients reported 'three flashes' in more trials than did normal subjects. The perception of three flashes in patients was correlated with certain aspects of clinical status, including the positive and general subscales of the PANSS. DISCUSSION: The alteration of the 'three-flash' illusion in schizophrenia suggests that the synthesis of discrete visual events is temporally 'dilated' or distorted, which might contribute to disorganized thought and behavior.

Prolonged temporal interaction for peripheral visual processing in schizophrenia: evidence from a three-flash illusion.

BACKGROUND: Coherent perception of the visual world requires orderly processing of spatially and temporally distributed visual information across the visual field. The organization of this visual information is impaired in schizophrenia. We previously found that visual temporal integration in patients is prolonged, using flashes presented to the central fovea. In this study, we investigated this temporal interaction in both the fovea and fairly far out in the peripheral visual field. METHODS: We used a 'three-flash' illusion paradigm in which two spatially-coincident light pulses (of 1 ms each) are perceived by healthy individuals as one, two or three flashes depending on the time interval between the pulses. In each trial, two light pulses were presented in the fovea or 34° out in the right visual field. The inter-stimulus pulse interval (ISI) ranged from 30 to 310 ms. The task for patients (n=28) and controls (n=26) was to indicate the number of flashes (one, two or three) perceived after each two-pulse presentation. RESULTS: For the controls, the peak of the three-flash illusion was shifted to longer ISIs (150 ms) in the periphery compared to the fovea (110 ms). For the patients, the three-flash illusion was greater and occurred at longer ISIs (270 ms in the periphery and 190 ms at the fovea). CONCLUSION: Compared to the central visual field, the range of temporal interactions in the periphery is prolonged to a greater extent in schizophrenia. This exacerbated temporal expansion in peripheral vision suggests a coarse temporal resolution for visual and cognitive organization in this mental disorder.