RESUMO
BACKGROUND: The optimal treatment of desmoid tumours is controversial. We evaluated desmoid management in Dutch familial adenomatous polyposis (FAP) patients. METHODS: Seventy-eight FAP patients with desmoids were identified from the Dutch Polyposis Registry. Data on desmoid morphology, management, and outcome were analysed retrospectively. Progression-free survival (PFS) rates and final outcome were compared for surgical vs non-surgical treatment, for intra-abdominal and extra-abdominal desmoids separately. Also, pharmacological treatment was evaluated for all desmoids. RESULTS: Median follow-up was 8 years. For intra-abdominal desmoids (n=62), PFS rates at 10 years of follow-up were comparable after surgical and non-surgical treatment (33% and 49%, respectively, P=0.163). None of these desmoids could be removed entirely. Eventually, one fifth died from desmoid disease. Most extra-abdominal and abdominal wall desmoids were treated surgically with a PFS rate of 63% and no deaths from desmoid disease. Comparison between NSAID and anti-estrogen treatment showed comparable outcomes. Four of the 10 patients who received chemotherapy had stabilisation of tumour growth, all after doxorubicin combination therapy. CONCLUSION: For intra-abdominal desmoids, a conservative approach and surgery showed comparable outcomes. For extra-abdominal and abdominal wall desmoids, surgery seemed appropriate. Different pharmacological therapies showed comparable outcomes. If chemotherapy was given for progressively growing intra-abdominal desmoids, most favourable outcomes occurred after combinations including doxorubicin.
Assuntos
Polipose Adenomatosa do Colo/terapia , Antineoplásicos/uso terapêutico , Colectomia , Fibromatose Abdominal/terapia , Fibromatose Agressiva/terapia , Polipose Adenomatosa do Colo/complicações , Adolescente , Adulto , Terapia Combinada , Feminino , Fibromatose Abdominal/complicações , Fibromatose Agressiva/complicações , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Países Baixos , Dosagem Radioterapêutica , Estudos Retrospectivos , Taxa de Sobrevida , Resultado do Tratamento , Adulto JovemRESUMO
BACKGROUND/AIMS: 150 cases of Brunner's gland hamartoma (BGH) have been reported in the literature. BGHs are benign and are thought not to cause bile obstruction. METHODS: In this case report, a 60-year-old male is presented with unexplained obstructive jaundice who was also known for over 17 years with diffuse adenomatous hyperplasia of Brunner's glands in the duodenum. Despite the benign preoperative diagnosis, the choice of treatment was Whipple's procedure due to suspicion of a coexisting malignancy. RESULTS: Pathological analysis of the resection specimen revealed multiple BGHs and an adenocarcinoma of the papilla of Vater (PoV). Molecular pathology using loss of heterogeneity analysis was used to confirm that both were different entities. CONCLUSION: It is likely that previous reports of malignant degeneration of BGHs may actually have been cases involving the coexistence of a PoV adenocarcinoma. Physicians need to be alert when a patient presents with BGH accompanied with obstructive jaundice for simultaneously occurring PoV adenocarcinoma.
Assuntos
Adenocarcinoma/epidemiologia , Ampola Hepatopancreática , Glândulas Duodenais , Neoplasias do Ducto Colédoco/epidemiologia , Duodenopatias/epidemiologia , Hamartoma/epidemiologia , Icterícia Obstrutiva/etiologia , Adenocarcinoma/complicações , Adenocarcinoma/cirurgia , Glândulas Duodenais/patologia , Neoplasias do Ducto Colédoco/complicações , Neoplasias do Ducto Colédoco/cirurgia , Comorbidade , Procedimentos Cirúrgicos do Sistema Digestório , Dilatação Patológica , Duodenopatias/patologia , Duodenopatias/cirurgia , Duodeno/diagnóstico por imagem , Duodeno/patologia , Hamartoma/patologia , Hamartoma/cirurgia , Humanos , Hipertrofia , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Common bile duct stones are still a frequent problem. Although new diagnostic and therapeutic techniques are continually being development, they remain poorly defined. Therefore, we decided to evaluate our standard method of diagnosing and treating common bile duct stones. The aim of the study was to determine the short- and long-term results of this method. METHODS: Between 1985 and 1995, 552 consecutive patients (200 men and 352 women; median age, 69 years) underwent endoscopic retrograde cholangiography (ERC) because of suspected common bile duct stones. If stones were detected, they were treated endoscopically, if possible. The results and complications of this policy were recorded. Patients were followed 1-13 years after undergoing ERC and endoscopic sphincterotomy (ES). Long-term results and complications during this period were also recorded. RESULTS: ERC was attempted in 552 patients and succeeded in 510 patients (92%): ES was attempted in 315 patients and failed in five (98%). Duct clearance was done in 271 patients; in 26 of these patients, symptoms disappeared spontaneously. Ten patients underwent common bile duct exploration. Complications occurred in 46 patients (8.3%). Mortality was 0.4%, hemorrhage occurred in 3.6%, pancreatitis in 1.4%, sepsis and cholangitis also in 1.4%, and the lithotripter basket became impacted in four patients (0.8%), necessitating to common bile duct exploration. During follow-up, 45 patients (8%) returned, 35 with recurrent stones, five with cholangitis, two with stenosis of the papilla of Vater, and one with biliary pancreatitis. In 35 cases, complications were treated endoscopically, common bile duct exploration was performed in five cases, and symptoms disappeared spontaneously in five cases. CONCLUSIONS: ERC is a safe and reliable way of diagnosing common bile duct stones, and ES is a very efficient way of treating them. Morbidity and mortality are low, and the long-term results are very good.
Assuntos
Colangiopancreatografia Retrógrada Endoscópica/métodos , Cálculos Biliares/cirurgia , Esfinterotomia Endoscópica/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Ampola Hepatopancreática/patologia , Ampola Hepatopancreática/cirurgia , Criança , Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos , Colangite/etiologia , Colangite/cirurgia , Doenças do Ducto Colédoco/cirurgia , Constrição Patológica/etiologia , Constrição Patológica/cirurgia , Feminino , Seguimentos , Cálculos Biliares/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Pancreatite/etiologia , Pancreatite/cirurgia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Hemorragia Pós-Operatória/etiologia , Hemorragia Pós-Operatória/cirurgia , Esfinterotomia Endoscópica/efeitos adversos , Falha de Tratamento , Resultado do TratamentoRESUMO
Brunner's gland adenoma is a rare benign tumour of the duodenum. Less than 150 cases have been reported in English literature. We report a 73-year-old woman presenting with upper gastrointestinal obstructive symptoms and melena. Duodenoscopy revealed a large pedunculated tumour in the bulbus duodeni. Endoscopic snare polypectomy was successfully performed. Histological examination revealed a Brunner's gland adenoma. The literature on Brunner's gland adenoma is reviewed.
Assuntos
Adenoma/cirurgia , Glândulas Duodenais , Neoplasias Duodenais/cirurgia , Idoso , Endoscopia , Feminino , HumanosAssuntos
Antiulcerosos/uso terapêutico , Cimetidina/uso terapêutico , Furanos/uso terapêutico , Guanidinas/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Adolescente , Adulto , Idoso , Ensaios Clínicos como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , RanitidinaAssuntos
Gastroscopia , Gastrostomia , Estômago/cirurgia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Gastroscópios , Gastrostomia/instrumentação , Humanos , Masculino , Pessoa de Meia-Idade , Agulhas , Técnicas de Sutura/instrumentaçãoAssuntos
Ampola Hepatopancreática/cirurgia , Colelitíase/cirurgia , Cálculos Biliares/cirurgia , Adolescente , Adulto , Idoso , Colangiopancreatografia Retrógrada Endoscópica , Duodenoscopia , Feminino , Cálculos Biliares/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Estudos ProspectivosAssuntos
Obstrução Intestinal/diagnóstico por imagem , Pseudo-Obstrução Intestinal/diagnóstico por imagem , Adulto , Sulfato de Bário , Doença Crônica , Enema , Motilidade Gastrointestinal , Humanos , Pseudo-Obstrução Intestinal/fisiopatologia , Pseudo-Obstrução Intestinal/terapia , Masculino , RadiografiaRESUMO
Two patients in one hospital room acquired pseudomembranous colitis, one shortly after the other. The DNA restriction patterns of isolates from the patients and of four isolates from the environment were indistinguishable from one another and differed from isolates of other patients. Restriction endonuclease digest analysis appears to be a useful method for studying the epidemiology of Clostridium difficile.
Assuntos
Clostridium/genética , Infecção Hospitalar/microbiologia , DNA Bacteriano/análise , Enterocolite Pseudomembranosa/microbiologia , Infecção Hospitalar/transmissão , Enzimas de Restrição do DNA , Desoxirribonuclease HindIII , Eletroforese em Gel de Poliacrilamida , Enterocolite Pseudomembranosa/transmissão , Feminino , Humanos , Técnicas Imunológicas , Pessoa de Meia-IdadeRESUMO
A case of extreme diffuse adenomatous hyperplasia of Brunner's glands was clinically manifested by melena and anemia. Diagnosis was established by barium studies, endoscopy, ultrasonography, computerized tomography, and histology. The radiologic, clinical, pathologic, and differential diagnostic features are reviewed.